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Our top choices for South Main hotels

Wyndham Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center
3.5 star property
South Main
7.0 out of 10, Good, (1,289 reviews)
"Hotel clean and convenient "
United States
Mitzi
The price is ₩133,487
₩156,179 total
includes taxes & fees
Apr 26 - Apr 27
Wyndham Houston near NRG Park/Medical Center

Wingate Houston near NRG Park/Medical Center

Wingate Houston near NRG Park/Medical Center
3.0 star property
South Main
6.6 out of 10, (1,016 reviews)
"Great location"
United States
Jeremy
The price is ₩117,172
₩137,092 total
includes taxes & fees
Apr 19 - Apr 20
Wingate Houston near NRG Park/Medical Center

Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
South Main
8.6 out of 10, Excellent, (1,014 reviews)
"Great location if you’re headed to NRG, room was very clean. Good for an overnight "
United States
Daisy
The price is ₩133,858
₩156,614 total
includes taxes & fees
Apr 19 - Apr 20
Comfort Suites Houston near Medical Center- NRG Stadium

Candlewood Suites Houston Medical Center by IHG

Candlewood Suites Houston Medical Center by IHG
2.5 star property
South Main
7.4 out of 10, Good, (850 reviews)
"Room was clean. It had a musty smell though. "
United States
Ryan
The price is ₩115,689
₩135,356 total
includes taxes & fees
Apr 20 - Apr 21
Candlewood Suites Houston Medical Center by IHG

Quality Inn & Suites NRG Park - Medical Center

Quality Inn & Suites NRG Park - Medical Center
2.5 star property
South Main
6.6 out of 10, (1,006 reviews)
"Courteous staff, clean room, quite property"
United States
Javier
The price is ₩93,515
₩109,412 total
includes taxes & fees
Apr 26 - Apr 27
Quality Inn & Suites NRG Park - Medical Center

Crystal Inn Northeast Houston Downtown I-610

Crystal Inn Northeast Houston Downtown I-610
2.5 star property
Northside, 18.9 km from South Main
8.2 out of 10, Very Good, (142 reviews)
"This motel was very clean and well maintained. The staff were very kind"
United States
Suzette
The price is ₩90,090
₩105,404 total
includes taxes & fees
Apr 26 - Apr 27
Crystal Inn Northeast Houston Downtown I-610

Palace Inn Blue Edgebrook

Palace Inn Blue Edgebrook
3.0 star property
16.8 km from South Main
9.4 out of 10, Exceptional, (165 reviews)
"This was a great location from downtown. The price was fair, and the rooms were spacious and clean. Great customer service!"
United States
Tarevea
The price is ₩162,187
₩195,450 total
includes taxes & fees
Apr 13 - Apr 14
Palace Inn Blue Edgebrook

Hotel Royale

Hotel Royale
2.0 star property
20.9 km from South Main
9.2 out of 10, Wonderful, (24 reviews)
"Room was very clean and convenient for my short stay. Would recommend for business trips. "
United States
Jerome
The price is ₩120,138
₩140,561 total
includes taxes & fees
Apr 13 - Apr 14
Hotel Royale

Best Western Plus Pearland/Houston Medical Center Hotel

Best Western Plus Pearland/Houston Medical Center Hotel
2.5 star property
Southeast Houston, 10.2 km from South Main
9.4 out of 10, Exceptional, (213 reviews)
"I always go to this hotel after comparing my stay at other hotels. This hotel is perfect for solo travelers and families."
United States
Regina
The price is ₩132,167
₩154,636 total
includes taxes & fees
May 7 - May 8
Best Western Plus Pearland/Houston Medical Center Hotel

Crystal Inn - NorthWest - 290

Crystal Inn - NorthWest - 290
2.0 star property
24.8 km from South Main
9.8 out of 10, Exceptional, (48 reviews)
"The best hotel I’ve been in excellent rooms perfect customer service rooms are phenomenal"
United States
Michael
The price is ₩147,993
₩170,191 total
includes taxes & fees
Apr 13 - Apr 14
Crystal Inn - NorthWest - 290

Home2 Suites by Hilton Houston Pasadena

Home2 Suites by Hilton Houston Pasadena
3.0 star property
24.3 km from South Main
9.4 out of 10, Exceptional, (858 reviews)
"Breakfast offerings were limited, but overall, the stay was great. Beds were comfortable, room was clean, staff was friendly. Felt safe in our hotel and would gladly stay again."
United States
Travis
The price is ₩114,206
₩133,622 total
includes taxes & fees
Apr 25 - Apr 26
Home2 Suites by Hilton Houston Pasadena

Palace Inn Blue 290 W 43rd & Bingle Rd

Palace Inn Blue 290 W 43rd & Bingle Rd
2.5 star property
19.4 km from South Main
9.6 out of 10, Exceptional, (32 reviews)
"loveeeee. so cute came here for spring break. comfy little spot definitely recommend!"
United States
Danielle
The price is ₩132,004
₩154,444 total
includes taxes & fees
Apr 19 - Apr 20
Palace Inn Blue 290 W 43rd & Bingle Rd

Tru by Hilton Houston Webster NASA

Tru by Hilton Houston Webster NASA
2.5 star property
30.7 km from South Main
9.0 out of 10, Wonderful, (1,003 reviews)
"Clean and courteous staff."
United States
chris
The price is ₩126,516
₩148,022 total
includes taxes & fees
May 10 - May 11
Tru by Hilton Houston Webster NASA

Hampton Inn & Suites Houston-Bush Intercontinental Aprt

Hampton Inn & Suites Houston-Bush Intercontinental Aprt
3.0 star property
31.8 km from South Main
8.8 out of 10, Excellent, (1,837 reviews)
"Very comfortable stay. Staff was very friendly, great location, 1 mile away from the airport car rental return, places to eat in walking distance next door to gas station. The room was nice for a 1 or 2 night stay."
United States
Tanasha
The price is ₩161,193
₩189,595 total
includes taxes & fees
May 8 - May 9
Hampton Inn & Suites Houston-Bush Intercontinental Aprt

Courtyard by Marriott Houston Intercontinental Airport

Courtyard by Marriott Houston Intercontinental Airport
3.0 star property
31.8 km from South Main
9.0 out of 10, Wonderful, (1,200 reviews)
"Super clean and close to the AirPort "
United States
Keiry
The price is ₩187,846
₩219,780 total
includes taxes & fees
May 9 - May 10
Courtyard by Marriott Houston Intercontinental Airport

La Quinta Inn & Suites by Wyndham Houston Bush IAH South

La Quinta Inn & Suites by Wyndham Houston Bush IAH South
3.0 star property
31.2 km from South Main
8.2 out of 10, Very Good, (1,804 reviews)
"The rooms were clean and it was very beautiful hotel "
United States
Kaneiya
The price is ₩137,492
₩160,865 total
includes taxes & fees
May 4 - May 5
La Quinta Inn & Suites by Wyndham Houston Bush IAH South

Best Western Plus Manvel Inn & Suites

Best Western Plus Manvel Inn & Suites
2.5 star property
22.6 km from South Main
8.8 out of 10, Excellent, (774 reviews)
"This location has a gym, hot tub, and pool. The staff are all very courteous and helpful. The room was exceptionally clean and comfortable. I will definitely visit this location again."
United States
David
The price is ₩118,492
₩133,896 total
includes taxes & fees
Apr 27 - Apr 28
Best Western Plus Manvel Inn & Suites

Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham

Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham
3.0 star property
18.5 km from South Main
8.8 out of 10, Excellent, (1,142 reviews)
"Great breakfast and staff was wonderful."
United States
Jeffery
The price is ₩124,810
₩143,528 total
includes taxes & fees
Apr 13 - Apr 14
Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham

SpringHill Suites by Marriott Houston Intercontinental Arprt

SpringHill Suites by Marriott Houston Intercontinental Arprt
3.0 star property
31.8 km from South Main
9.0 out of 10, Wonderful, (1,717 reviews)
"Perfect hotel if need to stay close to the airport. Great service and amenities, very nice and spacious rooms."
Canada
Ashraf
The price is ₩183,916
₩215,180 total
includes taxes & fees
Apr 25 - Apr 26
SpringHill Suites by Marriott Houston Intercontinental Arprt

Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center
4.5 star property
Texas Medical Center, 4.4 km from South Main
8.4 out of 10, Very Good, (1,879 reviews)
"Very clean property, staff was helpful"
United States
Elton
The price is ₩191,332
₩225,580 total
includes taxes & fees
Apr 19 - Apr 20
Hilton Houston Plaza/Medical Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Compare popular hotels in South Main

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
Individually decorated, individually furnished, desk, laptop workspace
Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
8.6
Excellent
1,014 reviews
View
Exterior
Candlewood Suites Houston Medical Center by IHG
2.5 star property
7.4
Good
850 reviews
View
Premium bedding, pillowtop beds, in-room safe, individually decorated
Wyndham Houston near NRG Park/Medical Center
3.5 star property
7.0
Good
1,289 reviews
View
Lobby
Wingate Houston near NRG Park/Medical Center
3.0 star property
6.6
1,016 reviews
View
Hypo-allergenic bedding, in-room safe, individually decorated
Quality Inn & Suites NRG Park - Medical Center
2.5 star property
6.6
1,006 reviews
View

Where to stay in South Main

Find the best South Main areas and neighborhoods for the activities you enjoy most.

Downtown Houston

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

The Galleria

Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.

Texas Medical Center

Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.

Montrose

Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.

Top South Main Hotel Reviews

Frequently asked questions

What is South Main like?
You'll be sure to have fun visiting Houston's South Main neighborhood. Consider a visit to NRG Park as part of your South Main travel plans.
Where is the best hotel for a stay in South Main?
Based on our traveler data, Wyndham Houston near NRG Park/Medical Center is one of the top choices for your stay in South Main. This hotel is a short 9-minute walk from NRG Stadium, and it offers a restaurant and an outdoor pool.
How many hotels will I be able to find in South Main?
If you're searching for places to stay in Houston, Expedia has something to meet your needs with 65 South Main hotels and other accommodations to choose from.
If I need to cancel my hotel reservation in South Main, will I receive a refund?
Yes, the majority of hotel bookings are refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then use the filter option "fully refundable" to get the best options available in South Main.
Where can I learn more about changing or cancelling my trip to South Main?
For more details about changing or cancelling your trip to South Main, head over to our customer service page.
What can I see and do in this Houston neighborhood?
NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, be sure to visit other sights like NRG Stadium or NRG Arena.
How can I get around South Main and the greater Houston area?
Ready to get out and explore the city? Fannin South Station is the closest metro station.