Little Italy, San Diego hotel rooms at the Hyatt Hotels

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Compare rooms and suites by Hyatt Hotels in Little Italy with rates, reviews, and availability. Most hotels are fully refundable.

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Top Little Italy Hotel Reviews

Urban Boutique Hotel

10/10 Excellent

"Very convenient to downtown square, dining, shops, farmer's market, touring pier and maritime museums. Friendly staff and clean room."

The DEXTRO Little Italy, BW Premier Collection

10/10 Excellent

"The staff is ABSOLUTELY AMAZING! I was so nervous to send my sibling alone, but she was treated so well. This is so wonderful to hear! THANK YOU ALL SO VERY MUCH FOR THE KINDNESS AND RESPECT YOU HAVE SHOWN! And I heard the room was spacious, clean, beautiful with an amazing view too:)"