Default HTG hotel image

Find hotels in Santee, NE from ₩159,891

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
Nov 6 - Nov 8
In two weeks
Nov 13 - Nov 15

Filter by

Property class

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Santee hotels

A spacious kitchen with a large island, modern pendant lights, and a ceiling fan.

1. Lewis and Clark Resort

Lewis and Clark Resort
2.5 star property
Yankton
8.8 out of 10, Excellent, (355 reviews)
"My family and friends have stayed here decades, when paddle fishing. They are always freindly, the rooms and their aminities always work. It's very close to Gavins point and always have plenty of parking for a boat and your vehicles."
United States
TREVOR
The price is ₩151,273
₩159,891 total
includes taxes & fees
Nov 2 - Nov 3
Lewis and Clark Resort
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Santee Hotel Reviews

Lewis and Clark Resort

Lewis and Clark Resort

10/10 Excellent
"My family and friends have stayed here decades, when paddle fishing. They are always freindly, the rooms and their aminities always work. It's very close to Gavins point and always have plenty of parking for a boat and your vehicles."
TREVOR 3-night trip
Posted 10 days ago
Lewis and Clark Resort

More cheap stays in Santee

Lewis and Clark Resort

Lewis and Clark Resort

43496 Shore Drive Yankton SD
The price is ₩151,273 per night from Nov 2 to Nov 3
₩151,273
₩159,891 total
Nov 2 - Nov 3
includes taxes & fees

Frequently asked questions

If I need to cancel my hotel reservation in Santee, will I receive a refund?
Yes! The majority of hotel room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in Santee.
Where can I learn more about changing or cancelling my trip to Santee?
For more information about rescheduling or cancelling your trip to Santee, click here.
What is staying in Santee like?
Those traveling to Santee are sure to enjoy the sights to see and things to do. There are 68 hotels and other accommodations in the surrounding area. Find out more about Santee.
What are the top places to visit in Santee?
A favorite place to visit is Lewis and Clark Lake. You'll also find Niobrara State Park and Lewis and Clark Recreation Area in the area. Check out what more to see and do in Expedia's Santee guide.
What's the weather like in Santee?
The hottest months are usually July and August with an average temp of 72°F, while the coldest months are January and February with an average of 26°F. The snowiest months in Santee are January, December, October, and March, with each month seeing an average of 8 inches of snowfall.

Explore a world of travel with Expedia