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Our top choices for Santa Ana hotels

Casco View Apartments

Casco View Apartments
3.5 star property
Santa Ana
9.0 out of 10, Wonderful, (64 reviews)
"We live this property and stay here whenever we are in town."
United States
chris
Casco View Apartments

La Manzana by Wynwood House

La Manzana by Wynwood House
3.0 star property
Santa Ana
7.2 out of 10, Good, (15 reviews)
"Great hotel. Very close to Casco viejo"
United States
LUCILA
The price is ₩97,578
₩147,627 total
includes taxes & fees
Jan 25 - Jan 26
La Manzana by Wynwood House

Hostal La Cigarra

Hostal La Cigarra
2.0 star property
Santa Ana
7.6 out of 10, Good, (59 reviews)
"Excelente "
Mexico
David
The price is ₩37,156
₩40,877 total
includes taxes & fees
Jan 25 - Jan 26
Hostal La Cigarra

Hotel República

Hotel República
2.0 star property
Santa Ana
6.6 out of 10, (182 reviews)
"Super outdated. Looks dangerous in the area"
United States
Nina Kristine
Hotel República

Sortis Hotel, Spa & Casino, Autograph Collection by Marriott

Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
4.5 star property
Obarrio, 4.1 km from Santa Ana
8.8 out of 10, Excellent, (1,001 reviews)
"Great hotel"
United States
Hugh
The price is ₩232,956
₩256,252 total
includes taxes & fees
Feb 16 - Feb 17
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott

Hilton Panama

Hilton Panama
5.0 star property
Bella Vista, 3 km from Santa Ana
8.8 out of 10, Excellent, (1,006 reviews)
"Huge hotel wit"
United States
Katya
The price is ₩315,062
₩346,562 total
includes taxes & fees
Feb 17 - Feb 18
Hilton Panama

Taboga Palace Spa Hotel

Taboga Palace Spa Hotel
3.5 star property
17.7 km from Santa Ana
9.2 out of 10, Wonderful, (41 reviews)
"David and his wife provide a truly fantastic at such a quaint and beautiful property. The pool and views are incredible. We are having such a great time and plan to return in the future."
Canada
Marc-Andre
The price is ₩190,467
₩209,514 total
includes taxes & fees
Jan 25 - Jan 26
Taboga Palace Spa Hotel

Megapolis Hotel Panamá

Megapolis Hotel Panamá
4.5 star property
Punta Paitilla, 3.5 km from Santa Ana
8.4 out of 10, Very Good, (1,386 reviews)
"Clean room,helpful staff around the hotel,good food options"
United States
Umar
Megapolis Hotel Panamá

Gran Evenia Panama

Gran Evenia Panama
4.5 star property
El Cangrejo, 3.8 km from Santa Ana
9.2 out of 10, Wonderful, (207 reviews)
"Great location and great staff. "
United States
Shaunqualia Lakice
Gran Evenia Panama

Arcadia Condo Suites

Arcadia Condo Suites
2.5 star property
Costa del Este, 10.2 km from Santa Ana
9.2 out of 10, Wonderful, (199 reviews)
"Really loved this place"
United States
Alejandra
The price is ₩123,950
₩265,569 total
includes taxes & fees
Jan 27 - Jan 28
Arcadia Condo Suites

ORHO HOTEL BOUTIQUE PANAMA Airport

ORHO HOTEL BOUTIQUE PANAMA Airport
2.5 star property
20.5 km from Santa Ana
9.0 out of 10, Wonderful, (54 reviews)
"Great staff and nice boutique hotel "
United States
Margie
The price is ₩175,816
₩228,209 total
includes taxes & fees
Jan 26 - Jan 27
ORHO HOTEL BOUTIQUE PANAMA Airport

MARINN PLACE Financial District

MARINN PLACE Financial District
3.5 star property
Campo Alegre, 3.3 km from Santa Ana
9.2 out of 10, Wonderful, (303 reviews)
"Second stay, very nice"
Canada
Xiaozhi
MARINN PLACE Financial District

JW Marriott Panama

JW Marriott Panama
5.0 star property
Punta Pacifica, 4.3 km from Santa Ana
9.0 out of 10, Wonderful, (1,007 reviews)
"The staff was very friendly and the whole property made you feel Safe!"
United States
Michael
The price is ₩408,771
₩449,648 total
includes taxes & fees
Feb 6 - Feb 7
JW Marriott Panama

Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City
5.0 star property
San Felipe, 1.1 km from Santa Ana
9.8 out of 10, Exceptional, (579 reviews)
"The staf, the people on the main entrance door, the concierne, everything is perfect. "
United States
alejandro
The price is ₩479,464
₩527,418 total
includes taxes & fees
Feb 23 - Feb 24
Sofitel Legend Casco Viejo, Panama City

Hotel La Compañía Casco Antiguo

Hotel La Compañía Casco Antiguo
4.5 star property
San Felipe, 0.9 km from Santa Ana
9.8 out of 10, Exceptional, (265 reviews)
"Great location!"
United States
Erik
The price is ₩508,400
₩559,240 total
includes taxes & fees
Feb 17 - Feb 18
Hotel La Compañía Casco Antiguo

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
5.0 star property
Juan Diaz, 12.7 km from Santa Ana
9.6 out of 10, Exceptional, (658 reviews)
"As usual the stay was amazing in this hotel"
United States
Jose
The price is ₩317,567
₩349,331 total
includes taxes & fees
Feb 15 - Feb 16
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

Villa Caprichosa

Villa Caprichosa
3.0 star property
18.3 km from Santa Ana
9.8 out of 10, Exceptional, (45 reviews)
"Would definitely visit again "
United States
John
The price is ₩366,283
₩402,911 total
includes taxes & fees
Jan 25 - Jan 26
Villa Caprichosa

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo
4.0 star property
San Felipe, 0.9 km from Santa Ana
9.2 out of 10, Wonderful, (1,000 reviews)
"Friendly staff nice rooms "
United States
Erin
The price is ₩627,749
₩690,524 total
includes taxes & fees
Jan 29 - Jan 30
Central Hotel Panama Casco Viejo

Oasis Hotel

Oasis Hotel
3.0 star property
San Felipe, 0.6 km from Santa Ana
8.4 out of 10, Very Good, (112 reviews)
"Our stay was exceptional! The room was clean, bed comfortable, amazing balcony view, very sweet staff, fun rooftop bar with delicious food. Definitely recommend staying at The Oasis."
United States
Michele
The price is ₩108,786
₩119,672 total
includes taxes & fees
Jan 26 - Jan 27
Oasis Hotel

Magnolia Inn

Magnolia Inn
2.0 star property
San Felipe, 0.7 km from Santa Ana
8.8 out of 10, Excellent, (430 reviews)
"Location location location. Also, the common area and kitchen were very nice. We really appreciated the staffs willingness to store our bags prior to check in. "
United States
James
The price is ₩135,460
₩149,006 total
includes taxes & fees
Jan 26 - Jan 27
Magnolia Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most.

Casco Viejo

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Interoceanic Canal Museum or Palacio de las Garzas while you're exploring the area.

Bella Vista

Bella Vista is highly notable for its popular shops, and you might want to visit top sights like Via Espana and Crown Casino. See more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina.

El Cangrejo

The abundant dining options and casinos are top of the list for many visitors to El Cangrejo. A stop by Crown Casino or Luxor Towers might round out your trip.

San Felipe

If you're spending some time in San Felipe, Interoceanic Canal Museum and Palacio de las Garzas are top sights worth seeing.

San Francisco

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

Top Santa Ana Hotel Reviews

Frequently asked questions

What's it like in Santa Ana?
Santa Ana is a neighborhood that travelers like for its seafood restaurants, shopping, and parks. Are you looking for Santa Ana travel tips? Be sure to check out Cinta Costera and Avenida Balboa while you're in the neighborhood.
Where is the best hotel for a stay in Santa Ana?
Expedia customers rank Hostal La Cigarra the highest for a stay in Santa Ana.
How many hotels can I expect to find in Santa Ana?
Expedia has 108 hotels and other accommodations in Santa Ana to choose from, making this an ideal home base for exploring the greater Panama City area.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! Most hotel room reservations are refundable provided that you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you have a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of your booking. Add dates, click "Search", then use the "fully refundable" filter to get top deals in Santa Ana.
Where can I learn more about changing or cancelling my trip to Santa Ana?
To find more details about picking new dates or cancelling your trip to Santa Ana, head over to our customer service page.
What is there to do in this Panama City neighborhood?
If you're looking forward to a day of shopping in Santa Ana, consider Avenida Central or Avenida Balboa, and pick out the perfect souvenir. A visit to Cinta Costera is also worth the trip while you're discovering the neighborhood. Albrook Shopping Mall, Amador Theater, and Museum of Contemporary Art Panama are just a few of the places to visit in and around Santa Ana. When you're sightseeing in Panama City, Mi Pueblito and Iglesia de la Merced are also worth a stop.