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Oct 21 - Oct 22
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Oct 22 - Oct 23
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Oct 23 - Oct 25
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Our top choices for Lake Issaqueena hotels

A white, two-story house with a front porch, surrounded by trees and shrubs.
A two-story building with a white exterior, a front door, and a balcony.
A hallway with a wooden bench, a chair, a cabinet, and a painting on the wall.
A dining area with round tables, black chairs, and white tablecloths.

1. Liberty Hall Bed and Breakfast

Liberty Hall Bed and Breakfast
13 km from Lake Issaqueena
United States
Christine
₩121,106
₩134,427 total
includes taxes & fees
Nov 4 - Nov 5
Liberty Hall Bed and Breakfast
A spacious hallway with a wooden ceiling, a sofa, a chair, and a lamp.
A brick building with a sign reading "The Inn at Patrick Square".
A hotel with a brick facade, multiple windows, and a sign reading "The Inn at Patrick Square".
A modern restaurant with a marble-top dining table, blue upholstered chairs, and a variety of food items displayed in the background.

2. The Inn at Patrick Square

The Inn at Patrick Square
9.2 km from Lake Issaqueena
United States
Jennifer
₩197,686
₩219,432 total
includes taxes & fees
Oct 27 - Oct 28
The Inn at Patrick Square
A cabin with a cozy interior, a wooden exterior, and a view of the forest.
A wooden interior with a table, chair, and a hanging lantern.
A wooden cabin bedroom with a bed, a desk, and a window overlooking a forest.
Private kitchen

3. Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
15.8 km from Lake Issaqueena
United States
Winston
₩122,924
₩193,594 total
includes taxes & fees
Nov 1 - Nov 2
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
An outdoor patio area with a fire pit, seating, and string lights.
A modern restaurant with a central counter, seating area, and a TV displaying news.
A modern hotel with a prominent 'tru by Hilton' sign, a well-lit entrance, and a parking area.
A modern indoor space with a mix of seating options, including a sofa and tables, under stylish pendant lighting.

4. Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
5.8 km from Lake Issaqueena
United States
Melissa
₩144,138
₩158,552 total
includes taxes & fees
Nov 8 - Nov 9
Tru by Hilton Seneca Clemson
A large, curved swimming pool with lounge chairs and umbrellas, surrounded by landscaped areas and a building in the background.
A golf course with a water body, trees, and a distant view of a bridge.
A modern building with a central entrance, surrounded by a well-maintained lawn and trees.
A golf course with a clubhouse, surrounded by dense trees and a large body of water.

5. Clemson University's James F. Martin Inn

Clemson University's James F. Martin Inn
8.7 km from Lake Issaqueena
United States
Lilllian
₩197,686
₩219,431 total
includes taxes & fees
Oct 26 - Oct 27
Clemson University's James F. Martin Inn
A modern lounge area with a brick accent wall, a fireplace, and comfortable seating.
A bar area with a counter, multiple chairs, and a display of bottles and glasses.
A hotel room with a bed, a sofa, a dining table with chairs, a coffee machine, and a TV mounted on the wall.
A modern living room with a sofa, two armchairs, a coffee table, and a potted plant.

6. The Abernathy of Clemson

The Abernathy of Clemson
6.7 km from Lake Issaqueena
United States
Amy
₩213,739
₩237,250 total
includes taxes & fees
Nov 17 - Nov 18
The Abernathy of Clemson
A multi-level interior with a spiral staircase, wooden railings, and a seating area with tables and chairs.
A spacious living area with a sofa, ottoman, and chairs, a dining area with a table, and a kitchen in the background.
A spacious restaurant with high ceilings, wooden flooring, and a mix of modern and classic furniture.
An outdoor patio with wicker furniture, a round table, and a fountain.

7. The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
6.7 km from Lake Issaqueena
United States
Laurrie
₩277,291
₩307,793 total
includes taxes & fees
Oct 26 - Oct 27
The Shepherd Hotel Downtown Clemson
A Holiday Inn Express hotel with a stone facade, large windows, and a parking lot.
A modern hotel room with a desk, two patterned chairs, a red armchair, a round table, and a large window.
A hotel breakfast area with a self-serve station, including a refrigerator, coffee machine, and fruit display.
A hotel room with a large bed, bedside tables, a desk with a chair, a TV, and a window with a view.

8. Holiday Inn Express & Suites Clemson by IHG

Holiday Inn Express & Suites Clemson by IHG
7.1 km from Lake Issaqueena
United States
John
₩171,151
₩189,978 total
includes taxes & fees
Oct 25 - Oct 26
Holiday Inn Express & Suites Clemson by IHG
A multi-story hotel with a swimming pool, landscaped grounds, and a parking area.
A spacious dining area with a long wooden table and patterned upholstered chairs.
A swimming pool with lounge chairs and a covered patio area, surrounded by trees and a view of a lake.
A spacious lobby with a stone fireplace, modern lighting fixtures, and a seating area with sofas and a coffee table.

9. Lakeside Lodge Clemson

Lakeside Lodge Clemson
5.6 km from Lake Issaqueena
United States
Steven
₩144,616
₩179,523 total
includes taxes & fees
Oct 26 - Oct 27
Lakeside Lodge Clemson
A modern kitchen area with a bar counter and seating.
A modern living room with a grey sofa, purple and orange cushions, a coffee table with magazines, and a large window with patterned curtains.
A Hampton Inn with a modern design, featuring a prominent entrance and outdoor seating area.
A modern bar area with high stools and a poolside view.

10. Hampton Inn Clemson-University Area

Hampton Inn Clemson-University Area
5.5 km from Lake Issaqueena
United States
Blaise
₩145,478
₩161,482 total
includes taxes & fees
Oct 28 - Oct 29
Hampton Inn Clemson-University Area
A bar area with a granite countertop, bar stools, and a menu board.
A modern lobby with a reception desk, a seating area with three chairs, a round table, and a bookshelf with books.
A Courtyard Marriott hotel with a brick facade, multiple floors, and a covered entrance area.
An outdoor patio with a circular fire pit surrounded by wicker furniture and a pergola overhead.

11. Courtyard Marriott Clemson

Courtyard Marriott Clemson
7.3 km from Lake Issaqueena
United States
kim
₩147,535
₩163,764 total
includes taxes & fees
Nov 8 - Nov 9
Courtyard Marriott Clemson
Room
A spacious room with a large window, a flat-screen TV mounted on the wall, and a seating area with sofas and chairs.
A modern kitchen with a microwave, toaster, and coffee maker. There are white bowls and a coffee station.
A hotel reception area with two reception desks, a digital screen, and a tiled floor.

12. Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area
6.6 km from Lake Issaqueena
United States
Sherie
₩139,839
₩155,223 total
includes taxes & fees
Nov 15 - Nov 16
Comfort Inn & Suites Clemson - University Area
A reception area with a reception desk, a sofa, a staircase, and a wall with artwork.
A dining area with a brick floor, wooden tables, and chairs, a kitchen counter with appliances, and large windows offering a view of the outside.
A hotel room with two beds, a desk, a television, and a clock on the wall.
A tiger mascot holding a sign with "HOWARD'S ROCK" text, a staircase, and a desk with a computer.

13. Inn @ Clemson

Inn @ Clemson
6.5 km from Lake Issaqueena
United States
Kristi
₩106,273
₩117,962 total
includes taxes & fees
Oct 25 - Oct 26
Inn @ Clemson
A spacious indoor dining area with multiple tables and chairs, a food service counter, and a modern architectural design with balconies.
A spacious indoor area with multiple levels of balconies, seating areas, and a central open space.
A spacious indoor area with multiple seating arrangements, a ping pong table, and a bar area with purple accents.
A hotel room with a bed, a desk, a TV, a mirror, and a nightstand with a lamp.

14. Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center
6.8 km from Lake Issaqueena
United States
Angela
₩139,839
₩155,223 total
includes taxes & fees
Oct 26 - Oct 27
Best Western Plus Clemson Hotel & Conference Center
A restaurant interior with a counter, seating area, and a TV mounted on the wall.
A multi-story motel with a central entrance, a flag, and a parking lot with several cars.
A hotel room with a TV on a wooden cabinet, a desk with a lamp, a framed picture, and a chair.
A hotel room with a bed, desk, TV, and a bathroom visible through an open door.

15. Quality Inn Seneca US-123

Quality Inn Seneca US-123
13.5 km from Lake Issaqueena
United States
Barry
₩112,243
₩131,810 total
includes taxes & fees
Oct 28 - Oct 29
Quality Inn Seneca US-123
A cozy living room with a fireplace, a dining area with a table and chairs, and a large wooden door.
A room with wooden sliding doors, a small black table with a potted plant, and a circular sign with the words "stay awhile".
Private kitchen
A bedroom with a bed, bedside tables, a nightstand, a wooden floor, a door, and a wall-mounted shelf.

16. Clemson Memorabilia House

Clemson Memorabilia House
9.3 km from Lake Issaqueena
United States
Ashley
₩118,081
₩315,157 total
includes taxes & fees
Nov 4 - Nov 5
Clemson Memorabilia House
A hotel room with a bed, a desk, a chair, a large window with curtains, a bathroom with a bathtub, and a flat-screen TV.
A rectangular swimming pool with a metal ladder, surrounded by lounge chairs and tables, with a wooded area in the background.
A reception area with a brick wall, a reception desk, and a glass door leading outside.
A multi-story hotel with a prominent entrance, parking area, and a car parked in front.

17. Best Western Seneca-Clemson

Best Western Seneca-Clemson
9.7 km from Lake Issaqueena
United States
Michelle
₩124,064
₩136,471 total
includes taxes & fees
Oct 27 - Oct 28
Best Western Seneca-Clemson
A swimming pool with lounge chairs and a covered area with tables and chairs.
A spacious living room with a dark leather sofa, a wooden coffee table, and a dining area with a table and chairs. Large windows provide natural light and views of the outdoors.
A modern kitchen with white cabinets, a stainless steel refrigerator, and a microwave.
A modern bedroom with a large bed, a ceiling fan, and a view of the outdoors through a window.

18. Carolina Camp Cedar

Carolina Camp Cedar
20.2 km from Lake Issaqueena
United States
Katlynn
₩144,616
₩270,976 total
includes taxes & fees
Oct 25 - Oct 26
Carolina Camp Cedar
A dining area with a table and chairs, large windows with a view of the outside, and a green sofa.
A hotel room with two beds, a desk, a chair, a TV, and a painting on the wall.
A gazebo with a tiled roof and wooden pillars, surrounded by a fence and potted plants.
A reception desk with a vase of flowers, framed pictures, and a printer.

19. Days Inn by Wyndham Clemson

Days Inn by Wyndham Clemson
7.1 km from Lake Issaqueena
United States
David
₩106,273
₩117,963 total
includes taxes & fees
Oct 25 - Oct 26
Days Inn by Wyndham Clemson
A hotel dining area with a long table, multiple chairs, and a bar in the background.
A reception area with a counter, chairs, and a patterned rug.
A hotel pantry with shelves stocked with snacks, a microwave, and a refrigerator with beverages.
A Hampton Inn & Suites hotel with a well-lit entrance, a parking lot, and a clear view of the building's exterior.

20. Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
8.6 km from Lake Issaqueena
United States
Sasha
₩163,562
₩179,917 total
includes taxes & fees
Oct 25 - Oct 26
Hampton Inn & Suites Seneca-Clemson Area
View all properties

Compare popular hotels close to Lake Issaqueena

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
A white, two-story house with a front porch, surrounded by trees and shrubs.
Liberty Hall Bed and Breakfast
9.8
Exceptional
104 reviews
View
A spacious hallway with a wooden ceiling, a sofa, a chair, and a lamp.
The Inn at Patrick Square
9.8
Exceptional
931 reviews
View
A cabin with a cozy interior, a wooden exterior, and a view of the forest.
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
9.8
Exceptional
114 reviews
View
An outdoor patio area with a fire pit, seating, and string lights.
Tru by Hilton Seneca Clemson
9.2
Wonderful
900 reviews
View
A large, curved swimming pool with lounge chairs and umbrellas, surrounded by landscaped areas and a building in the background.
Clemson University's James F. Martin Inn
9.4
Exceptional
1,003 reviews
View

Hotels recommended for families near Lake Issaqueena

A multi-story hotel with a swimming pool, landscaped grounds, and a parking area.
A spacious dining area with a long wooden table and patterned upholstered chairs.
A swimming pool with lounge chairs and a covered patio area, surrounded by trees and a view of a lake.
A spacious lobby with a stone fireplace, modern lighting fixtures, and a seating area with sofas and a coffee table.

Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
₩144,616
₩179,523 total
includes taxes & fees
Oct 26 - Oct 27
Lakeside Lodge Clemson
A modern lounge area with a brick accent wall, a fireplace, and comfortable seating.
A bar area with a counter, multiple chairs, and a display of bottles and glasses.
A hotel room with a bed, a sofa, a dining table with chairs, a coffee machine, and a TV mounted on the wall.
A modern living room with a sofa, two armchairs, a coffee table, and a potted plant.

The Abernathy of Clemson

The Abernathy of Clemson
Clemson
₩213,739
₩237,250 total
includes taxes & fees
Nov 17 - Nov 18
The Abernathy of Clemson
A multi-level interior with a spiral staircase, wooden railings, and a seating area with tables and chairs.
A spacious living area with a sofa, ottoman, and chairs, a dining area with a table, and a kitchen in the background.
A spacious restaurant with high ceilings, wooden flooring, and a mix of modern and classic furniture.
An outdoor patio with wicker furniture, a round table, and a fountain.

The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
Clemson
₩277,291
₩307,793 total
includes taxes & fees
Oct 26 - Oct 27
The Shepherd Hotel Downtown Clemson
An outdoor patio area with a fire pit, seating, and string lights.
A modern restaurant with a central counter, seating area, and a TV displaying news.
A modern hotel with a prominent 'tru by Hilton' sign, a well-lit entrance, and a parking area.
A modern indoor space with a mix of seating options, including a sofa and tables, under stylish pendant lighting.

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
Seneca
₩144,138
₩158,552 total
includes taxes & fees
Nov 8 - Nov 9
Tru by Hilton Seneca Clemson
Room
A spacious room with a large window, a flat-screen TV mounted on the wall, and a seating area with sofas and chairs.
A modern kitchen with a microwave, toaster, and coffee maker. There are white bowls and a coffee station.
A hotel reception area with two reception desks, a digital screen, and a tiled floor.

Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area
Clemson
₩139,839
₩155,223 total
includes taxes & fees
Nov 15 - Nov 16
Comfort Inn & Suites Clemson - University Area
A reception area with a reception desk, a sofa, a staircase, and a wall with artwork.
A dining area with a brick floor, wooden tables, and chairs, a kitchen counter with appliances, and large windows offering a view of the outside.
A hotel room with two beds, a desk, a television, and a clock on the wall.
A tiger mascot holding a sign with "HOWARD'S ROCK" text, a staircase, and a desk with a computer.

Inn @ Clemson

Inn @ Clemson
Clemson
₩106,273
₩117,962 total
includes taxes & fees
Oct 25 - Oct 26
Inn @ Clemson
A Holiday Inn Express hotel with a stone facade, large windows, and a parking lot.
A modern hotel room with a desk, two patterned chairs, a red armchair, a round table, and a large window.
A hotel breakfast area with a self-serve station, including a refrigerator, coffee machine, and fruit display.
A hotel room with a large bed, bedside tables, a desk with a chair, a TV, and a window with a view.

Holiday Inn Express & Suites Clemson by IHG

Holiday Inn Express & Suites Clemson by IHG
Clemson
₩171,151
₩189,978 total
includes taxes & fees
Oct 25 - Oct 26
Holiday Inn Express & Suites Clemson by IHG
A spacious indoor dining area with multiple tables and chairs, a food service counter, and a modern architectural design with balconies.
A spacious indoor area with multiple levels of balconies, seating areas, and a central open space.
A spacious indoor area with multiple seating arrangements, a ping pong table, and a bar area with purple accents.
A hotel room with a bed, a desk, a TV, a mirror, and a nightstand with a lamp.

Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center
Clemson
₩139,839
₩155,223 total
includes taxes & fees
Oct 26 - Oct 27
Best Western Plus Clemson Hotel & Conference Center

Top Lake Issaqueena Hotel Reviews

Lakeside Lodge Clemson

Lakeside Lodge Clemson

10/10 Excellent
"Friendly front desk and bar staff. We had a really nice overnight stay."
Sherry 1-night trip
Posted less than an hour ago
Lakeside Lodge Clemson
Clemson University's James F. Martin Inn

Clemson University's James F. Martin Inn

10/10 Excellent
"The room was on the ground level so walked out onto the gorgeous sprawling golf course and the lake and the beautiful pool/hot tub facilites. The location was great for where you meet to start a Clemson tour, however it's completely away from the main part of campus and the town otherwise, so nothing is really walkable from it. That's not a big deal b/c everything is a less than 5-10 min drive and the location is so pretty and peaceful it's worth it. we used the pool and hot tub at 8pm and were the only ones there and it was really lovely. The bed was incredibly hard, which was my only complaint."
Alina 1-night trip
Posted 23 hours ago
Clemson University's James F. Martin Inn
Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area

10/10 Excellent
"Updated room and friendly staff."
Sherie 1-night trip
Posted 3 days ago
Comfort Inn & Suites Clemson - University Area
The Abernathy of Clemson

The Abernathy of Clemson

8/10 Good
"The hotel staff was very nice. The room and property were clean. Right across the street from campus and close to lots of food options. Parking was included. They do not have an onsite gym and did not have a store with necessities such as medicine."
Jennifer 1-night trip
Posted 6 days ago
The Abernathy of Clemson
Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson

10/10 Excellent
"The staff were very friendly and everything was nice and clean! A great selection for breakfast!"
Alexis 2-night trip
Posted 6 days ago
Tru by Hilton Seneca Clemson
Inn @ Clemson

Inn @ Clemson

10/10 Excellent
"Clean room, comfortable beds, good breakfast, great price!"
Kristi 1-night trip
Posted 7 days ago
Inn @ Clemson

Other attractions near Lake Issaqueena

Larry W. Abernathy Waterfront Park

8.6/10 (58 reviews)
Larry W. Abernathy Waterfront Park is just one of the places to see in Clemson, so why not enjoy the other things to explore during your travels? Experience the area's theater scene or attend a football game.
See properties

Littlejohn Coliseum

9.4/10 (141 reviews)
Catch an event at Littlejohn Coliseum during your trip to Clemson. Amble around the area's lakeside or attend a football game.
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Sloan Tennis Center

Catch an event at Sloan Tennis Center during your trip to Clemson. You can attend a football game while in the area.
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Memorial Stadium

9.6/10 (410 reviews)
Catch an event at Memorial Stadium during your trip to Clemson. Experience the area's theater scene or attend a football game.
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Clemson Area African American Museum

You can spend time browsing the exhibits at Clemson Area African American Museum in Clemson. You can attend a football game while in the area.
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Wyndham Plaza

You can browse for the perfect souvenirs at Wyndham Plaza during your visit to Seneca. Stroll along the lakeside or attend a sporting event in this family-friendly area.
See properties

World of Energy

You can spend an afternoon exploring the galleries in World of Energy in Seneca. Amble around this family-friendly area's lakeside or attend a sporting event.
See properties

Frequently asked questions

What's the area like around Lake Issaqueena?
Lake Issaqueena is located in Central. You'll find 209 hotels and other accommodations within a few miles for a convenient home base.
What's the best place to stay near Lake Issaqueena?
Lakeside Lodge Clemson is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and free parking. It's located 3.5 mi (5.6 km) from Lake Issaqueena. Other good choices within a few miles include Best Western Plus Clemson Hotel & Conference Center and Comfort Inn & Suites Clemson - University Area.
How many hotels are there close to Lake Issaqueena?
Expedia has 209 hotels and other accommodations a few miles from Lake Issaqueena.
If I need to cancel the hotel reservation for my stay near Lake Issaqueena, will I receive a refund?
Yes! Most hotel reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If you have a reservation that's non-refundable, you might be able to still cancel and get a refund within 24 hours of booking. Add dates, click "Search", then you can filter by "fully refundable" to review the top deals on offer near Lake Issaqueena.
Where can I learn more about changing or cancelling my trip in the area near Lake Issaqueena?
For more details about updating your stay near Lake Issaqueena or cancelling it, head over to our customer service page.
What can I see and do near Lake Issaqueena?
You'll want to browse the exhibits at Fort Hill and Clemson Area African American Museum. Explore nature at Keowee Reservoir and Larry W. Abernathy Waterfront Park. If you've got some time to explore the area around Lake Issaqueena, you may want to make a stop by Littlejohn Coliseum, Memorial Stadium, and Sloan Tennis Center.