Lodging Image

Find hotels in Cherokee Seneca, Louisville

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Nov 6 - Nov 8
Next weekend
Nov 13 - Nov 15

Filter by

Property class

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Cherokee Seneca hotels

A Holiday Inn Express hotel with a covered parking area and a well-lit facade.

1. Holiday Inn Express Louisville Airport Expo Center by IHG

Holiday Inn Express Louisville Airport Expo Center by IHG
2.5 star property
4 km from Cherokee Seneca
8.6 out of 10, Excellent, (1,002 reviews)
"Cleanliness, parking and friendly staff"
United States
sostene
The price is ₩111,315
₩130,973 total
includes taxes & fees
Dec 7 - Dec 8
Holiday Inn Express Louisville Airport Expo Center by IHG
A bar area with multiple seating options and a large display of liquor bottles.

2. Derby City Gaming & Hotel - A Churchill Downs Property (Adults Only)

Derby City Gaming & Hotel - A Churchill Downs Property (Adults Only)
4.0 star property
6 km from Cherokee Seneca
9.4 out of 10, Exceptional, (2,613 reviews)
"Great spot for business travel with the option to get good food and watch sports on large screens in the evening."
United States
matthew
The price is ₩150,021
₩176,522 total
includes taxes & fees
Nov 8 - Nov 9
Derby City Gaming & Hotel - A Churchill Downs Property (Adults Only)
A modern dining area with multiple tables and chairs, a kitchen area with stainless steel appliances, and a large window with blue curtains.

3. Wingate by Wyndham Louisville Fair and Expo

Wingate by Wyndham Louisville Fair and Expo
3.0 star property
3.7 km from Cherokee Seneca
8.4 out of 10, Very good, (1,259 reviews)
"We had a wonderful stay!"
United States
Bobi
The price is ₩93,478
₩109,986 total
includes taxes & fees
Nov 26 - Nov 27
Wingate by Wyndham Louisville Fair and Expo
A Hilton Garden Inn hotel with a modern design, multiple floors, and a well-lit entrance.

4. Hilton Garden Inn Louisville Mall of St. Matthews

Hilton Garden Inn Louisville Mall of St. Matthews
3.0 star property
St. Matthews, 5.2 km from Cherokee Seneca
9.0 out of 10, Wonderful, (1,002 reviews)
"Great location, clean and tidy room"
United States
Michael
The price is ₩133,069
₩156,569 total
includes taxes & fees
Nov 22 - Nov 23
Hilton Garden Inn Louisville Mall of St. Matthews
A grand hotel lobby with ornate ceiling designs, a central staircase, and a dining area.

5. The Brown Hotel

The Brown Hotel
4.5 star property
Downtown Louisville, 6.4 km from Cherokee Seneca
9.4 out of 10, Exceptional, (1,457 reviews)
"Beautiful hotel!"
United States
Brianne
The price is ₩139,887
₩164,592 total
includes taxes & fees
Nov 25 - Nov 26
The Brown Hotel
An indoor swimming pool with lounge chairs and umbrellas, surrounded by arched windows and a tiled floor.

6. Hawthorn Suites by Wyndham Louisville East

Hawthorn Suites by Wyndham Louisville East
3.0 star property
St. Matthews, 5.2 km from Cherokee Seneca
8.6 out of 10, Excellent, (1,115 reviews)
"Rooms were excellent and very clean"
United States
Vickie
The price is ₩116,841
₩137,476 total
includes taxes & fees
Nov 8 - Nov 9
Hawthorn Suites by Wyndham Louisville East
A modern interior with large windows offering a city view, a circular light fixture, and leather seating.

7. Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham
4.0 star property
Downtown Louisville, 6.5 km from Cherokee Seneca
9.0 out of 10, Wonderful, (4,457 reviews)
"Great place to stay!!!"
United States
Shun
The price is ₩182,557
₩214,797 total
includes taxes & fees
Nov 15 - Nov 16
Galt House Hotel Trademark Collection by Wyndham
A Courtyard by Marriott hotel with a modern facade, multiple floors, and a well-lit entrance.

8. Courtyard by Marriott Louisville Airport

Courtyard by Marriott Louisville Airport
3.0 star property
7.1 km from Cherokee Seneca
9.2 out of 10, Wonderful, (500 reviews)
"Nice size room. Small, comfortable hotel."
United States
RonNeisha
The price is ₩131,567
₩154,802 total
includes taxes & fees
Nov 21 - Nov 22
Courtyard by Marriott Louisville Airport
A rooftop patio with a fire feature, seating, and a view of the sunset.

9. Crowne Plaza Louisville Airport Expo Ctr by IHG

Crowne Plaza Louisville Airport Expo Ctr by IHG
3.5 star property
Fairgrounds, 7 km from Cherokee Seneca
8.8 out of 10, Excellent, (1,951 reviews)
"Great place to stay recommend it to everyone!!"
United States
Scott
The price is ₩138,138
₩162,532 total
includes taxes & fees
Dec 7 - Dec 8
Crowne Plaza Louisville Airport Expo Ctr by IHG
A reception desk with a wooden panel wall, a circular decorative piece, and a sign indicating 'Marriott Bonvoy'.

10. Fairfield Inn & Suites by Marriott Louisville Airport

Fairfield Inn & Suites by Marriott Louisville Airport
3.0 star property
7.3 km from Cherokee Seneca
8.8 out of 10, Excellent, (833 reviews)
"This hotel is awesome! Super clean, with amazing, delicious hot breakfast, very convenient location. Definitely will be back when I travel to Louisville."
United States
Irina
The price is ₩124,258
₩146,201 total
includes taxes & fees
Nov 30 - Dec 1
Fairfield Inn & Suites by Marriott Louisville Airport
A spacious lobby with a high ceiling, a central chandelier, and seating areas with tables and chairs.

11. Omni Louisville Hotel

Omni Louisville Hotel
4.0 star property
Downtown Louisville, 6.2 km from Cherokee Seneca
9.4 out of 10, Exceptional, (2,218 reviews)
"Nice location"
United States
Brian
The price is ₩176,235
₩207,358 total
includes taxes & fees
Nov 7 - Nov 8
Omni Louisville Hotel
An outdoor terrace with tables and chairs, large windows, and a view of the city skyline at sunset.

12. Tempo By Hilton Louisville Downtown Nulu

Tempo By Hilton Louisville Downtown Nulu
3.5 star property
Phoenix Hill, 4.9 km from Cherokee Seneca
9.4 out of 10, Exceptional, (1,150 reviews)
"Great stay!"
United States
Addison
The price is ₩136,368
₩160,451 total
includes taxes & fees
Nov 26 - Nov 27
Tempo By Hilton Louisville Downtown Nulu
An indoor swimming pool with clear water, surrounded by blue walls and large windows.

13. Hampton Inn & Suites By Hilton Louisville East Oxmoor

Hampton Inn & Suites By Hilton Louisville East Oxmoor
2.5 star property
5.8 km from Cherokee Seneca
9.8 out of 10, Exceptional, (266 reviews)
"Room was very spacious, bathroom had great lighting, bed was extremely comfortable!!"
United States
Richard
The price is ₩159,168
₩187,279 total
includes taxes & fees
Nov 15 - Nov 16
Hampton Inn & Suites By Hilton Louisville East Oxmoor
A spacious lobby with a blue sofa, a wooden coffee table, and a chandelier.

14. Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown
4.0 star property
Downtown Louisville, 6.4 km from Cherokee Seneca
9.0 out of 10, Wonderful, (1,388 reviews)
"Great room, excellent staff, exceptional breakfast, very clean."
United States
Chase
The price is ₩174,859
₩205,738 total
includes taxes & fees
Nov 23 - Nov 24
Embassy Suites Louisville Downtown
A modern lobby with a curved reception desk, seating area with sofas and armchairs, and a central coffee table.

15. Springhill Suites by Marriott Louisville Airport

Springhill Suites by Marriott Louisville Airport
3.0 star property
Fairgrounds, 7.1 km from Cherokee Seneca
8.8 out of 10, Excellent, (1,001 reviews)
"Hotel itself and the Rooms were very clean"
United States
Katina
The price is ₩126,252
₩148,548 total
includes taxes & fees
Nov 22 - Nov 23
Springhill Suites by Marriott Louisville Airport
A hotel corridor with a snack bar, refrigerated display, and a long hallway with a patterned carpet.

16. Hampton Inn Louisville-Airport

Hampton Inn Louisville-Airport
2.5 star property
Fairgrounds, 7.2 km from Cherokee Seneca
8.6 out of 10, Excellent, (1,003 reviews)
"Clean room and breakfast was okay."
United States
Ronald
The price is ₩128,670
₩151,393 total
includes taxes & fees
Nov 19 - Nov 20
Hampton Inn Louisville-Airport
A spacious lobby with a blue sofa, yellow chairs, and a dining area with tables and chairs.

17. Hilton Garden Inn Louisville Airport

Hilton Garden Inn Louisville Airport
3.0 star property
Fairgrounds, 6.9 km from Cherokee Seneca
9.0 out of 10, Wonderful, (1,003 reviews)
"Great location for the football game. Very clean and super friendly staff."
United States
Stacy
The price is ₩146,829
₩172,753 total
includes taxes & fees
Nov 28 - Nov 29
Hilton Garden Inn Louisville Airport
A modern indoor seating area with wooden tables and chairs, large windows offering a view of the outdoors, and a mix of red and beige seating.

18. Tru by Hilton Louisville Airport

Tru by Hilton Louisville Airport
2.5 star property
Fairgrounds, 7.2 km from Cherokee Seneca
9.0 out of 10, Wonderful, (1,002 reviews)
"Great room and good breakfast comfy bed and pillows"
United States
Massimo
The price is ₩131,139
₩154,299 total
includes taxes & fees
Nov 22 - Nov 23
Tru by Hilton Louisville Airport
An outdoor dining area with a long table and wicker chairs, overhead lighting, and a view of the city.

19. Hotel Genevieve part of JdV by Hyatt

Hotel Genevieve part of JdV by Hyatt
4.0 star property
East Market District, 4.9 km from Cherokee Seneca
9.2 out of 10, Wonderful, (1,085 reviews)
"We’ve stayed here a number of times and we love it. Right in the middle of NuLu, it’s the perfect spot."
United States
Jesse
The price is ₩191,919
₩225,811 total
includes taxes & fees
Nov 23 - Nov 24
Hotel Genevieve part of JdV by Hyatt
A spacious lobby with a central escalator, seating areas, and modern lighting.

20. Hyatt Regency Louisville

Hyatt Regency Louisville
4.0 star property
Downtown Louisville, 6.4 km from Cherokee Seneca
8.8 out of 10, Excellent, (1,000 reviews)
"amazing location will definitely be back"
United States
Michael Jered
The price is ₩167,577
₩197,173 total
includes taxes & fees
Nov 23 - Nov 24
Hyatt Regency Louisville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in Cherokee Seneca

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
A bar area with multiple seating options and a large display of liquor bottles.
Derby City Gaming & Hotel - A Churchill Downs Property (Adults Only)
4.0 star property
9.4
Exceptional
2,613 reviews
View
An indoor swimming pool with clear water, surrounded by blue walls and large windows.
Hampton Inn & Suites By Hilton Louisville East Oxmoor
2.5 star property
9.8
Exceptional
266 reviews
View
A grand hotel lobby with ornate ceiling designs, a central staircase, and a dining area.
The Brown Hotel
4.5 star property
9.4
Exceptional
1,457 reviews
View
A Holiday Inn Express hotel with a covered parking area and a well-lit facade.
Holiday Inn Express Louisville Airport Expo Center by IHG
2.5 star property
8.6
Excellent
1,002 reviews
View
A Hilton Garden Inn hotel with a modern design, multiple floors, and a well-lit entrance.
Hilton Garden Inn Louisville Mall of St. Matthews
3.0 star property
9.0
Wonderful
1,002 reviews
View

Where to stay in Cherokee Seneca

Find the best Cherokee Seneca areas and neighborhoods for the activities you enjoy most.
A steamboat docked at a pier with a bridge in the background.

Downtown Louisville

Explore "Museum Row" in the West Main District, catch a game at Louisville Slugger Field, or stroll across the pedestrian-only Big Four Bridge. Enjoy diverse attractions, restaurants, and the Louie Link skywalk.

A nighttime cityscape with a brightly lit bridge and a skyline featuring a prominent dome-shaped building.

St. Matthews

Major shopping destination with the fifth-largest mall in Kentucky, Mall St. Matthews, and smaller centers along Shelbyville Road. Don't miss the historic St. Matthew's Episcopal Church and Holy Trinity.

A historical marker for the Conrad-Caldwell House, detailing its architectural style and history.

Old Louisville

Boasting Victorian architecture and the highest concentration of stained glass windows in residential homes, Old Louisville offers a walkable neighborhood with pedestrian-only streets, diverse dining options, and attractions like Central Park and the Conrad-Caldwell House.

A nighttime hot air balloon festival with colorful balloons, including one labeled "OLIVER WINERY."
Photo by Hyelsinta
Open Photo by Hyelsinta

Fairgrounds

While visiting Fairgrounds, you might make a stop by sights like Freedom Hall and Kentucky Kingdom.

A city skyline at dusk with illuminated buildings reflecting on the water.

Jeffersontown

Jeffersontown is known for its abundant dining options, and you can plan a trip to Jeffersontown Commons Shopping Center and Bluegrass Indoor Karting while you're in town.

Top Cherokee Seneca Hotel Reviews

Derby City Gaming & Hotel - A Churchill Downs Property (Adults Only)

Derby City Gaming & Hotel - A Churchill Downs Property (Adults Only)

10/10 Excellent
"I would make a suggestion that you have a mini fridge for leftover food from eating downstairs or complimentary waters maybe in room. Besides that the room and hotel is lovely!"
Dawn M 1-night trip
Posted 15 hours ago
Derby City Gaming & Hotel - A Churchill Downs Property (Adults Only)

Frequently asked questions

What is Cherokee Seneca like?
You'll be sure to have fun visiting Louisville's Cherokee Seneca neighborhood.
If I need to cancel my hotel reservation in Cherokee Seneca, will I receive a refund?
Yes, you'll find most hotel room reservations are fully refundable provided that you cancel before the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a reservation that's non-refundable, it may still be possible to cancel it and be given a refund within 24 hours of booking. Add your dates and click on "Search", then use the "fully refundable" filter to review top deals in Cherokee Seneca.
Where can I learn more about changing or cancelling my trip to Cherokee Seneca?
To find more details about changing or cancelling your trip to Cherokee Seneca, head over to our customer service page.
What is there to do around this Louisville neighborhood?
Peterson-Dumesnil House, Historic Frankfort Avenue, and Colonel Sanders' Grave are just a few of the places to visit in and around Cherokee Seneca. Norton Fine Arts Center and Muhammad Ali Gravesite are also worth a visit when you're out sightseeing in Louisville.