Find hotels in South Main, Houston
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Our top choices for South Main hotels
1. Wyndham Houston at Reliant Park & Medical Center
Wyndham Houston at Reliant Park & Medical CenterSouth Main
7.2 out of 10, Good, (1,395 reviews)
"Nice stay"
Timothy
The price is ₩129,445
₩151,449 total
includes taxes & fees
Sep 7 - Sep 8
2. Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHGSouth Main
7.4 out of 10, Good, (896 reviews)
"Great amenities!"
Michelle
The price is ₩114,236
₩133,656 total
includes taxes & fees
Sep 14 - Sep 15
3. Comfort Suites Houston near Medical Center- NRG Stadium
Comfort Suites Houston near Medical Center- NRG StadiumSouth Main
8.8 out of 10, Excellent, (1,000 reviews)
"The room was very clean.The breakfast was really good.The staff was nice and the parking good !"
Linda
The price is ₩133,560
₩156,266 total
includes taxes & fees
Sep 8 - Sep 9
4. Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical CenterSouth Main
6.6 out of 10, (1,001 reviews)
"Regular aceptable ."
Oscar
The price is ₩95,325
₩111,530 total
includes taxes & fees
Sep 14 - Sep 15
5. Wingate Houston at Reliant Park & Medical Center
Wingate Houston at Reliant Park & Medical CenterSouth Main
6.6 out of 10, (1,000 reviews)
"My overall stay was good and property was well maintained and cleaned and staff was super helpful"
Terry
The price is ₩126,623
₩148,150 total
includes taxes & fees
Aug 30 - Aug 31
6. Hyatt Place Houston Medical Center
Hyatt Place Houston Medical CenterTexas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (2,625 reviews)
"Great stay"
Michael
The price is ₩172,180
₩202,517 total
includes taxes & fees
Sep 6 - Sep 7
7. Hotel Ylem
Hotel Ylem2.3 km from South Main
8.4 out of 10, Very Good, (1,562 reviews)
"Great staff and room"
Meryem
The price is ₩109,684
₩135,212 total
includes taxes & fees
Sep 5 - Sep 6
8. Courtyard By Marriott Houston Medical Center Reliant Park
Courtyard By Marriott Houston Medical Center Reliant Park2.7 km from South Main
8.6 out of 10, Excellent, (1,001 reviews)
"Great Hotel!"
Jorge
The price is ₩145,066
₩171,489 total
includes taxes & fees
Sep 5 - Sep 6
9. Blossom Hotel Houston, Curio Collection by Hilton
Blossom Hotel Houston, Curio Collection by HiltonTexas Medical Center, 3.5 km from South Main
9.0 out of 10, Wonderful, (3,884 reviews)
"Perfect location, excellent rooms and free car service to MDA appts."
Isabel
The price is ₩192,658
₩225,410 total
includes taxes & fees
Sep 6 - Sep 7
10. Hyatt House Houston Medical Center
Hyatt House Houston Medical CenterTexas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (1,277 reviews)
"Very reliable hotel"
Leland
The price is ₩173,877
₩204,517 total
includes taxes & fees
Sep 5 - Sep 6
11. The Westin Houston Medical Center/Museum District
The Westin Houston Medical Center/Museum DistrictTexas Medical Center, 4.4 km from South Main
9.2 out of 10, Wonderful, (1,187 reviews)
"Loved the location and hospitality of the staff. Enjoyed the restaurant in the hotel."
Stanley
The price is ₩188,407
₩234,512 total
includes taxes & fees
Sep 7 - Sep 8
12. Hilton Houston Plaza/Medical Center
Hilton Houston Plaza/Medical CenterTexas Medical Center, 4.4 km from South Main
8.4 out of 10, Very Good, (2,122 reviews)
"Our stay was great"
Cindy
The price is ₩110,603
₩131,002 total
includes taxes & fees
Sep 6 - Sep 7
13. Crowne Plaza Houston Med Ctr-Galleria Area by IHG
Crowne Plaza Houston Med Ctr-Galleria Area by IHGGreenway Plaza-Upper Kirby, 6.5 km from South Main
7.8 out of 10, Good, (1,608 reviews)
"Stay was nice’! Will stay again"
Lanita
The price is ₩92,215
₩107,892 total
includes taxes & fees
Sep 8 - Sep 9
14. Homewood Suites by Hilton Houston Memorial
Homewood Suites by Hilton Houston Memorial16.4 km from South Main
9.6 out of 10, Exceptional, (1,002 reviews)
"Excellent property, rooms, staff, breakfast, location, etc......."
Roland
The price is ₩123,017
₩143,930 total
includes taxes & fees
Sep 6 - Sep 7
15. Drury Inn & Suites Houston Near the Galleria
Drury Inn & Suites Houston Near the GalleriaThe Galleria, 9.4 km from South Main
9.4 out of 10, Exceptional, (1,540 reviews)
"Great location, wonderful breakfast"
Andrei
The price is ₩129,362
₩151,353 total
includes taxes & fees
Sep 6 - Sep 7
16. Hyatt Regency Houston West
Hyatt Regency Houston West23.2 km from South Main
8.6 out of 10, Excellent, (1,603 reviews)
"Nice stay"
Tami
The price is ₩112,970
₩132,170 total
includes taxes & fees
Aug 30 - Aug 31
17. DoubleTree by Hilton Hotel Houston - Greenway Plaza
DoubleTree by Hilton Hotel Houston - Greenway PlazaGreenway Plaza-Upper Kirby, 6.6 km from South Main
8.4 out of 10, Very Good, (1,841 reviews)
"Great stay"
Raphael
The price is ₩122,494
₩143,318 total
includes taxes & fees
Aug 30 - Aug 31
18. Sonesta ES Suites Houston Galleria
Sonesta ES Suites Houston GalleriaThe Galleria, 8.4 km from South Main
8.4 out of 10, Very Good, (1,375 reviews)
"Clean room, helpful staff, and excellent breakfast."
Mikhail
The price is ₩145,790
₩170,570 total
includes taxes & fees
Sep 12 - Sep 13
19. The Chifley Houston, Tapestry Collection by Hilton
The Chifley Houston, Tapestry Collection by HiltonThe Galleria, 8.7 km from South Main
9.2 out of 10, Wonderful, (1,337 reviews)
"Overall great hotel in a convenient location"
Emily
The price is ₩145,589
₩170,339 total
includes taxes & fees
Sep 5 - Sep 6
20. Hyatt Place Houston/Galleria
Hyatt Place Houston/Galleria8.7 km from South Main
8.8 out of 10, Excellent, (1,599 reviews)
"I always stay at this hotel. Comfortable beds and breakfast is great!"
Natasha
The price is ₩148,645
₩174,822 total
includes taxes & fees
Sep 1 - Sep 2
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Compare popular hotels in South Main
Property | Property class | Guest rating | Breakfast included | Pool | Spa | Pet friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
 Comfort Suites Houston near Medical Center- NRG Stadium | 8.8 Excellent 1,000 reviews | View | ||||||
 Wyndham Houston at Reliant Park & Medical Center | 7.2 Good 1,395 reviews | View | ||||||
 Candlewood Suites Houston Medical Center by IHG | 7.4 Good 896 reviews | View | ||||||
 Quality Inn & Suites NRG Park - Medical Center | 6.6 1,001 reviews | View | ||||||
 Wingate Houston at Reliant Park & Medical Center | 6.6 1,000 reviews | View |
Where to stay in South Main
Find the best South Main areas and neighborhoods for the activities you enjoy most.
Downtown Houston
Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.
The Galleria
Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.
Texas Medical Center
Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.
Montrose
Unique features of Montrose include the theaters and museums. Make a stop by Menil Collection or The Chapel of St. Basil while you're exploring the area.
Photo by George Zimzores
Open Photo by George Zimzores
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.
Top South Main Hotel Reviews
La Quinta Inn & Suites by Wyndham Houston Bush IAH South
10/10 Excellent
