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Our top choices for Mayo Clinic Florida hotels

A modern restaurant with a bar area, wooden ceiling, and large windows.
A modern bar area with a central hanging light fixture, bar stools, and a well-stocked liquor display.
A covered outdoor seating area with chairs and sofas, a fountain, and a view of a lake and trees.
A modern lobby with a central seating area, wooden shelving with decorative items, and a large pillar.

1. Hilton Jacksonville at Mayo Clinic near Beaches

Hilton Jacksonville at Mayo Clinic near Beaches
0.8 km from Mayo Clinic Florida
United States
Mercedes
₩207,662
₩235,696 total
includes taxes & fees
Sep 7 - Sep 8
Hilton Jacksonville at Mayo Clinic near Beaches
An outdoor seating area with a fire pit, wicker furniture, and a covered patio.
An outdoor patio with a pool, wooden pergola, and seating area.
A multi-story hotel with a modern design, featuring a covered outdoor area with seating and a fire pit.
A modern kitchen with wooden cabinets, a built-in oven, and a coffee machine.

2. TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East
Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida
United States
Tiffany
₩163,784
₩185,895 total
includes taxes & fees
Sep 17 - Sep 18
TownePlace Suites by Marriott Jacksonville East
A lobby with a reception desk, seating area, and a staircase.
A modern hotel room with a large bed, a blue sofa, a small table, and a wall-mounted lamp.
An indoor swimming pool with clear views of trees outside, a tiled floor, and a covered seating area.

3. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
2.6 km from Mayo Clinic Florida
United States
Geisha
₩139,010
₩157,775 total
includes taxes & fees
Sep 6 - Sep 7
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
An outdoor seating area with stone fire pit, wicker furniture, and potted plants.
A modern hotel lobby with a flat-screen TV, a fireplace, comfortable seating, and a coffee bar.
A hotel pool area with lounge chairs and umbrellas, surrounded by multi-story buildings with balconies.
A bar area with a long counter, multiple stools, and shelves stocked with bottles.

4. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
0.4 km from Mayo Clinic Florida
United States
Troy
₩209,204
₩237,446 total
includes taxes & fees
Sep 12 - Sep 13
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
A swimming pool with a wooden deck, lounge chairs, and umbrellas.
A backyard with a swimming pool, wooden deck, and outdoor furniture.
A hotel room with two beds, a floral wallpaper, a ceiling light, and a wall-mounted air conditioner.
A bathroom with a toilet, sink, and a shower curtain.

5. The Hotel Palms Poolside

The Hotel Palms Poolside
7.8 km from Mayo Clinic Florida
United States
Vinny
₩233,183
₩264,663 total
includes taxes & fees
Sep 3 - Sep 4
The Hotel Palms Poolside
A coastal cityscape with a long beach, a large hotel with a curved facade, and a clear sky.
A Holiday Inn Express building with a modern design, featuring a flat roof, multiple windows, and a clear sky.
A swimming pool with a clear blue water, surrounded by lounge chairs and umbrellas, with a building in the background.
A hotel lobby with a reception desk, seating area, and a large window.

6. Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Holiday Inn Express & Suites Jacksonville - Town Center by IHG
Southside, 7.7 km from Mayo Clinic Florida
United States
Ian
₩180,301
₩204,641 total
includes taxes & fees
Sep 6 - Sep 7
Holiday Inn Express & Suites Jacksonville - Town Center by IHG
An outdoor patio area with seating, a fire pit, and a barbecue grill.
A modern kitchen with wooden cabinets, a central island with jars, and a countertop with toasters.
A reception area with a modern design, featuring a reception desk, a refrigerator with snacks, and a wooden slatted wall.
A modern living room with sofas, a coffee table, and a dining area.

7. TownePlace Suites by Marriott® Jacksonville Mayport

TownePlace Suites by Marriott® Jacksonville Mayport
10.8 km from Mayo Clinic Florida
United States
Paul
₩173,685
₩197,134 total
includes taxes & fees
Sep 13 - Sep 14
TownePlace Suites by Marriott® Jacksonville Mayport
A spacious lobby with a central seating area, large windows, and a fountain.
A hotel room with two beds, a desk, a chair, a TV, and a view of the ocean.
A beach umbrella with two chairs underneath, a sandy beach, and the ocean in the background.

8. Ponte Vedra Inn & Club

Ponte Vedra Inn & Club
6.3 km from Mayo Clinic Florida
United Kingdom
Michael
₩614,052
₩728,896 total
includes taxes & fees
Sep 3 - Sep 4
Ponte Vedra Inn & Club
A spacious lobby with a reception desk, seating area, and large windows.
An indoor dining area with tables and chairs, a ceiling fan, and a view of the outdoors.
A bar area with wooden chairs, a round table, and a brick wall.
A modern coffee shop interior with a central counter, shelves stocked with snacks, and a refrigerated section labeled 'FROZEN' and 'CHILLED'.

9. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
8.5 km from Mayo Clinic Florida
United States
Brooke
₩176,810
₩197,143 total
includes taxes & fees
Sep 10 - Sep 11
Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
A laptop on a wooden desk with a white mug, a spoon, and a smartphone.

10. Hyatt Studios Jacksonville/St Johns Town Center

Hyatt Studios Jacksonville/St Johns Town Center
Deerwood, 7.8 km from Mayo Clinic Florida
United States
Michele
₩150,436
₩170,746 total
includes taxes & fees
Sep 18 - Sep 19
Hyatt Studios Jacksonville/St Johns Town Center
A pool with a waterfall feature, surrounded by large rock formations.
A bar with a tiled roof, outdoor seating, and a view of the ocean.
A beachfront hotel with multiple balconies, a sandy beach, and ocean views.
A hotel with a pool, a parking lot, and a view of the ocean.

11. Hampton Inn Jacksonville Beach/Oceanfront

Hampton Inn Jacksonville Beach/Oceanfront
6.3 km from Mayo Clinic Florida
United States
Kevin
₩219,705
₩249,365 total
includes taxes & fees
Sep 29 - Sep 30
Hampton Inn Jacksonville Beach/Oceanfront
A modern bar area with a central island, multiple seating options, and a variety of bottles displayed on shelves.
An outdoor seating area with white furniture and a well-maintained lawn, surrounded by large windows and a modern building facade.
A modern hotel building with a flat facade, large windows, and a sign reading "ACHTEL JACKSONVILLE".
A modern hotel with a pool, palm trees, and a clear blue sky.

12. AC Hotel Jacksonville St Johns Town Center

AC Hotel Jacksonville St Johns Town Center
Southside, 8.1 km from Mayo Clinic Florida
United States
Alysha
₩244,800
₩277,847 total
includes taxes & fees
Sep 3 - Sep 4
AC Hotel Jacksonville St Johns Town Center
An outdoor seating area with a fire feature, chairs, and a table.
A modern hotel room with two beds, a flat-screen TV, a desk, and a large window with a view of a building.
A modern bar area with a counter, bar stools, and a television screen.
A gym with treadmills, dumbbells, and exercise balls, overlooking a swimming pool.

13. Hotel Indigo Jacksonville-Deerwood Park by IHG

Hotel Indigo Jacksonville-Deerwood Park by IHG
Southside, 10.8 km from Mayo Clinic Florida
United States
stacy
₩174,795
₩198,394 total
includes taxes & fees
Sep 6 - Sep 7
Hotel Indigo Jacksonville-Deerwood Park by IHG
A spacious lobby with a glass floor, a reception desk, and a view of the ocean.
A multi-story hotel with a beach view, parking lot, and a nearby restaurant.
A cafe with a tropical mural, a coffee menu, and a variety of seating options.
A modern building with multiple balconies overlooking a beach.

14. Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach
5.9 km from Mayo Clinic Florida
United States
Natasha
₩204,114
₩231,669 total
includes taxes & fees
Sep 2 - Sep 3
Margaritaville Jacksonville Beach
An outdoor patio with seating, a fire pit, and string lights.
A swimming pool with lounge chairs and umbrellas, surrounded by palm trees and a fence.
A modern living room with a dining area, a flat-screen TV, and a bookshelf.
A multi-story hotel with a modern design, featuring a large number of windows and a flat roof.

15. Hyatt Place Jacksonville / St. Johns Town Center

Hyatt Place Jacksonville / St. Johns Town Center
Southside, 8.6 km from Mayo Clinic Florida
United States
April
₩173,958
₩197,443 total
includes taxes & fees
Sep 3 - Sep 4
Hyatt Place Jacksonville / St. Johns Town Center
A beach with a sandy shore, waves, and buildings in the background.
A Best Western hotel with a modern design, located near a beach with a pier.
A modern cafe with a central counter, seating area, and a wooden accent wall with 'BW' letters.
A modern lobby with a grey sofa, two round tables, a reception desk, and a wooden wall with shelves displaying trophies and awards.

16. Best Western Oceanfront

Best Western Oceanfront
5.7 km from Mayo Clinic Florida
United States
Shawna
₩166,560
₩189,045 total
includes taxes & fees
Sep 2 - Sep 3
Best Western Oceanfront
A pier extending into the ocean at sunset with birds flying above.
A Holiday Inn Express hotel with a clear sky, palm trees, and a parking lot.
A swimming pool with lounge chairs and umbrellas, surrounded by a building with multiple windows and a flat roof.
A hotel lobby with a reception desk, seating area, and a wall with a mountain design.

17. Holiday Inn Express Jacksonville Beach by IHG

Holiday Inn Express Jacksonville Beach by IHG
4.6 km from Mayo Clinic Florida
United States
Beth
₩162,408
₩184,334 total
includes taxes & fees
Sep 9 - Sep 10
Holiday Inn Express Jacksonville Beach by IHG
A Holiday Inn Express sign with a clear sky and sunset in the background.
A rectangular swimming pool with a tiled deck, surrounded by a black metal fence. There are lounge chairs with blue cushions and white frames along the pool's edge.
A reception area with a blue counter, a glass door entrance, a refrigerator stocked with beverages, and a potted plant.
A gym with multiple treadmills, exercise bikes, and a large window providing a view of the outdoors.

18. Holiday Inn Express Jacksonville South Bartram Prk by IHG

Holiday Inn Express Jacksonville South Bartram Prk by IHG
17.1 km from Mayo Clinic Florida
United States
RAYNI
₩132,520
₩150,410 total
includes taxes & fees
Sep 20 - Sep 21
Holiday Inn Express Jacksonville South Bartram Prk by IHG
A coastal hotel with a long promenade, beach access, and a pier in the distance.
A hotel room with a bed, a TV, a wooden dresser, a mirror, and a view of the sea.
A hotel room with a large bed, a desk, a chair, a TV, and a view of the ocean.

19. Four Points by Sheraton Jacksonville Beachfront

Four Points by Sheraton Jacksonville Beachfront
5.6 km from Mayo Clinic Florida
United States
Susan
₩218,838
₩248,382 total
includes taxes & fees
Sep 20 - Sep 21
Four Points by Sheraton Jacksonville Beachfront
A hotel room with a dining area, two beds, a TV, and a kitchenette.
A hotel room with a dining area featuring a table, chairs, a television, a microwave, and a coffee maker.
A compact kitchen with dark cabinetry, a built-in refrigerator, a dining table with a chair, and a wall-mounted lamp.
A hotel with a modern design, featuring a prominent 'Candlewood Suites' sign.

20. Candlewood Suites Jacksonville - Mayport by IHG

Candlewood Suites Jacksonville - Mayport by IHG
9.2 km from Mayo Clinic Florida
United States
Joe
₩161,032
₩182,772 total
includes taxes & fees
Sep 20 - Sep 21
Candlewood Suites Jacksonville - Mayport by IHG
View all properties

Compare popular hotels close to Mayo Clinic Florida

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
A modern restaurant with a bar area, wooden ceiling, and large windows.
Hilton Jacksonville at Mayo Clinic near Beaches
9.4
Exceptional
340 reviews
View
An outdoor seating area with a fire pit, wicker furniture, and a covered patio.
TownePlace Suites by Marriott Jacksonville East
9.2
Wonderful
655 reviews
View
A lobby with a reception desk, seating area, and a staircase.
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
9.0
Wonderful
1,004 reviews
View
An outdoor seating area with stone fire pit, wicker furniture, and potted plants.
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
8.4
Very Good
795 reviews
View
A swimming pool with a wooden deck, lounge chairs, and umbrellas.
The Hotel Palms Poolside
9.8
Exceptional
493 reviews
View

Top Mayo Clinic Florida Hotel Reviews

Best Western Oceanfront

Best Western Oceanfront

10/10 Excellent
"We had a great stay"
Cheryl 4-night trip
Posted 4 hours ago
Best Western Oceanfront
Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

10/10 Excellent
"The staff were very friendly and helpful."
Teressa 1-night trip
Posted 5 hours ago
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

10/10 Excellent
"I needed a hotel close to Mayo Clinic. This hotel was very clean and well maintained. I would definitely recommend."
Kevin 1-night trip
Posted 11 hours ago
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
Hilton Jacksonville at Mayo Clinic near Beaches

Hilton Jacksonville at Mayo Clinic near Beaches

10/10 Excellent
"Staff was burdened with tasks taking them away from guests but they still did a great job. Property is amazing."
Jim 1-night trip
Posted 14 hours ago
Hilton Jacksonville at Mayo Clinic near Beaches
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

10/10 Excellent
"Large rooms, very clean"
Melony 2-night trip
Posted 4 days ago
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

8/10 Good
"Clean room, quiet, helpful staff, good AC."
Stel 1-night trip
Posted 5 days ago
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Frequently asked questions

What's the area like around Mayo Clinic Florida?
Mayo Clinic Florida is located in a welcoming area of Jacksonville known for its beautiful beaches and surfing. If you're looking for a convenient place to stay, check out the 45 hotels and other accommodations you'll find within a mile.
What's the best place to stay close to Mayo Clinic Florida?
Adjacent to Mayo Clinic Florida, Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and an outdoor pool. Other good choices close by include Hilton Jacksonville at Mayo Clinic near Beaches and Residence Inn By Marriott Jacksonville - Mayo Clinic Area.
How many hotels will I find near Mayo Clinic Florida?
Expedia has 45 hotels and other accommodations within a mile from Mayo Clinic Florida.
If I need to cancel the hotel reservation for my stay near Mayo Clinic Florida, will I receive a refund?
Yes, you'll find most hotel reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, you might still have the option to cancel and get a refund within a 24-hour period of your booking. Add your dates and click on "Search", then you can filter by "fully refundable" to review the best deals available near Mayo Clinic Florida.
Where can I learn more about changing or cancelling my trip in the area near Mayo Clinic Florida?
To access more information about picking new dates or cancelling your stay near Mayo Clinic Florida, head over to our customer service page.
What can I see and do near Mayo Clinic Florida?
You can catch a show at SeaWalk Pavillion, Wilson Center For the Arts, and Blue Jay Listening Room. Spend some time exploring the natural beauty of Huguenot Park, Oceanfront Park, and Cradle Creek Preserve. Lounge by the water at Northeast Florida Beaches and Ponte Vedra Beach.