Planning for the weather is an important factor for making your trip to Santa Fe de Antioquia a success, especially when you're splurging. The hottest months are usually August and July with an average temp of 66°F, while the coldest months are December and January with an average of 64°F. The rainiest months in Santa Fe de Antioquia are May, April, October, and November, with each month seeing an average of 16 inches of rainfall.