With loads of experience finding the lowest prices for explorers around the globe, Expedia is a great place to rent your next car. We have suppliers in Historic Downtown La Crosse to select from, offering everything from small and zippy models to roomy, full-size rides. Why not combine your car with your hotel and flights and save even more? From our vacation packages to our exclusive offers and member prices, Expedia will get you in the driver’s seat for less.