The Best Luxury Hotels in Southwest Illinois, IL from ₩83,255 in 2026

One of the northermost cypress swamps in the States, the Cache River State Natural area is home to Cypress trees that are over 1000 years old. This is shot from the hiking trail (no boat), and was just a sampling of the scores of cypress trees all around. #treetrove

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Top Southwest Illinois Hotel Reviews

Drury Plaza Hotel Mt. Vernon

10/10 Excellent

"One of the better hotels I have stayed at! Super clean. Great service! Good food options! Liked the evening and breakfast offerings. Very pet friendly. Safe and secure!"

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Drury Plaza Hotel Mt. Vernon

Drury Inn & Suites St. Louis Fairview Heights

La Quinta Inn & Suites by Wyndham Collinsville - St. Louis

Quality Inn O'Fallon IL - St. Louis

Super 8 by Wyndham Troy IL/St. Louis Area

La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis

Red Lion Inn & Suites Pontoon Beach

Red Roof Inn St Louis - Troy, IL

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Find Luxury Hotels in Southwest Illinois, IL

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Treat yourself

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Check availability on Southwest Illinois Luxury Hotels

Top Southwest Illinois Hotel Reviews

Drury Plaza Hotel Mt. Vernon

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