Photo by Hazem Abdul

Find hotels in South Main, Houston from ₩104,360

Most hotels are fully refundable. Because flexibility matters.

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Discover 6,355 South Main hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

The Lancaster Hotel
Exterior
The Lancaster Hotel
4.0 star property
9.8 out of 10, Exceptional, (1524)
"Beautiful hotel and excellent service!"
The price is ₩329,445
per night
May 23 - May 24
The Lancaster Hotel
The Post Oak Hotel at Uptown Houston
Outdoor pool, cabanas (surcharge), pool umbrellas
The Post Oak Hotel at Uptown Houston
5.0 star property
9.6 out of 10, Exceptional, (608)
"Safe"
The price is ₩766,248
per night
Jun 10 - Jun 11
The Post Oak Hotel at Uptown Houston
InterContinental Houston, an IHG Hotel
International cuisine
InterContinental Houston, an IHG Hotel
4.0 star property
9.4 out of 10, Exceptional, (1000)
"Very professional and polite staff. Room was very clean and updated. Very pleased with stay at this hotel. Will book there again! "
The price is ₩219,938
per night
Jun 14 - Jun 15
InterContinental Houston, an IHG Hotel
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Blossom Hotel Houston
City view
Blossom Hotel Houston
4.0 star property
9.2 out of 10, Wonderful, (2120)
"Friendly staff, bomb breakfast, luxe and safe environment "
The price is ₩261,831
per night
May 31 - Jun 1
Blossom Hotel Houston
Hilton Americas-Houston
Exterior
Hilton Americas-Houston
4.0 star property
9.2 out of 10, Wonderful, (1074)
"Like the property is well maintained, the room is spacious and so clean."
The price is ₩243,212
per night
May 26 - May 27
Hilton Americas-Houston
JW Marriott Houston Downtown
Exterior
JW Marriott Houston Downtown
5.0 star property
9.2 out of 10, Wonderful, (1000)
"Excellent location particularly for Astros fans in town!"
The price is ₩347,944
per night
May 31 - Jun 1
JW Marriott Houston Downtown
Hyatt Place Houston Downtown
Lobby sitting area
Hyatt Place Houston Downtown
3.0 star property
9.0 out of 10, Wonderful, (1286)
"Staff made us feel very comfortable and safe. "
The price is ₩180,715
per night
May 19 - May 20
Hyatt Place Houston Downtown
Hyatt Regency Houston
City view
Hyatt Regency Houston
4.0 star property
9.0 out of 10, Wonderful, (1570)
"My stay was amazing !!! "
The price is ₩217,679
per night
May 26 - May 27
Hyatt Regency Houston
Hyatt Place Houston Medical Center
Lobby
Hyatt Place Houston Medical Center
3.0 star property
9.0 out of 10, Wonderful, (641)
"Everything was fine but the parking garage is confusing, you need arrows on the ground "
The price is ₩171,268
per night
May 26 - May 27
Hyatt Place Houston Medical Center
Cambria Hotel Houston Downtown Convention Center
Lobby
Cambria Hotel Houston Downtown Convention Center
3.0 star property
8.8 out of 10, Excellent, (1316)
"I didn't like the construction equipment all in front of the building when there was no construction present. I love the hotel character, staff friendliness, very modern and clean room. The hotel was in a convenient location to all the restaurants downtown walking distance "
The price is ₩163,758
per night
May 22 - May 23
Cambria Hotel Houston Downtown Convention Center
Hotel Zaza Houston Museum District
Daily cooked-to-order breakfast for a fee
Hotel Zaza Houston Museum District
4.5 star property
8.8 out of 10, Excellent, (1367)
"Amazing getaway!!❤️"
The price is ₩368,274
per night
May 16 - May 17
Hotel Zaza Houston Museum District
AC Hotel by Marriott Houston Downtown
View from room
AC Hotel by Marriott Houston Downtown
3.5 star property
8.8 out of 10, Excellent, (727)
"My experience at the hotel was great."
The price is ₩165,107
per night
May 27 - May 28
AC Hotel by Marriott Houston Downtown
Marriott Marquis Houston
2 outdoor pools, open 6:00 AM to 10:00 PM, cabanas (surcharge)
Marriott Marquis Houston
4.0 star property
8.6 out of 10, Excellent, (1005)
"Besides me thinking i got the corner view with the pool but ended up facing the George R Brown center everything was good. Staff was extremely nice and place was very clean even the pool area. "
The price is ₩368,274
per night
May 27 - May 28
Marriott Marquis Houston
Courtyard by Marriott Houston Medical Center/NRG Park
Outdoor pool, pool umbrellas
Courtyard by Marriott Houston Medical Center/NRG Park
3.0 star property
8.6 out of 10, Excellent, (1003)
"Random charges throughout the night for unknown reasons "
The price is ₩138,479
per night
May 24 - May 25
Courtyard by Marriott Houston Medical Center/NRG Park
Hotel Ylem
Free daily continental breakfast
Hotel Ylem
3.5 star property
8.6 out of 10, Excellent, (1644)
"Near a Kroger Walgreens restaurants at walking distance and near by parks to take kids if you have any. It was excellent 👍 no construction while we were there April 28. Front staff was accommodating and hears one out! Breakfast space was very decorated and food was an okay variety. Will come back again when in Houston "
The price is ₩104,360
per night
May 27 - May 28
Hotel Ylem
HYATT house Houston/Galleria
Outdoor pool
HYATT house Houston/Galleria
3.0 star property
8.4 out of 10, Very Good, (2105)
"Staff was very good. Front desk manager Tiger helped me with the change of room. Hotel was nice, rooms are good & clean. Breakfast is good. "
The price is ₩155,415
per night
May 21 - May 22
HYATT house Houston/Galleria
Hyatt Regency Houston/Galleria
Outdoor pool, open 6:00 AM to 10:00 PM, pool umbrellas, sun loungers
Hyatt Regency Houston/Galleria
4.0 star property
8.4 out of 10, Very Good, (1434)
"Stayed for three days and we enjoyed ourselves. Clean, quiet and nice hotel. Will definitely stay there again when in town. "
The price is ₩197,094
per night
Jun 2 - Jun 3
Hyatt Regency Houston/Galleria
Holiday Inn Houston Downtown, an IHG Hotel
Property amenity
Holiday Inn Houston Downtown, an IHG Hotel
3.0 star property
8.4 out of 10, Very Good, (1000)
"The gentleman man and valet guy was very nice!!!"
The price is ₩141,893
per night
May 26 - May 27
Holiday Inn Houston Downtown, an IHG Hotel
Courtyard by Marriott Houston Downtown/Convention Center
Exterior
Courtyard by Marriott Houston Downtown/Convention Center
3.0 star property
8.4 out of 10, Very Good, (1001)
"Staff is exceptional. Wonderful people. "
The price is ₩138,404
per night
May 27 - May 28
Courtyard by Marriott Houston Downtown/Convention Center
Springhill Suites by Marriott Houston Dwntn/Convention Cntr
Exterior
Springhill Suites by Marriott Houston Dwntn/Convention Cntr
2.5 star property
8.4 out of 10, Very Good, (999)
"Just had a girls night with my sister and our friend. We swam and drank and ordered pizza. The pool was very nice. I had a great time. "
The price is ₩150,116
per night
May 30 - May 31
Springhill Suites by Marriott Houston Dwntn/Convention Cntr
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4.5/5(2,300 area reviews)

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South Main hotels information

Number of reviews
26,851
Accommodation
6,355 hotels
Lowest Price
₩104,360
Highest Price
₩766,248

Frequently asked questions

What is South Main like?

You'll be sure to have fun visiting Houston's South Main neighborhood. Consider a visit to NRG Park as part of your South Main travel plans.

Where is the best hotel for a stay in South Main?

Based on Expedia customer reviews, Comfort Suites near Texas Medical Center - NRG Stadium is the highest ranked property in South Main. This hotel is a short 9-minute walk from NRG Stadium, and it offers free breakfast and free parking. Other top choices in the neighborhood include Candlewood Suites Houston Medical Center, an IHG Hotel and Wyndham Houston near NRG Park/Medical Center.

How many hotels will I be able to find in South Main?

If you're searching for places to stay in Houston, Expedia has something to meet your needs with 90 South Main hotels and other accommodations to choose from.

If I need to cancel my hotel reservation in South Main, will I receive a refund?

Yes, the majority of hotel bookings are refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then use the filter option "fully refundable" to get the best options available in South Main.

Where can I learn more about changing or cancelling my trip to South Main?

For more details about changing or cancelling your trip to South Main, head over to our customer service page.

What can I see and do in this Houston neighborhood?

NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, be sure to visit other sights like NRG Stadium or NRG Arena.

How can I get around South Main and the greater Houston area?

Ready to get out and explore the city? Fannin South Station is the closest metro station.

Recent reviews of South Main hotels

The Whitehall Houston

The Whitehall Houston

5/5 Excellent
"Sothernly" hospitality and charm
"I had a great one-night stay at the Whitehall. The room was well-appointed and very comfortable. The hotel is run by Sotherly and they had some nice touches - lemon cookies in the room, a veteran-focused foundation that they make you aware of, etc. The 1st floor bar, with an outside space, looked awesome. I just didn't have time to visit. The location is fine - a little on the outer edge of that side of downtown. I was close to my venue, so it was perfect for me. The only thing to note is that one side of the hotel is facing the highway. If you are sensitive to outdoor noises, you'll want to request a room that is not on that side. I sleep pretty hard, so didn't notice it until I woke up."
A verified traveler stayed at The Whitehall Houston
Posted 1 day ago
The Whitehall Houston