Lodging Image

Find hotels in Main Street Fort Pierce, Fort Pierce

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
Nov 6 - Nov 8
In two weeks
Nov 13 - Nov 15

Filter by

Property class

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Main Street Fort Pierce hotels

A modern hotel lobby with a central seating area, a bar, and a coffee station.

1. Hampton Inn & Suites Ft. Pierce

Hampton Inn & Suites Ft. Pierce
2.5 star property
7.9 km from Main Street Fort Pierce
9.2 out of 10, Wonderful, (1,001 reviews)
"Staff were very nice on all shifts."
United States
Ronald
The price is ₩123,593
₩138,424 total
includes taxes & fees
Nov 15 - Nov 16
Hampton Inn & Suites Ft. Pierce
A modern reception area with a long corridor, a reception desk, and a seating area with tables and chairs.

2. Holiday Inn Express Hotel & Suites Fort Pierce West by IHG

Holiday Inn Express Hotel & Suites Fort Pierce West by IHG
2.5 star property
8.3 km from Main Street Fort Pierce
9.0 out of 10, Wonderful, (907 reviews)
"I would definitely stay at this hotel again"
United States
Rodney
The price is ₩146,271
₩163,824 total
includes taxes & fees
Nov 1 - Nov 2
Holiday Inn Express Hotel & Suites Fort Pierce West by IHG
A hotel lobby with a large reception desk, multiple seating areas, and a patterned carpet.

3. Fairfield Inn & Suites by Marriott Fort Pierce

Fairfield Inn & Suites by Marriott Fort Pierce
3.0 star property
7.7 km from Main Street Fort Pierce
8.8 out of 10, Excellent, (1,003 reviews)
"Plenty of parking and cozy room."
United States
Katherine
The price is ₩123,593
₩138,425 total
includes taxes & fees
Nov 19 - Nov 20
Fairfield Inn & Suites by Marriott Fort Pierce
An outdoor seating area with fire feature, stone walls, and a view into the building.

4. Home2 Suites by Hilton Ft. Pierce I-95

Home2 Suites by Hilton Ft. Pierce I-95
3.0 star property
7.8 km from Main Street Fort Pierce
9.4 out of 10, Exceptional, (277 reviews)
"Nice little breakfast...very clean and easy check in and check out..."
United States
JERRY
The price is ₩164,413
₩184,142 total
includes taxes & fees
Nov 14 - Nov 15
Home2 Suites by Hilton Ft. Pierce I-95
A pool area with lounge chairs and a hot tub, surrounded by palm trees and a view of the ocean.

5. Hutchinson Island Hotel

Hutchinson Island Hotel
2.5 star property
3.1 km from Main Street Fort Pierce
8.2 out of 10, Very good, (1,371 reviews)
"Clean room nice staff and awesome view!! Will be staying there again soon!"
United States
Lana
The price is ₩137,749
₩179,689 total
includes taxes & fees
Nov 1 - Nov 2
Hutchinson Island Hotel
A spacious living area with a grey sofa, a blue sofa, and a wooden accent wall with a flat-screen TV.

6. La Quinta Inn & Suites by Wyndham Ft. Pierce

La Quinta Inn & Suites by Wyndham Ft. Pierce
3.0 star property
7.9 km from Main Street Fort Pierce
8.6 out of 10, Excellent, (1,002 reviews)
"We have booked rooms at this hotel multiple nights in the last few months for our employees that are working on a project in the area. The staff have been great!"
United States
Tyler
The price is ₩117,390
₩131,476 total
includes taxes & fees
Nov 8 - Nov 9
La Quinta Inn & Suites by Wyndham Ft. Pierce
A hotel lobby with a reception desk, seating area, and a hallway leading to other rooms.

7. Days Inn & Suites by Wyndham Fort Pierce I-95

Days Inn & Suites by Wyndham Fort Pierce I-95
2.5 star property
7.8 km from Main Street Fort Pierce
7.4 out of 10, Good, (1,003 reviews)
"The staff was excellent"
United States
Carlton
The price is ₩78,825
₩88,283 total
includes taxes & fees
Nov 8 - Nov 9
Days Inn & Suites by Wyndham Fort Pierce I-95
A hotel entrance with a welcome sign, a black mat, and two potted plants.

8. At Home Inn

At Home Inn
2.5 star property
8.2 km from Main Street Fort Pierce
8.2 out of 10, Very good, (1,361 reviews)
"Everything was great!"
United States
John
The price is ₩81,027
₩90,750 total
includes taxes & fees
Nov 29 - Nov 30
At Home Inn
A hotel room with a bed, a sofa, and a small table. There are framed pictures on the wall.

9. Comfort Suites Fort Pierce I-95

Comfort Suites Fort Pierce I-95
2.5 star property
7.7 km from Main Street Fort Pierce
7.8 out of 10, Good, (979 reviews)
"Clean rooms, friendly staff"
United States
Marina
The price is ₩119,871
₩134,251 total
includes taxes & fees
Nov 29 - Nov 30
Comfort Suites Fort Pierce I-95
A clear blue swimming pool with lounge chairs and umbrellas, surrounded by palm trees and a gazebo.

10. Best Western Port St. Lucie

Best Western Port St. Lucie
2.5 star property
14 km from Main Street Fort Pierce
8.8 out of 10, Excellent, (1,004 reviews)
"Yes good place to stay"
United States
Valery
The price is ₩120,045
₩134,450 total
includes taxes & fees
Nov 15 - Nov 16
Best Western Port St. Lucie
A hotel room with two beds, a television, a ceiling fan, and a view of the beach.

11. The Royal Inn Beach Hotel Hutchinson Island

The Royal Inn Beach Hotel Hutchinson Island
2.5 star property
3.8 km from Main Street Fort Pierce
7.2 out of 10, Good, (1,002 reviews)
"My go-to hotel when I need a place to get away!"
United States
Taylor
The price is ₩126,061
₩162,599 total
includes taxes & fees
Nov 1 - Nov 2
The Royal Inn Beach Hotel Hutchinson Island
A Holiday Inn Express & Suites hotel with a modern design, featuring a prominent entrance, well-maintained landscaping, and a clear view of the sky.

12. Holiday Inn Express & Suites Port St. Lucie West by IHG

Holiday Inn Express & Suites Port St. Lucie West by IHG
2.5 star property
17.1 km from Main Street Fort Pierce
8.6 out of 10, Excellent, (1,003 reviews)
"My stays there was pretty cool !!"
United States
Pierre Guens
The price is ₩157,410
₩176,299 total
includes taxes & fees
Nov 8 - Nov 9
Holiday Inn Express & Suites Port St. Lucie West by IHG
A hotel lobby with a reception desk, a chandelier, a clock, and a sofa.

13. Sleep Inn Fort Pierce I-95

Sleep Inn Fort Pierce I-95
2.5 star property
7.9 km from Main Street Fort Pierce
7.6 out of 10, Good, (926 reviews)
"Staff was very friendly and rooms were clean"
United States
Charity
The price is ₩95,300
₩106,736 total
includes taxes & fees
Nov 29 - Nov 30
Sleep Inn Fort Pierce I-95
A multi-story hotel with a modern design, featuring a prominent sign for 'Springhill Suites Marriott'.

14. SpringHill Suites Port St. Lucie

SpringHill Suites Port St. Lucie
3.0 star property
17.2 km from Main Street Fort Pierce
8.8 out of 10, Excellent, (1,005 reviews)
"Loved our stay, great staff."
United States
Amy
The price is ₩124,861
₩139,845 total
includes taxes & fees
Nov 8 - Nov 9
SpringHill Suites Port St. Lucie
A hotel lobby with seating areas, a kitchenette, and a view of the outdoors.

15. Hampton Inn & Suites Port St. Lucie, West

Hampton Inn & Suites Port St. Lucie, West
2.5 star property
17.4 km from Main Street Fort Pierce
9.0 out of 10, Wonderful, (1,003 reviews)
"Very Helpful and Friendly staff, our room was super clean, and breakfast was great!"
United States
Ahim
The price is ₩129,263
₩144,775 total
includes taxes & fees
Nov 15 - Nov 16
Hampton Inn & Suites Port St. Lucie, West
A modern living room with a fireplace, a dining area with bar stools, and a large TV mounted on the wall.

16. Hampton Inn & Suites Vero Beach Downtown

Hampton Inn & Suites Vero Beach Downtown
2.5 star property
22.1 km from Main Street Fort Pierce
9.2 out of 10, Wonderful, (1,001 reviews)
"Everything was excellent."
United States
Judith
The price is ₩165,267
₩185,099 total
includes taxes & fees
Dec 1 - Dec 2
Hampton Inn & Suites Vero Beach Downtown
A restaurant interior with a bar area, wooden flooring, and multiple seating arrangements.

17. Days Inn & Suites by Wyndham Fort Pierce Midtown

Days Inn & Suites by Wyndham Fort Pierce Midtown
2.0 star property
4.5 km from Main Street Fort Pierce
9.0 out of 10, Wonderful, (12 reviews)
"Good value"
United States
Cynthia
The price is ₩94,112
₩105,406 total
includes taxes & fees
Nov 2 - Nov 3
Days Inn & Suites by Wyndham Fort Pierce Midtown
A restaurant with a view of the beach and palm trees. Tables are set with chairs and dining tables.

18. Hutchinson Shores Resort & Spa

Hutchinson Shores Resort & Spa
4.5 star property
25.2 km from Main Street Fort Pierce
9.4 out of 10, Exceptional, (1,005 reviews)
"The hotel was very quiet and relaxing."
United States
Ronald
The price is ₩265,462
₩355,493 total
includes taxes & fees
Nov 16 - Nov 17
Hutchinson Shores Resort & Spa
An outdoor seating area with wicker furniture, a fire pit, and palm trees.

19. Staybridge Suites Vero Beach by IHG

Staybridge Suites Vero Beach by IHG
3.0 star property
24.1 km from Main Street Fort Pierce
9.6 out of 10, Exceptional, (724 reviews)
"Perfect stay"
United States
Michelle
The price is ₩165,414
₩185,264 total
includes taxes & fees
Nov 8 - Nov 9
Staybridge Suites Vero Beach by IHG
An outdoor seating area with stone walls, a fire feature, and modern furniture.

20. Home2 Suites by Hilton Vero Beach I-95

Home2 Suites by Hilton Vero Beach I-95
3.0 star property
28.3 km from Main Street Fort Pierce
9.6 out of 10, Exceptional, (581 reviews)
"Very clean, very nicely maintain hotel."
United States
Yvette
The price is ₩123,593
₩138,424 total
includes taxes & fees
Nov 8 - Nov 9
Home2 Suites by Hilton Vero Beach I-95
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in Main Street Fort Pierce

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
A hotel lobby with a large reception desk, multiple seating areas, and a patterned carpet.
Fairfield Inn & Suites by Marriott Fort Pierce
3.0 star property
8.8
Excellent
1,003 reviews
View
A modern hotel lobby with a central seating area, a bar, and a coffee station.
Hampton Inn & Suites Ft. Pierce
2.5 star property
9.2
Wonderful
1,001 reviews
View
An outdoor seating area with fire feature, stone walls, and a view into the building.
Home2 Suites by Hilton Ft. Pierce I-95
3.0 star property
9.4
Exceptional
277 reviews
View
A modern reception area with a long corridor, a reception desk, and a seating area with tables and chairs.
Holiday Inn Express Hotel & Suites Fort Pierce West by IHG
2.5 star property
9.0
Wonderful
907 reviews
View
A pool area with lounge chairs and a hot tub, surrounded by palm trees and a view of the ocean.
Hutchinson Island Hotel
2.5 star property
8.2
Very good
1,371 reviews
View

Where to stay in Main Street Fort Pierce

Find the best Main Street Fort Pierce areas and neighborhoods for the activities you enjoy most.
A coastal area with a narrow waterway, a beach, and residential buildings.

Lakewood Park

While Lakewood Park isn't home to many top sights, McKee Botanical Garden and Avalon State Park are some notable places to visit nearby.

Spanish Lakes Country Club Village

While there might not be top attractions in Spanish Lakes Country Club Village, you can explore the larger area and discover places like Harbor Branch Ocean Discovery Center and McKee Botanical Garden.

A calm lake reflecting trees and a clear sky.

Spanish Lakes Fairways

While Spanish Lakes Fairways might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Lakewood Park Regional Park / Pool and Indrio Road Park / Schoolhouse.

A coastal city with a bay, mangrove islands, and a clear blue sky.

Meadowood

If you're looking for some top things to see and do in Meadowood and surrounding area, you can visit Endless Summer Vineyard & Winery and Al's Family Farms.

A mosaic sign with 'Mainstreet Fort Pierce' written on it.

Panther Woods

If you're looking for some top things to see and do in Panther Woods and surrounding area, you can visit Endless Summer Vineyard & Winery and Al's Family Farms.

Top Main Street Fort Pierce Hotel Reviews

At Home Inn

At Home Inn

10/10 Excellent
"Everything was great!"
John 1-night trip
Posted 1 day ago
At Home Inn

Frequently asked questions

What is Main Street Fort Pierce like?
Main Street Fort Pierce is a neighborhood that travelers like for its waterfront, art, and shopping. Be sure to check out Sunrise Theater and Fort Pierce Farmer's Market as part of your Main Street Fort Pierce travel plans.
How many hotels can I expect to find in Main Street Fort Pierce?
Book one of Expedia's 7 hotels and other accommodations in Main Street Fort Pierce and start exploring everything Fort Pierce has to offer.
If I need to cancel my hotel reservation in Main Street Fort Pierce, will I receive a refund?
Yes! The majority of hotel reservations are fully refundable provided that you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If you booked a non-refundable reservation, you might be able to cancel it and be given a refund within 24 hours of booking. Put your dates in and click on "Search", then use the filter option "fully refundable" to review the top deals on offer in Main Street Fort Pierce.
Where can I learn more about changing or cancelling my trip to Main Street Fort Pierce?
For additional details about changing or cancelling your trip to Main Street Fort Pierce, head over to our customer service page.
What is there to do in this Fort Pierce neighborhood?
Sights like Sunrise Theater and Official Highwaymen Art Gallery can be part of your cultural tour of Main Street Fort Pierce. Fort Pierce Farmer's Market and Fort Pierce City Marina are also a couple of places to visit in the neighborhood. A few places to visit in the area around Main Street Fort Pierce include Manatee Education and Observation Center, House of Seven Gables, and A.E. Backus Museum. Marina at Fort Pierce and Causeway Cove are also worth a visit when you're out sightseeing in Fort Pierce.