Santa Cruz Vacations
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Where to stay in Santa Cruz
Find the best Santa Cruz areas and neighborhoods for the activities you enjoy most. Learn more about Santa Cruz
Historical Center
8 out of top 10 points of interest in this area
Go on an adventure through the ages when you visit the historical churches, palaces, plazas and mansions of Seville’s ancient heart.
El Arenal
Located in Seville's historical center, El Arenal boasts the 13th-century Torre del Oro, Royal Shipyards, and La Real Maestranza bullring. Explore this vibrant area on the Guadalquivir river's east bank.
Alfalfa
Unique features of Alfalfa include the bars and historic sites. Make a stop by Calle Sierpes or Casa de la Memoria Cultural Center while you're exploring the area.
Triana
Discover traditional pottery and vibrant flamenco culture in this lively area. Shop at Triana Market for local crafts and tapas, or explore Calle Betis for popular restaurants, bars, and nightclubs.
San Bartolomé
Travelers come to San Bartolomé for its lively bars, and you can see top attractions like Pilate's House and Zurbarán Statue while you're in town.
Santa Cruz Hotel Deals
Las Casas de la Judería, Sevilla Historic City Center
Calle Santa Maria La Blanca 5 Seville Seville
Fully refundableReserve now, pay when you stay
₩188,375
₩207,212 total
Nov 25 - Nov 26
includes taxes & fees
9.2/10 Wonderful! (1,021 reviews)
"Hot water for taking a bath was good. Swimming pool was cold."
Reviewed on Oct 24, 2026
Hotel Amadeus Sevilla
Calle Farnesio 6 Seville Seville
Fully refundableReserve now, pay when you stay
₩183,976
₩202,369 total
Nov 22 - Nov 23
includes taxes & fees
9.6/10 Exceptional! (1,293 reviews)
"Lovely, charming hotel walking distance to Cathedral and many shops and restaurants along the way."
Reviewed on Oct 25, 2026
Hotel Alfonso XIII, a Luxury Collection Hotel, Seville
San Fernando 2 Seville Seville
Fully refundableReserve now, pay when you stay
₩787,007
₩865,708 total
Nov 23 - Nov 24
includes taxes & fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
How much does a Santa Cruz vacation package cost?
Get ready to book, because a trip to Santa Cruz starts from a tempting . When you combine your hotels, flights and car rentals into a package, you'll enjoy the biggest deals.
How do I get a cheap travel package to Santa Cruz?
Just think of all the fun things you could do in Santa Cruz with a pile of extra cash in your pocket. Watch your savings stack up when you combine your travel bookings into a Santa Cruz vacation package. You have plenty of choice when it comes to booking with Expedia too. In fact, you can select from over 550 airlines and 1,000,000 properties around the world. Whether you're enjoying a break with the whole family or traveling with someone special, exploring Santa Cruz is better with a package.
Where should I stay in Santa Cruz?
Most people who visit Santa Cruz put both Seville Cathedral and Alcázar on their must-see lists. Why not choose a hotel close to one of these iconic attractions?
What are the top hotels in Santa Cruz?
Puerta Catedral Holiday Suites and San Isidoro Hostel Sevilla are among the most well-known properties in Santa Cruz. Why not check out the rates and facilities at each and then make up your mind?
How far in advance should I book my Santa Cruz vacation?
Reserving your seat early with Expedia means one less thing to have to worry about. Most carriers advertise prices up to 12 months prior to take off. This is generally the cheapest time to book. If circumstances have left you booking late, great deals to Santa Cruz sometimes emerge in the weeks leading up to departure.
What does an Expedia Santa Cruz travel package include?
Hotels, car rentals and flights — we bring you the very best deals. All you'll have to do is decide on your ideal combination. Once you've made your booking, you can add on the fun stuff like activities and tours. Our travel packages make it easy to craft an awesome Santa Cruz trip.
What should I know before booking a Santa Cruz travel package?
You'll pick up impressive savings when you bundle your flights, hotels and rental cars into a package. Plus, booking everything in one place just makes things easier. So why waste your time or money? Whether you're putting together an upscale romantic escape or a budget family adventure, explore our vacation packages today.
Can I choose my airline with a Santa Cruz Expedia vacation package?
Yes — that's the beauty of an Expedia package. You're in control. We have more than 550 airline partners around the world, so you have loads of choice when organizing your Santa Cruz getaway.
If I'm not able to travel, can I cancel my Santa Cruz vacation package?
Yes, it's possible to cancel your Santa Cruz booking if your travel plans have changed. Whether you'll be charged a fee or not depends on your airline, hotel or car rental company. You may be able to change or cancel for free if you booked in the last 24 hours. Visit our Customer Service Portal to learn more.
Stay near popular Santa Cruz attractions
Royal Alcázar of Seville
9.6/10 (8,220 reviews)
Discover a millennium’s worth of royal treasures in this architectural masterpiece in the heart of Seville.
Giralda Tower
9.4/10 (6,353 reviews)
Once among the tallest religious monuments in the world, this former minaret is now the eye-catching bell tower to Seville Cathedral.
San Telmo Palace
Tour the striking interior and exterior of a palatial building that serves as the headquarters of the president of the autonomous region of Andalusia.
Triunfo Plaza
9.6/10 (18 reviews)
From this ancient and picturesque square, access some of the oldest and most impressive buildings in Seville, including the world’s largest gothic cathedral.
University of Seville
8.6/10 (1,316 reviews)
Enjoy the collegiate vibe when you visit University of Seville, during your travels in Paseo de Las Delicias. Visit the stunning cathedral and shops in this culturally rich area.
Santa Cruz Church
8.6/10 (26 reviews)
After visiting Santa Cruz Church, make a plan to see the other sights and activities in Seville. Check out the shops and top-notch restaurants in this romantic area.
General Archive of the Indies
8.0/10 (11 reviews)
You can study the exhibits at General Archive of the Indies, a museum with a story of its own, during your travels to Seville. Check out the stunning cathedral and lively bars in this culturally rich area.
Puerta del Príncipe
10.0/10 (2 reviews)
Find out about the history of Seville when you take a trip to Puerta del Príncipe. Check out the stunning cathedral and lively bars in this culturally rich area.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.