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Discover 1,527 Santa Ana hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Casco View Apartments
Luxury Apartment | Balcony

Casco View Apartments

3.5 star property
9.4 out of 10, Exceptional, (48)
"Great stay, would recommend."
The price is ₩102,458
₩112,704 total
includes taxes & fees
Oct 9 - Oct 10
Casco View Apartments
Hotel República
Balcony

Hotel República

2.0 star property
6.6 out of 10, (176)
"Fantastic customer service"
The price is ₩41,365
₩45,509 total
includes taxes & fees
Oct 9 - Oct 10
Hotel República
ART CASCO The Hotel
Front of property

ART CASCO The Hotel

2.0 star property
6.6 out of 10, (8)
"Walkable location and free secure parking! The price is really affordable, but the condition of the hotel is not the best"
The price is ₩52,068
₩57,275 total
includes taxes & fees
Oct 9 - Oct 10
ART CASCO The Hotel
Hostal La Cigarra
Bar (on property)

Hostal La Cigarra

2.5 star property
7.4 out of 10, Good, (53)
"Helpful staff, secure, close to sights"
The price is ₩31,876
₩35,058 total
includes taxes & fees
Oct 9 - Oct 10
Hostal La Cigarra
Hotel Riazor
Single Room | Free WiFi, bed sheets

Hotel Riazor

3.0 star property
3.8 out of 10, (11)
"Rough neighborhood "
The price is ₩38,183
₩42,001 total
includes taxes & fees
Oct 9 - Oct 10
Hotel Riazor
La Manzana by Wynwood House
Apartment (20) | 1 bedroom, iron/ironing board, free WiFi, bed sheets

La Manzana by Wynwood House

3.0 star property
7.0 out of 10, Good, (14)
"Great hotel. Very close to Casco viejo"
The price is ₩67,881
₩102,953 total
includes taxes & fees
Oct 12 - Oct 13
La Manzana by Wynwood House
Room-sofa Bed Stay Rooftop Pool & Gym, A
Room, Multiple Bedrooms, Accessible, Smoking | Pool | Outdoor pool

Room-sofa Bed Stay Rooftop Pool & Gym, A

2.0 star property
2.0 out of 10, (1)
"You pay for a space in the apartment, it’s not the whole apartment be careful. The owner or whoever manages doesn’t give care about you as costumers they just want the money"
The price is ₩208,048
₩228,853 total
includes taxes & fees
Oct 9 - Oct 10
Room-sofa Bed Stay Rooftop Pool & Gym, A
Crowne Plaza Panama Airport by IHG
Outdoor pool, pool umbrellas, sun loungers

Crowne Plaza Panama Airport by IHG

4.0 star property
8.4 out of 10, Very Good, (2235)
"near airport, staff super helpful "
The price is ₩151,601
₩166,761 total
includes taxes & fees
Nov 1 - Nov 2
Crowne Plaza Panama Airport by IHG
Central Hotel Panama Casco Viejo
47-inch flat-screen TV with cable channels, TV

Central Hotel Panama Casco Viejo

4.0 star property
9.0 out of 10, Wonderful, (1002)
"Very beautiful hotel with helpful staff. Very good dining options. "
The price is ₩217,163
₩238,879 total
includes taxes & fees
Oct 27 - Oct 28
Central Hotel Panama Casco Viejo
La Concordia Boutique Hotel
Exclusive House | Terrace/patio

La Concordia Boutique Hotel

4.0 star property
9.4 out of 10, Exceptional, (184)
"Beautiful boutique hotel. Our room was large, bed is comfortable, nice selection of pillows, large balcony. Hotel staff is friendly and helpful. I highly recommend this place."
The price is ₩236,167
₩259,784 total
includes taxes & fees
Oct 10 - Oct 11
La Concordia Boutique Hotel
TRYP by Wyndham Panamá Centro
Exterior

TRYP by Wyndham Panamá Centro

3.5 star property
9.0 out of 10, Wonderful, (1008)
"Staff was very friendly and breakfast option were wide"
The price is ₩115,397
₩126,937 total
includes taxes & fees
Oct 14 - Oct 15
TRYP by Wyndham Panamá Centro
Hotel Coral Suites
Reception

Hotel Coral Suites

3.5 star property
9.0 out of 10, Wonderful, (1001)
"Great location with spacious rooms "
The price is ₩98,003
₩107,803 total
includes taxes & fees
Oct 9 - Oct 10
Hotel Coral Suites
Hotel Riu Plaza Panama
Outdoor pool, sun loungers

Hotel Riu Plaza Panama

5.0 star property
9.0 out of 10, Wonderful, (4354)
"Excellent stay!!"
The price is ₩167,808
₩184,589 total
includes taxes & fees
Nov 5 - Nov 6
Hotel Riu Plaza Panama
Megapolis Hotel Panamá
Front of property

Megapolis Hotel Panamá

4.5 star property
8.4 out of 10, Very Good, (1110)
"Great place "
The price is ₩182,457
₩200,703 total
includes taxes & fees
Oct 31 - Nov 1
Megapolis Hotel Panamá
Riande Aeropuerto Hotel & Casino
Outdoor pool, open 7:00 AM to 10:30 PM, free cabanas, pool umbrellas

Riande Aeropuerto Hotel & Casino

4.0 star property
8.6 out of 10, Excellent, (1898)
"Nice hotel, close to the airport, friendly staff"
The price is ₩270,464
₩297,510 total
includes taxes & fees
Oct 9 - Oct 10
Riande Aeropuerto Hotel & Casino
Principe Hotel and Suites
Front of property - evening/night

Principe Hotel and Suites

3.0 star property
9.0 out of 10, Wonderful, (1499)
"Great place to stay"
The price is ₩72,123
₩79,335 total
includes taxes & fees
Oct 13 - Oct 14
Principe Hotel and Suites
Novotel Panama City
Front of property

Novotel Panama City

4.0 star property
9.0 out of 10, Wonderful, (1011)
"Love the great stretch of restaurants nearby, within walkable distance"
The price is ₩137,459
₩151,205 total
includes taxes & fees
Oct 31 - Nov 1
Novotel Panama City
Hospedium Princess Hotel Panama
Outdoor pool, open 9:00 AM to 9:00 PM, sun loungers

Hospedium Princess Hotel Panama

3.5 star property
7.6 out of 10, Good, (634)
"The property itself was clean and felt safe. Convenient location close to different restaurants and ease of transportation options."
The price is ₩78,403
₩86,243 total
includes taxes & fees
Oct 9 - Oct 10
Hospedium Princess Hotel Panama
Bristol Panama, a Registry Collection Hotel
Couples treatment rooms, sauna, steam room, body treatments

Bristol Panama, a Registry Collection Hotel

5.0 star property
9.2 out of 10, Wonderful, (1002)
"We had an amazing time, great hotel and great breakfast. "
The price is ₩252,433
₩277,676 total
includes taxes & fees
Nov 7 - Nov 8
Bristol Panama, a Registry Collection Hotel
Plaza Paitilla Inn Hotel
View from property

Plaza Paitilla Inn Hotel

3.5 star property
9.4 out of 10, Exceptional, (2115)
"Stayed 4 nights excellent property and views from the room"
The price is ₩213,551
₩234,906 total
includes taxes & fees
Oct 9 - Oct 10
Plaza Paitilla Inn Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most.

Casco Viejo

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Interoceanic Canal Museum or National Theater while you're exploring the area.

Bella Vista

Bella Vista is highly notable for its popular shops, and you might want to visit top sights like Via Espana and Iglesia del Carmen. See more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina.

El Cangrejo

The abundant dining options and casinos are top of the list for many visitors to El Cangrejo. A stop by Crown Casino or Luxor Towers might round out your trip.

San Francisco

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

Punta Paitilla

Travelers come to Punta Paitilla for its abundant dining options, and you can see top attractions like Avenida Balboa and Multicentro Panama while you're in town.

Top Santa Ana Hotel Reviews

Principe Hotel and Suites

Principe Hotel and Suites

10/10 Excellent
"Comfortable and affordable "
James 1-night trip
Posted 23 hours ago
Principe Hotel and Suites

Explore a world of travel with Expedia

Explore a world of travel with Expedia

Frequently asked questions

What's it like in Santa Ana?
Santa Ana is a neighborhood that travelers like for its seafood restaurants, shopping, and parks. Are you looking for Santa Ana travel tips? Be sure to check out Cinta Costera and Avenida Balboa while you're in the neighborhood.
Where is the best hotel for a stay in Santa Ana?
Based on Expedia customer reviews, Hotel República is the highest ranked property in Santa Ana. This hotel is a short 4-minute walk from Avenida Balboa, and it offers a rooftop terrace and free WiFi. Another top choice in the area is Hostal La Cigarra.
How many hotels can I expect to find in Santa Ana?
Expedia has 117 hotels and other accommodations in Santa Ana to choose from, making this an ideal home base for exploring the greater Panama City area.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! Most hotel room reservations are refundable provided that you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you have a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of your booking. Add dates, click "Search", then use the "fully refundable" filter to get top deals in Santa Ana.
Where can I learn more about changing or cancelling my trip to Santa Ana?
To find more details about picking new dates or cancelling your trip to Santa Ana, head over to our customer service page.
What is there to do in this Panama City neighborhood?
If you're looking forward to a day of shopping in Santa Ana, consider Avenida Central or Avenida Balboa, and pick out the perfect souvenir. A visit to Cinta Costera is also worth the trip while you're discovering the neighborhood. Albrook Shopping Mall, Amador Theater, and Museum of Contemporary Art Panama are just a few of the places to visit in and around Santa Ana. When you're sightseeing in Panama City, Mi Pueblito and Iglesia de la Merced are also worth a stop.