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Dec 19 - Dec 20
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Dec 20 - Dec 21
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Dec 19 - Dec 21
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Dec 26 - Dec 28

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Our top choices for South Main hotels

Individually decorated, individually furnished, desk, laptop workspace
Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
South Main
8.6 out of 10, Excellent, (1000)
"Clean room, helpful staff and good location to hospital."
United States
George
The price is ₩130,680
₩152,896 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Comfort Suites Houston near Medical Center- NRG Stadium
Hypo-allergenic bedding, in-room safe, individually decorated
Quality Inn & Suites NRG Park - Medical Center

Quality Inn & Suites NRG Park - Medical Center

Quality Inn & Suites NRG Park - Medical Center
2.5 star property
South Main
6.6 out of 10, (1002)
"Clean rooms, quiet property. We will be back again. "
United States
Javier
The price is ₩78,184
₩91,475 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Quality Inn & Suites NRG Park - Medical Center
Lobby
Wingate Houston near NRG Park/Medical Center

Wingate Houston near NRG Park/Medical Center

Wingate Houston near NRG Park/Medical Center
3.0 star property
South Main
6.6 out of 10, (989)
"Great staff, excellent service and convenient to the area we were wanting to be. Room was clean and bed was very comfortable."
United States
Roy
The price is ₩101,863
₩119,180 total
includes taxes & fees
Dec 22 - Dec 23
Wingate Houston near NRG Park/Medical Center
Premium bedding, pillowtop beds, in-room safe, individually decorated
Wyndham Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center
3.5 star property
South Main
7.2 out of 10, Good, (1204)
"Love this place. Been staying here for many years. "
United States
Reynaldo
The price is ₩131,389
₩153,725 total
includes taxes & fees
Dec 22 - Dec 23
Wyndham Houston near NRG Park/Medical Center
Exterior
Candlewood Suites Houston Medical Center by IHG

Candlewood Suites Houston Medical Center by IHG

Candlewood Suites Houston Medical Center by IHG
2.5 star property
South Main
7.4 out of 10, Good, (824)
"This is a safe, friendly hotel close to MDA Cancer Center"
United States
Myra
The price is ₩103,340
₩120,908 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Candlewood Suites Houston Medical Center by IHG
Indoor pool, open 6 AM to 11 PM, sun loungers
Hilton Americas-Houston

Hilton Americas-Houston

Hilton Americas-Houston
4.0 star property
10.4 km from South Main
9.4 out of 10, Exceptional, (1599)
"Great hotel. Lively bar, great breakfast, friendly staff, nice room, close to everything. "
United States
Thomas
The price is ₩235,024
₩277,932 total
includes taxes & fees
Dec 26 - Dec 27
Hilton Americas-Houston
Premium bedding, in-room safe, desk, laptop workspace
Hyatt Regency Houston Downtown

Hyatt Regency Houston Downtown

Hyatt Regency Houston Downtown
4.0 star property
Houston Central Business District, 10.5 km from South Main
9.2 out of 10, Wonderful, (1095)
"Great staff and nice room. "
United States
Nikiesha
The price is ₩219,966
₩266,439 total
includes taxes & fees
Dec 21 - Dec 22
Hyatt Regency Houston Downtown
Staircase
The Royal Sonesta Houston Galleria

The Royal Sonesta Houston Galleria

The Royal Sonesta Houston Galleria
4.0 star property
The Galleria, 8.8 km from South Main
8.4 out of 10, Very Good, (1470)
"Wonderful hotel!"
United States
Debbie
The price is ₩164,161
₩192,067 total
includes taxes & fees
Dec 23 - Dec 24
The Royal Sonesta Houston Galleria
Breakfast, lunch, dinner served; Regional cuisine
Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston
4.0 star property
Houston Central Business District, 10.9 km from South Main
8.4 out of 10, Very Good, (3954)
"Rooms were great and the staff was absolutely amazing. "
United States
Elmer
The price is ₩117,308
₩137,250 total
includes taxes & fees
Dec 27 - Dec 28
Club Quarters Hotel Downtown, Houston
Lounge
Hyatt Place Houston Downtown

Hyatt Place Houston Downtown

Hyatt Place Houston Downtown
3.0 star property
Houston Central Business District, 11 km from South Main
9.0 out of 10, Wonderful, (1566)
"Great service, room was relaxing. "
United States
Alice
The price is ₩149,990
₩179,267 total
includes taxes & fees
Dec 21 - Dec 22
Hyatt Place Houston Downtown
Free daily continental breakfast
Platinum Inn & Suites Webster

Platinum Inn & Suites Webster

Platinum Inn & Suites Webster
3.0 star property
30.8 km from South Main
7.8 out of 10, Good, (1003)
"It was a great stay just perfect"
United States
elvin
The price is ₩92,858
₩108,644 total
includes taxes & fees
Dec 22 - Dec 23
Platinum Inn & Suites Webster
Bar (on property)
Embassy Suites Houston Downtown

Embassy Suites Houston Downtown

Embassy Suites Houston Downtown
3.5 star property
10.4 km from South Main
9.2 out of 10, Wonderful, (1001)
"Best stay ever! Great location, easy to get to, and the amenities are outstanding!!!"
United States
Robert
The price is ₩180,372
₩211,036 total
includes taxes & fees
Dec 28 - Dec 29
Embassy Suites Houston Downtown
Restaurant
Tru by Hilton Houston Webster NASA

Tru by Hilton Houston Webster NASA

Tru by Hilton Houston Webster NASA
2.5 star property
30.8 km from South Main
9.0 out of 10, Wonderful, (1002)
"The staff was super nice and the location worked great for us! "
Mexico
Valeria
The price is ₩113,792
₩133,136 total
includes taxes & fees
Jan 8 - Jan 9, 2026
Tru by Hilton Houston Webster NASA
View from property
Magnolia Hotel Houston, A Tribute Portfolio Hotel

Magnolia Hotel Houston, A Tribute Portfolio Hotel

Magnolia Hotel Houston, A Tribute Portfolio Hotel
4.0 star property
Downtown Houston, 11.1 km from South Main
9.2 out of 10, Wonderful, (1342)
"Best place to stay downtown Houston!"
United States
John
The price is ₩154,123
₩184,899 total
includes taxes & fees
Dec 21 - Dec 22
Magnolia Hotel Houston, A Tribute Portfolio Hotel
3 bars/lounges, lobby lounge
Omni Houston Hotel

Omni Houston Hotel

Omni Houston Hotel
4.0 star property
10.6 km from South Main
9.0 out of 10, Wonderful, (1001)
"A great place to stay "
United States
Juan
The price is ₩235,035
₩279,117 total
includes taxes & fees
Dec 21 - Dec 22
Omni Houston Hotel
Interior
Holiday Inn Houston Downtown by IHG

Holiday Inn Houston Downtown by IHG

Holiday Inn Houston Downtown by IHG
3.0 star property
Houston Central Business District, 10 km from South Main
8.6 out of 10, Excellent, (1603)
"Great hotel"
United States
MarTesscia
The price is ₩137,294
₩176,650 total
includes taxes & fees
Dec 22 - Dec 23
Holiday Inn Houston Downtown by IHG
Outdoor pool, open 6:00 AM to 10:00 PM, pool umbrellas, sun loungers
Hyatt Regency Houston/Galleria

Hyatt Regency Houston/Galleria

Hyatt Regency Houston/Galleria
4.0 star property
The Galleria, 8.7 km from South Main
9.0 out of 10, Wonderful, (1181)
"Great property! "
United States
Lynn
The price is ₩155,009
₩226,254 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Hyatt Regency Houston/Galleria
Lobby
Hampton Inn Houston Downtown

Hampton Inn Houston Downtown

Hampton Inn Houston Downtown
2.5 star property
10.8 km from South Main
8.8 out of 10, Excellent, (1006)
"Great fresh breakfast easy access to things around you and great service "
United States
Angel
The price is ₩146,477
₩171,378 total
includes taxes & fees
Dec 29 - Dec 30
Hampton Inn Houston Downtown
Outdoor pool, open 9:00 AM to 10:00 PM, sun loungers
Crowne Plaza Houston Med Ctr-Galleria Area by IHG

Crowne Plaza Houston Med Ctr-Galleria Area by IHG

Crowne Plaza Houston Med Ctr-Galleria Area by IHG
3.5 star property
6.5 km from South Main
7.8 out of 10, Good, (1272)
"Enjoyed my stay at hotel "
United States
Reginald
The price is ₩98,911
₩115,725 total
includes taxes & fees
Dec 23 - Dec 24
Crowne Plaza Houston Med Ctr-Galleria Area by IHG
Suite, 1 Bedroom | In-room safe, desk, blackout drapes, iron/ironing board
Hyatt Place Houston/Galleria

Hyatt Place Houston/Galleria

Hyatt Place Houston/Galleria
3.0 star property
8.7 km from South Main
8.8 out of 10, Excellent, (1281)
"Great location "
United States
Ramon Alejandro Caballero
The price is ₩138,770
₩163,335 total
includes taxes & fees
Dec 26 - Dec 27
Hyatt Place Houston/Galleria
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in South Main

Find the best South Main areas and neighborhoods for the activities you enjoy most.
Discovery Green which includes a city, central business district and a high rise building

Downtown Houston

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

The Galleria

Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.

Texas Medical Center

Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.

Northside

While you're in Northside, take in top sights like The Heights Theater or Greenspoint Mall, and hop on the metro to see more the city at Northline Transit Center/HCC Station or Melbourne/North Lindale Station.

Houston Heights

You'll enjoy the coffeehouses and live music in Houston Heights. You might want to make time for a stop at The Heights Theater or Artcar Museum.

Top South Main Hotel Reviews

Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston

10/10 Excellent
"Value"
scott 1-night trip
Posted 22 hours ago
Club Quarters Hotel Downtown, Houston

Frequently asked questions

What is South Main like?
You'll be sure to have fun visiting Houston's South Main neighborhood. Consider a visit to NRG Park as part of your South Main travel plans.
Where is the best hotel for a stay in South Main?
Based on Expedia customer reviews, Comfort Suites Houston near Medical Center- NRG Stadium is the highest ranked property in South Main. This hotel is a short 10-minute walk from NRG Stadium, and it offers free breakfast and a fitness center. Other top choices in the neighborhood include Candlewood Suites Houston Medical Center by IHG and Quality Inn & Suites NRG Park - Medical Center.
How many hotels will I be able to find in South Main?
If you're searching for places to stay in Houston, Expedia has something to meet your needs with 63 South Main hotels and other accommodations to choose from.
If I need to cancel my hotel reservation in South Main, will I receive a refund?
Yes, the majority of hotel bookings are refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then use the filter option "fully refundable" to get the best options available in South Main.
Where can I learn more about changing or cancelling my trip to South Main?
For more details about changing or cancelling your trip to South Main, head over to our customer service page.
What can I see and do in this Houston neighborhood?
NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, be sure to visit other sights like NRG Stadium or NRG Arena.
How can I get around South Main and the greater Houston area?
Ready to get out and explore the city? Fannin South Station is the closest metro station.