Overall the room is not "luxury", although this may be the owner's aim. This is not luxury. I mainly refer to decor and furniture. Room is small, but we only slept there, so this was not an obstacle.
The room was clean, the same as the bathroom.
Towels should be changed every 2 day, however, on the 3rd day we had to ask, as we still had the same towels.
What was best - was the location! We walked everywhere. Domus Spagna is located in the middle of all historical places. We walked to Fontana di Trevi, Vatican, and Colloseum. Restaurants and shops are meters away.
We are glad we stayed in Domus Spagna because of the amazing location.