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Our top choices for Santa Ana hotels

Hostal La Cigarra

Hostal La Cigarra
2.0 star property
Santa Ana
7.4 out of 10, Good, (56)
"Excelente "
Mexico
David
The price is ₩36,757
₩40,439 total
includes taxes & fees
Jan 10 - Jan 11
Hostal La Cigarra

Casco View Apartments

Casco View Apartments
3.5 star property
Santa Ana
9.0 out of 10, Wonderful, (61)
"We live this property and stay here whenever we are in town."
United States
chris
Casco View Apartments

Hotel República

Hotel República
2.0 star property
Santa Ana
6.6 out of 10, (182)
"Fantastic customer service"
United States
OLGA
Hotel República

La Manzana by Wynwood House

La Manzana by Wynwood House
3.0 star property
Santa Ana
7.2 out of 10, Good, (15)
"Great hotel. Very close to Casco viejo"
United States
LUCILA
The price is ₩88,705
₩137,435 total
includes taxes & fees
Feb 1 - Feb 2
La Manzana by Wynwood House

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama
5.0 star property
Campo Alegre, 3.6 km from Santa Ana
9.0 out of 10, Wonderful, (4801)
"Great place to stay"
United States
Maria Teresa
The price is ₩177,492
₩195,241 total
includes taxes & fees
Jan 18 - Jan 19
Hotel Riu Plaza Panama

Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG
4.0 star property
20.5 km from Santa Ana
8.6 out of 10, Excellent, (2385)
"Great staff and close to the airport "
United States
CARLOS ROBERTO
The price is ₩159,436
₩175,380 total
includes taxes & fees
Jan 15 - Jan 16
Crowne Plaza Panama Airport by IHG

Radisson Hotel Panama Canal

Radisson Hotel Panama Canal
4.5 star property
Amador, 2.3 km from Santa Ana
8.4 out of 10, Very Good, (1015)
"Unbeatable location if your visit is all about the Panama Canal. "
United States
Vitaliy
The price is ₩108,726
₩119,599 total
includes taxes & fees
Feb 7 - Feb 8
Radisson Hotel Panama Canal

Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino
4.0 star property
19.8 km from Santa Ana
8.6 out of 10, Excellent, (1845)
"Better than expected: Location, transportation to and from airport, pool area tropical and comfortable. "
United States
Marty
The price is ₩181,251
₩199,376 total
includes taxes & fees
Jan 13 - Jan 14
Riande Aeropuerto Hotel & Casino

ORHO HOTEL BOUTIQUE PANAMA Airport

ORHO HOTEL BOUTIQUE PANAMA Airport
2.5 star property
20.5 km from Santa Ana
9.0 out of 10, Wonderful, (46)
"Great staff and nice boutique hotel "
United States
Margie
The price is ₩173,930
₩225,761 total
includes taxes & fees
Jan 10 - Jan 11
ORHO HOTEL BOUTIQUE PANAMA Airport

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
5.0 star property
Juan Diaz, 12.7 km from Santa Ana
9.6 out of 10, Exceptional, (650)
"As usual the stay was amazing in this hotel"
United States
Jose
The price is ₩325,959
₩358,562 total
includes taxes & fees
Jan 25 - Jan 26
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

Courtyard by Marriott Panama Metromall

Courtyard by Marriott Panama Metromall
4.0 star property
14.7 km from Santa Ana
8.8 out of 10, Excellent, (1003)
"Very courteous staff - early check in - room clean "
United States
Arthur
The price is ₩147,027
₩161,730 total
includes taxes & fees
Feb 6 - Feb 7
Courtyard by Marriott Panama Metromall

W Panama

W Panama
5.0 star property
Campo Alegre, 3.2 km from Santa Ana
9.0 out of 10, Wonderful, (1001)
"Beautiful room, super clean, and friendly staff!!!"
United States
Kimberly
The price is ₩282,352
₩310,587 total
includes taxes & fees
Feb 7 - Feb 8
W Panama

Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica
4.0 star property
San Francisco, 5.1 km from Santa Ana
9.6 out of 10, Exceptional, (1142)
"The room was clean and the location was great."
United States
Wendy
The price is ₩157,697
₩173,467 total
includes taxes & fees
Jan 10 - Jan 11
Ramada Plaza by Wyndham Panama Punta Pacifica

Sortis Hotel, Spa & Casino, Autograph Collection by Marriott

Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
4.5 star property
Obarrio, 4.1 km from Santa Ana
8.8 out of 10, Excellent, (1012)
"Great hotel. Great spa"
United States
Robert
The price is ₩195,672
₩215,239 total
includes taxes & fees
Jan 16 - Jan 17
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott

Riande Urban Hotel

Riande Urban Hotel
3.5 star property
El Cangrejo, 3.8 km from Santa Ana
8.8 out of 10, Excellent, (1046)
"Good hotel and nice staff"
United States
Jose
The price is ₩121,903
₩134,093 total
includes taxes & fees
Jan 10 - Jan 11
Riande Urban Hotel

Principe Hotel and Suites

Principe Hotel and Suites
3.0 star property
El Cangrejo, 3.9 km from Santa Ana
9.0 out of 10, Wonderful, (1640)
"A easy and convenient stay"
United States
Dave
The price is ₩84,791
₩93,270 total
includes taxes & fees
Jan 12 - Jan 13
Principe Hotel and Suites

The Executive Hotel

The Executive Hotel
3.5 star property
Campo Alegre, 3.2 km from Santa Ana
9.2 out of 10, Wonderful, (1001)
"A nice hotel to stay great location"
United States
angela
The Executive Hotel

Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel
3.5 star property
Punta Paitilla, 3.4 km from Santa Ana
9.4 out of 10, Exceptional, (2148)
"Great location of the hotel with a lovely breakfast and friendly staff"
United States
fouad
The price is ₩156,465
₩172,112 total
includes taxes & fees
Jan 18 - Jan 19
Plaza Paitilla Inn Hotel

JW Marriott Panama

JW Marriott Panama
5.0 star property
Punta Pacifica, 4.3 km from Santa Ana
9.0 out of 10, Wonderful, (1004)
"Great Hotel and great staff"
United States
Rudolph
The price is ₩434,611
₩478,072 total
includes taxes & fees
Feb 7 - Feb 8
JW Marriott Panama

Hyatt Regency Panama City

Hyatt Regency Panama City
4.5 star property
Campo Alegre, 3.3 km from Santa Ana
9.8 out of 10, Exceptional, (162)
"Breakfast was so good , hotel was clean "
United States
ankit
The price is ₩227,197
₩249,917 total
includes taxes & fees
Jan 10 - Jan 11
Hyatt Regency Panama City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most.

Casco Viejo

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Interoceanic Canal Museum or National Theater while you're exploring the area.

Bella Vista

Bella Vista is highly notable for its popular shops, and you might want to visit top sights like Via Espana and Crown Casino. See more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina.

El Cangrejo

The abundant dining options and casinos are top of the list for many visitors to El Cangrejo. A stop by Crown Casino or Luxor Towers might round out your trip.

San Felipe

If you're spending some time in San Felipe, Interoceanic Canal Museum and National Theater are top sights worth seeing.

San Francisco

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

Top Santa Ana Hotel Reviews

Frequently asked questions

What's it like in Santa Ana?
Santa Ana is a neighborhood that travelers like for its seafood restaurants, shopping, and parks. Are you looking for Santa Ana travel tips? Be sure to check out Cinta Costera and Avenida Balboa while you're in the neighborhood.
Where is the best hotel for a stay in Santa Ana?
Based on Expedia customer reviews, Hotel República is the highest ranked property in Santa Ana. This hotel is a short 4-minute walk from Avenida Balboa, and it offers a rooftop terrace and free WiFi. Another top choice in the area is Hostal La Cigarra.
How many hotels can I expect to find in Santa Ana?
Expedia has 112 hotels and other accommodations in Santa Ana to choose from, making this an ideal home base for exploring the greater Panama City area.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! Most hotel room reservations are refundable provided that you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you have a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of your booking. Add dates, click "Search", then use the "fully refundable" filter to get top deals in Santa Ana.
Where can I learn more about changing or cancelling my trip to Santa Ana?
To find more details about picking new dates or cancelling your trip to Santa Ana, head over to our customer service page.
What is there to do in this Panama City neighborhood?
If you're looking forward to a day of shopping in Santa Ana, consider Avenida Central or Avenida Balboa, and pick out the perfect souvenir. A visit to Cinta Costera is also worth the trip while you're discovering the neighborhood. Albrook Shopping Mall, Amador Theater, and Museum of Contemporary Art Panama are just a few of the places to visit in and around Santa Ana. When you're sightseeing in Panama City, Mi Pueblito and Iglesia de la Merced are also worth a stop.