Mesotopos Vacation Rentals

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Check prices for these dates

In two weeks
Nov 27 - Nov 29
In two months
Jan 8 - Jan 10
In three months
Feb 5 - Feb 7
In four months
Mar 5 - Mar 7

Our top choices for Mesotopos vacation rentals

A room with a sliding glass door leading to an outdoor area, a round table with two chairs, a sofa, a small table with a bottle, a mirror, and a wooden desk.

1. Apolithon Premium Houses

Apolithon Premium Houses
Lesvos
10.0 out of 10, Exceptional, (1 review)
"A great spot just a short drive from the village. Quiet, safe, and clean… Best shower I had in my 2 weeks in Greece (not just a handheld)!"
Canada
Aaron
The price is ₩108,013
₩121,286 total
includes taxes & fees
Nov 13 - Nov 14
Apolithon Premium Houses
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Find vacation rentals that suit your style

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Apartments
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Condos
Condos

Top Mesotopos Hotel Reviews

A seaside terrace with a long white table, potted plants, and outdoor seating.
Sappho Hotel

Sappho Hotel

Sappho Hotel
Lesvos

10/10 Excellent

Great stay
United States
Mercy
Reviewed July 25, 2026
Sappho Hotel

Find out more about Mesotopos

Search for Vacation rentals in Mesotopos on Expedia.co.uk! You can easily find your home rentals, villas, Vacation apartments in Mesotopos using one of the methods below:

  • View our selection of featured Vacation rentals in Mesotopos
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  • Enter your travel dates to view the best deals on Vacation rentals in Mesotopos while they last

Look no further and take a look at our great range of rental properties in Mesotopos!

Frequently Asked Questions

Are there vacation rentals in Mesotopos?

Yes, you can find vacation rentals close to popular sights in Mesotopos, or you can choose a secluded option if you're looking for a relaxing stay.

What’s there to see and do in Mesotopos?

While exploring the area, visit family-friendly sights like Natural History Museum of the Lesvos Petrified Forest, or get outside and enjoy nature at Lisvori Hot Springs. Skala Kallonis Beach and Iera Moni Limonos are a couple of places you'll find in the larger area.

What’s a vacation rental in Mesotopos like?

Vacation rentals are privately owned accommodations you can stay in for several days or longer in Mesotopos. Vacation rentals feature amenities such as patios, hot tubs, and fire pits so you'll be comfy for your stay. If you're concerned about a clean environment, a vacation rental can offer a sense of safety away from public hotel elevators and busy reception areas while still allowing you the enjoyment of travel. You'll also get more space in a vacation rental than in a traditional hotel, which is another reason why a vacation rental is an attractive choice for family trips or small group gatherings.