Santa Cruz Vacations

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Where to stay in Santa Cruz

Find the best Santa Cruz areas and neighborhoods for the activities you enjoy most. Learn more about Santa Cruz
Historical Center

Historical Center

7 out of top 10 points of interest in this area
4.5/5(606 area reviews)

Go on an adventure through the ages when you visit the historical churches, palaces, plazas and mansions of Seville’s ancient heart.

Find hotels in Historical Center

Santa Cruz Hotel Deals

Hotel Murillo

Hotel Murillo

2 out of 5
Calle Lope de Rueda, 7-9 Seville Seville
Fully refundableReserve now, pay when you stay
The price is ₩102,047 per night from Jun 28 to Jun 29
₩102,047
₩112,252 total
Jun 28 - Jun 29
includes taxes & fees
8.8/10 Excellent! (1,006 reviews)
"La terrasse sur le toit était très charmante. Le petit déjeuner offert est excellent et très varié."

Reviewed on May 27, 2026

Hotel Murillo
Las Casas de la Judería, Sevilla Historic City Center

Las Casas de la Judería, Sevilla Historic City Center

4 out of 5
Calle Santa Maria La Blanca 5 Seville Seville
Fully refundableReserve now, pay when you stay
The price is ₩233,308 per night from Jun 28 to Jun 29
₩233,308
₩256,639 total
Jun 28 - Jun 29
includes taxes & fees
9.2/10 Wonderful! (1,001 reviews)
"The staff were extremely helpful and the breakfast offered a wide variety of breakfast foods to select from."

Reviewed on May 30, 2026

Las Casas de la Judería, Sevilla Historic City Center
Hotel Amadeus Sevilla

Hotel Amadeus Sevilla

4 out of 5
Calle Farnesio 6 Seville Seville
Fully refundableReserve now, pay when you stay
The price is ₩231,762 per night from Jun 30 to Jul 1
₩231,762
₩254,939 total
Jun 30 - Jul 1
includes taxes & fees
9.6/10 Exceptional! (1,220 reviews)
"Nice stay in the heart of the city. Old building transformed with Musical decor. Very attentive staff. Nice breakfast. Clean and comfortable. We did not drive. That could be a challenge, but I did see a parking garage next door. Not sure if affiliated"

Reviewed on May 30, 2026

Hotel Amadeus Sevilla
See all 431 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Santa Cruz vacation package cost?
Get ready to book, because a trip to Santa Cruz starts from a tempting . When you combine your hotels, flights and car rentals into a package, you'll enjoy the biggest deals.
How do I get a cheap travel package to Santa Cruz?
Just think of all the fun things you could do in Santa Cruz with a pile of extra cash in your pocket. Watch your savings stack up when you combine your travel bookings into a Santa Cruz vacation package. You have plenty of choice when it comes to booking with Expedia too. In fact, you can select from over 550 airlines and 1,000,000 properties around the world. Whether you're enjoying a break with the whole family or traveling with someone special, exploring Santa Cruz is better with a package.
Where should I stay in Santa Cruz?
Most people who visit Santa Cruz put both Seville Cathedral and Alcázar on their must-see lists. Why not choose a hotel close to one of these iconic attractions?
What are the top hotels in Santa Cruz?
Puerta Catedral Holiday Suites and San Isidoro Hostel Sevilla are among the most well-known properties in Santa Cruz. Why not check out the rates and facilities at each and then make up your mind?
How far in advance should I book my Santa Cruz vacation?
Reserving your seat early with Expedia means one less thing to have to worry about. Most carriers advertise prices up to 12 months prior to take off. This is generally the cheapest time to book. If circumstances have left you booking late, great deals to Santa Cruz sometimes emerge in the weeks leading up to departure.
What does an Expedia Santa Cruz travel package include?
Hotels, car rentals and flights — we bring you the very best deals. All you'll have to do is decide on your ideal combination. Once you've made your booking, you can add on the fun stuff like activities and tours. Our travel packages make it easy to craft an awesome Santa Cruz trip.
What should I know before booking a Santa Cruz travel package?
You'll pick up impressive savings when you bundle your flights, hotels and rental cars into a package. Plus, booking everything in one place just makes things easier. So why waste your time or money? Whether you're putting together an upscale romantic escape or a budget family adventure, explore our vacation packages today.
Can I choose my airline with a Santa Cruz Expedia vacation package?
Yes — that's the beauty of an Expedia package. You're in control. We have more than 550 airline partners around the world, so you have loads of choice when organizing your Santa Cruz getaway.
If I'm not able to travel, can I cancel my Santa Cruz vacation package?
Yes, it's possible to cancel your Santa Cruz booking if your travel plans have changed. Whether you'll be charged a fee or not depends on your airline, hotel or car rental company. You may be able to change or cancel for free if you booked in the last 24 hours. Visit our Customer Service Portal to learn more.

Discover the most popular places to visit in Santa Cruz

Royal Alcázar of Seville

Royal Alcázar of Seville

5/5(747 reviews)

Discover a millennium’s worth of royal treasures in this architectural masterpiece in the heart of Seville.

Royal Alcázar of Seville
Giralda Tower

Giralda Tower

4.5/5(500 reviews)

Once among the tallest religious monuments in the world, this former minaret is now the eye-catching bell tower to Seville Cathedral.

Giralda Tower
San Telmo Palace

San Telmo Palace

Tour the striking interior and exterior of a palatial building that serves as the headquarters of the president of the autonomous region of Andalusia.

San Telmo Palace
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.