Find hotels near Highlands Regional Medical Center, Prestonsburg from ₩99,965

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Dec 29 - Dec 30
Tomorrow
Dec 30 - Dec 31
This weekend
Jan 2 - Jan 4
Next weekend
Jan 9 - Jan 11

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Highlands Regional Medical Center hotels

Desk, blackout drapes, iron/ironing board, free cribs/infant beds
Comfort Suites Prestonsburg West

Comfort Suites Prestonsburg West

Comfort Suites Prestonsburg West
2.5 star property
8.4 km from Highlands Regional Medical Center
8.6 out of 10, Excellent, (695)
"Love the pool always warm staff is friendly "
United States
Misty
The price is ₩145,824
₩165,391 total
includes taxes & fees
Dec 31 - Jan 1, 2026
Comfort Suites Prestonsburg West
Lobby
Ramada Hotel & Conference Center by Wyndham Paintsville

Ramada Hotel & Conference Center by Wyndham Paintsville

Ramada Hotel & Conference Center by Wyndham Paintsville
2.5 star property
10.3 km from Highlands Regional Medical Center
8.8 out of 10, Excellent, (549)
"Beautiful hotel, wonderful breakfast and staff, couldnt be happier with our stay"
United States
Sandra
The price is ₩155,627
₩171,562 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Ramada Hotel & Conference Center by Wyndham Paintsville
Exterior
Quality Inn & Suites Prestonsburg next to Mountain Arts Center

Quality Inn & Suites Prestonsburg next to Mountain Arts Center

Quality Inn & Suites Prestonsburg next to Mountain Arts Center
2.5 star property
8.3 km from Highlands Regional Medical Center
8.0 out of 10, Very Good, (359)
"Nice clean place. Great rooms and price. Very friendly staff. "
United States
Jason
The price is ₩150,653
₩170,870 total
includes taxes & fees
Dec 30 - Dec 31
Quality Inn & Suites Prestonsburg next to Mountain Arts Center
Desk, iron/ironing board, cribs/infant beds, rollaway beds
Days Inn by Wyndham Paintsville

Days Inn by Wyndham Paintsville

Days Inn by Wyndham Paintsville
2.0 star property
9.8 km from Highlands Regional Medical Center
7.6 out of 10, Good, (515)
"Had the greatest and most compassionate staff. "
United States
Jaime
The price is ₩98,033
₩108,071 total
includes taxes & fees
Dec 31 - Jan 1, 2026
Days Inn by Wyndham Paintsville
Exterior
Super 8 by Wyndham Prestonsburg

Super 8 by Wyndham Prestonsburg

Super 8 by Wyndham Prestonsburg
2.0 star property
8.3 km from Highlands Regional Medical Center
6.4 out of 10, (519)
"Friendly staff, clean room. "
United States
Heather
The price is ₩90,680
₩99,965 total
includes taxes & fees
Jan 28 - Jan 29, 2026
Super 8 by Wyndham Prestonsburg
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Highlands Regional Medical Center Hotel Reviews

Comfort Inn Pikeville

Comfort Inn Pikeville

10/10 Excellent
"The beds were super comfortable and clean! Friendly staff and an overall enjoyable experience!"
Kenneth 1-night trip
Posted 4 days ago
Comfort Inn Pikeville

Hotels near other Highlands Regional Medical Center attractions

East Kentucky Science Center & Varia Planetarium

You can spend an afternoon studying the exhibits at East Kentucky Science Center & Varia Planetarium during your trip to Prestonsburg. Discover the area's mountain views and sunrises.
See properties

Jenny Wiley State Resort Park

4.1/5 (58 reviews)
Explore the great outdoors at Jenny Wiley State Resort Park, a lovely green space in Prestonsburg. Wander the riverfront or discover the area's mountain views.
See properties

Frequently asked questions

What's the area like around Highlands Regional Medical Center?
Highlands Regional Medical Center is located in Prestonsburg. You'll find 15 hotels and other accommodations within a few miles for a convenient home base.
What's the best hotel to stay near Highlands Regional Medical Center?
Quality Inn & Suites Prestonsburg next to Mountain Arts Center is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and free parking. You'll find it 5.1 mi (8.3 km) from Highlands Regional Medical Center. Other good choices in the area include Comfort Suites Prestonsburg West and Ramada Hotel & Conference Center by Wyndham Paintsville.
How many hotels will I be able to find near Highlands Regional Medical Center?
Expedia has 15 hotels and other accommodations a few miles from Highlands Regional Medical Center.
If I need to cancel the hotel reservation for my stay near Highlands Regional Medical Center, will I receive a refund?
Yes! You'll find that most room reservations are refundable provided that you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of the scheduled arrival. If you booked a non-refundable reservation, you might still have the option to cancel and be given a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then you can filter by "fully refundable" to review the top deals on offer near Highlands Regional Medical Center.
Where can I learn more about changing or cancelling my trip in the area near Highlands Regional Medical Center?
To find more details about changing or cancelling your stay near Highlands Regional Medical Center, click here.
What can I see and do near Highlands Regional Medical Center?
You'll want to browse the exhibits at East Kentucky Science Center & Varia Planetarium and Loretta Lynn's Home. Sights like Loretta Lynn's Birthplace - Butcher Hollow and Samuel May House highlight some of the local culture. You might spend a leisurely day outdoors at Jenny Wiley State Resort Park and Archer Park.