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Discover 1,516 Santa Ana hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

ART CASCO The Hotel
ART CASCO The Hotel

Casco View Apartments
Casco View Apartments

Hotel República
Hotel República

Hostal La Cigarra
Hostal La Cigarra

Hotel Riazor
Hotel Riazor

La Manzana by Wynwood House
La Manzana by Wynwood House
Where to stay in Santa Ana
Casco Viejo
Unique features of Casco Viejo include the historic sites and bars. Make a stop by Metropolitan Cathedral of Panama or Interoceanic Canal Museum while you're exploring the area.

Bella Vista
Bella Vista is highly notable for its popular shops, and you might want to visit top sights like Via Espana and Iglesia del Carmen. See more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina.
El Cangrejo
The abundant dining options and casinos are top of the list for many visitors to El Cangrejo. A stop by Crown Casino or Luxor Towers might round out your trip.
Punta Paitilla
Travelers come to Punta Paitilla for its abundant dining options, and you can see top attractions like Avenida Balboa and Multicentro Panama while you're in town.
San Francisco
San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Hotels in top Panama City neighborhoods
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