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Discover Santa Ana hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Luxury Apartment | Balcony
Casco View Apartments

Casco View Apartments

3.5 star property
Santa Ana
9.2 out of 10, Wonderful, (50)
"Great stay, would recommend."
United States
Brooke
Casco View Apartments
Balcony
Hotel República

Hotel República

2.0 star property
Santa Ana
6.6 out of 10, (180)
"Fantastic customer service"
United States
OLGA
Hotel República
Front of property
ART CASCO The Hotel

ART CASCO The Hotel

2.0 star property
Santa Ana
5.8 out of 10, (10)
"Walkable location and free secure parking! The price is really affordable, but the condition of the hotel is not the best"
United States
Eldris
ART CASCO The Hotel
Bar (on property)
Hostal La Cigarra

Hostal La Cigarra

2.0 star property
Santa Ana
7.6 out of 10, Good, (54)
"Helpful staff, secure, close to sights"
Australia
Suzanne
The price is ₩37,304
₩41,040 total
includes taxes & fees
Nov 23 - Nov 24
Hostal La Cigarra
Apartment (20) | 1 bedroom, iron/ironing board, free WiFi, bed sheets
La Manzana by Wynwood House

La Manzana by Wynwood House

3.0 star property
Santa Ana
7.2 out of 10, Good, (15)
"Great hotel. Very close to Casco viejo"
United States
LUCILA
The price is ₩76,197
₩113,237 total
includes taxes & fees
Nov 23 - Nov 24
La Manzana by Wynwood House
Room, Multiple Bedrooms, Accessible, Smoking | Pool | Outdoor pool
Room-sofa Bed Stay Rooftop Pool & Gym, A

Room-sofa Bed Stay Rooftop Pool & Gym, A

2.0 star property
Santa Ana
2.0 out of 10, (1)
"You pay for a space in the apartment, it’s not the whole apartment be careful. The owner or whoever manages doesn’t give care about you as costumers they just want the money"
United States
Cristian Camilo Betancur
The price is ₩215,473
₩237,020 total
includes taxes & fees
Nov 23 - Nov 24
Room-sofa Bed Stay Rooftop Pool & Gym, A
Apartment | Terrace/patio
Casa Quijano 06 By Wynwood House

Casa Quijano 06 By Wynwood House

4.0 star property
Santa Ana
9.0 out of 10, Wonderful, (4)
"Easy to find, seamless check-in "
Canada
Matthew
The price is ₩121,660
₩182,431 total
includes taxes & fees
Dec 15 - Dec 16
Casa Quijano 06 By Wynwood House
Outdoor pool, pool umbrellas, sun loungers
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4.0 star property
21.1 km from Santa Ana
8.4 out of 10, Very Good, (2283)
"Spacious room, clean, good breakfast "
United States
Juan
The price is ₩151,805
₩191,257 total
includes taxes & fees
Nov 24 - Nov 25
Crowne Plaza Panama Airport by IHG
47-inch flat-screen TV with cable channels, TV
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4.0 star property
San Felipe, 0.9 km from Santa Ana
9.0 out of 10, Wonderful, (1003)
"Hotel was beautiful, staff was very helpful and accommodating. We had the pool two separate days to ourselves. Breakfadt was very good. Staff was very helpful getting us drivers wherever we wanted to go in the city."
United States
MICHELE
Central Hotel Panama Casco Viejo
Front of property
La Concordia Boutique Hotel

La Concordia Boutique Hotel

4.0 star property
San Felipe, 0.5 km from Santa Ana
9.6 out of 10, Exceptional, (192)
"The staff was very friendly and supportive. The room was spectacular! It was beautifully decorated and very clean. It was just a delight to stay in this lovely hotel!"
United States
Madelaine
La Concordia Boutique Hotel
Reception
Hotel Coral Suites

Hotel Coral Suites

3.5 star property
El Cangrejo, 3.7 km from Santa Ana
9.0 out of 10, Wonderful, (1002)
"Great place for the price. "
United States
Ryan
The price is ₩101,938
₩112,132 total
includes taxes & fees
Nov 23 - Nov 24
Hotel Coral Suites
View from property
Waldorf Astoria Panama

Waldorf Astoria Panama

5.0 star property
Bella Vista, 2.9 km from Santa Ana
9.0 out of 10, Wonderful, (1004)
"Very beautiful room was spotless, and staff was very good with customer service"
United States
Anthony
The price is ₩252,097
₩277,307 total
includes taxes & fees
Dec 6 - Dec 7
Waldorf Astoria Panama
3 outdoor pools, pool umbrellas, sun loungers
The Westin Playa Bonita Panama

The Westin Playa Bonita Panama

5.0 star property
7.5 km from Santa Ana
8.0 out of 10, Very Good, (1003)
"Staff very friendly, clean room, amazing food&drinks"
United States
Ashley Ethel
The price is ₩244,653
₩269,118 total
includes taxes & fees
Dec 14 - Dec 15
The Westin Playa Bonita Panama
Front of property - evening/night
Principe Hotel and Suites

Principe Hotel and Suites

3.0 star property
El Cangrejo, 3.9 km from Santa Ana
9.0 out of 10, Wonderful, (1557)
"A nice hotel with plenty of shopping and restaurants in the area"
United States
Neil
The price is ₩73,549
₩80,904 total
includes taxes & fees
Dec 7 - Dec 8
Principe Hotel and Suites
Outdoor pool, sun loungers
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5.0 star property
Campo Alegre, 3.6 km from Santa Ana
9.0 out of 10, Wonderful, (4559)
"Great place to stay "
United States
yohosy
The price is ₩174,547
₩192,002 total
includes taxes & fees
Dec 7 - Dec 8
Hotel Riu Plaza Panama
Outdoor pool, open 9:00 AM to 9:00 PM, sun loungers
Hospedium Princess Hotel Panama

Hospedium Princess Hotel Panama

3.5 star property
Obarrio, 3.6 km from Santa Ana
7.6 out of 10, Good, (680)
"The breakfast was great, I love the pool."
United States
Estefani
The price is ₩81,551
₩89,706 total
includes taxes & fees
Dec 8 - Dec 9
Hospedium Princess Hotel Panama
Outdoor spa tub
TRYP by Wyndham Panamá Centro

TRYP by Wyndham Panamá Centro

3.5 star property
El Cangrejo, 3.5 km from Santa Ana
9.2 out of 10, Wonderful, (1010)
"Staff was helpful, room was clean and I enjoyed my stay. "
United States
Lystra
The price is ₩113,265
₩124,592 total
includes taxes & fees
Dec 8 - Dec 9
TRYP by Wyndham Panamá Centro
View from property
Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel

3.5 star property
Punta Paitilla, 3.4 km from Santa Ana
9.4 out of 10, Exceptional, (2143)
"Very nice hotel, all amenities met our needs. "
Canada
gordon
The price is ₩124,370
₩136,807 total
includes taxes & fees
Dec 6 - Dec 7
Plaza Paitilla Inn Hotel
Front of property
Novotel Panama City

Novotel Panama City

4.0 star property
El Cangrejo, 4.3 km from Santa Ana
9.2 out of 10, Wonderful, (1008)
"Room very clean, nice staffs and good location "
United States
Hayden
The price is ₩132,388
₩145,627 total
includes taxes & fees
Dec 9 - Dec 10
Novotel Panama City
Living area
ORHO HOTEL BOUTIQUE PANAMA Airport

ORHO HOTEL BOUTIQUE PANAMA Airport

2.0 star property
20.5 km from Santa Ana
8.8 out of 10, Excellent, (28)
"Very nice boutique hotel"
United States
Fernando
The price is ₩176,518
₩194,170 total
includes taxes & fees
Nov 23 - Nov 24
ORHO HOTEL BOUTIQUE PANAMA Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most.

Casco Viejo

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Interoceanic Canal Museum or National Theater while you're exploring the area.

Bella Vista

Bella Vista is highly notable for its popular shops, and you might want to visit top sights like Via Espana and Iglesia del Carmen. See more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina.

El Cangrejo

The abundant dining options and casinos are top of the list for many visitors to El Cangrejo. A stop by Crown Casino or Luxor Towers might round out your trip.

San Francisco

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

San Felipe

If you're spending some time in San Felipe, Independence Square and Interoceanic Canal Museum are top sights worth seeing.

Top Santa Ana Hotel Reviews

Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

10/10 Excellent
"Yes"
chinelle 3-night trip
Posted 11 hours ago
Crowne Plaza Panama Airport by IHG

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Frequently asked questions

What's it like in Santa Ana?
Santa Ana is a neighborhood that travelers like for its seafood restaurants, shopping, and parks. Are you looking for Santa Ana travel tips? Be sure to check out Cinta Costera and Avenida Balboa while you're in the neighborhood.
Where is the best hotel for a stay in Santa Ana?
Based on Expedia customer reviews, Hotel República is the highest ranked property in Santa Ana. This hotel is a short 4-minute walk from Avenida Balboa, and it offers a rooftop terrace and free WiFi. Another top choice in the area is Hostal La Cigarra.
How many hotels can I expect to find in Santa Ana?
Expedia has 112 hotels and other accommodations in Santa Ana to choose from, making this an ideal home base for exploring the greater Panama City area.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! Most hotel room reservations are refundable provided that you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you have a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of your booking. Add dates, click "Search", then use the "fully refundable" filter to get top deals in Santa Ana.
Where can I learn more about changing or cancelling my trip to Santa Ana?
To find more details about picking new dates or cancelling your trip to Santa Ana, head over to our customer service page.
What is there to do in this Panama City neighborhood?
If you're looking forward to a day of shopping in Santa Ana, consider Avenida Central or Avenida Balboa, and pick out the perfect souvenir. A visit to Cinta Costera is also worth the trip while you're discovering the neighborhood. Albrook Shopping Mall, Amador Theater, and Museum of Contemporary Art Panama are just a few of the places to visit in and around Santa Ana. When you're sightseeing in Panama City, Mi Pueblito and Iglesia de la Merced are also worth a stop.