What is South Main like?

You'll be sure to have fun visiting Houston's South Main neighborhood. Consider a visit to NRG Park as part of your South Main travel plans.

Where is the best hotel for a stay in South Main?

Based on Expedia customer reviews, Comfort Suites Houston near Medical Center- NRG Stadium is the highest ranked property in South Main. This hotel is a short 10-minute walk from NRG Stadium, and it offers free breakfast and a fitness center. Other top choices in the neighborhood include Candlewood Suites Houston Medical Center by IHG and Quality Inn & Suites NRG Park - Medical Center .

How many hotels will I be able to find in South Main?

If you're searching for places to stay in Houston, Expedia has something to meet your needs with 64 South Main hotels and other accommodations to choose from.

If I need to cancel my hotel reservation in South Main, will I receive a refund?

Yes, the majority of hotel bookings are refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then use the filter option "fully refundable" to get the best options available in South Main.

Where can I learn more about changing or cancelling my trip to South Main?

For more details about changing or cancelling your trip to South Main, head over to our customer service page .

What can I see and do in this Houston neighborhood?

NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, be sure to visit other sights like NRG Stadium or NRG Arena.

How can I get around South Main and the greater Houston area?

Ready to get out and explore the city? Fannin South Station is the closest metro station.

Top South Main Hotels

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Our top choices for South Main hotels

Individually decorated, individually furnished, desk, laptop workspace

Comfort Suites Houston near Medical Center- NRG Stadium

South Main

George

₩174,157 total

includes taxes & fees

Feb 8 - Feb 9

Premium bedding, pillowtop beds, in-room safe, individually decorated

Wyndham Houston near NRG Park/Medical Center

South Main

MARINA

₩169,662 total

includes taxes & fees

Feb 7 - Feb 8

Wingate Houston near NRG Park/Medical Center

South Main

Richard

₩139,121 total

includes taxes & fees

Feb 9 - Feb 10

Hypo-allergenic bedding, in-room safe, individually decorated

Quality Inn & Suites NRG Park - Medical Center

South Main

Daniel

₩109,941 total

includes taxes & fees

Feb 18 - Feb 19

Candlewood Suites Houston Medical Center by IHG

South Main

Myra

₩125,549 total

includes taxes & fees

Feb 7 - Feb 8

The Chifley Houston, Tapestry Collection by Hilton

The Galleria, 8.7 km from South Main

PHIL

₩216,963 total

includes taxes & fees

Feb 7 - Feb 8

Tru by Hilton Houston Webster NASA

30.7 km from South Main

Kathy

₩137,731 total

includes taxes & fees

Feb 12 - Feb 13

Magnolia Hotel Houston, A Tribute Portfolio Hotel

Houston Central Business District, 11 km from South Main

Matthew

₩264,545 total

includes taxes & fees

Feb 6 - Feb 7

Hyatt Place Houston Medical Center

Texas Medical Center, 3.1 km from South Main

John

₩198,022 total

includes taxes & fees

Feb 8 - Feb 9

The Whitehall Houston

Houston Central Business District, 10 km from South Main

Yitsy

₩244,460 total

includes taxes & fees

Feb 22 - Feb 23

Holiday Inn Express & Suites Houston - Memorial City Centre by IHG

18.4 km from South Main

Amarachi

₩183,746 total

includes taxes & fees

Feb 15 - Feb 16

Outdoor pool, open 6:00 AM to 10:00 PM, pool umbrellas, sun loungers

Hyatt Regency Houston/Galleria

8.7 km from South Main

Kim

₩261,538 total

includes taxes & fees

Feb 20 - Feb 21

Outdoor pool, free cabanas, pool umbrellas

The Westin Houston Medical Center/Museum District

Texas Medical Center, 4.4 km from South Main

Travis

₩262,948 total

includes taxes & fees

Feb 15 - Feb 16

Holiday Inn Houston Downtown by IHG

Houston Central Business District, 10 km from South Main

Meagan

₩214,155 total

includes taxes & fees

Feb 12 - Feb 13

Platinum Inn & Suites Webster

30.8 km from South Main

Ammon

₩113,928 total

includes taxes & fees

Feb 18 - Feb 19

Blossom Hotel Houston, Curio Collection by Hilton

Texas Medical Center, 3.5 km from South Main

Jamee

₩295,007 total

includes taxes & fees

Feb 8 - Feb 9

Home2 Suites by Hilton at the Galleria

Greater Uptown, 8 km from South Main

Firas

₩169,804 total

includes taxes & fees

Feb 12 - Feb 13

Hampton Inn Houston-Near The Galleria

The Galleria, 9.1 km from South Main

Cindie

₩171,076 total

includes taxes & fees

Feb 15 - Feb 16

Suite, 1 Bedroom | In-room safe, desk, blackout drapes, iron/ironing board

Hyatt Place Houston/Galleria

8.7 km from South Main

Barbara

₩206,247 total

includes taxes & fees

Feb 7 - Feb 8

Drury Inn & Suites Houston Near the Galleria

The Galleria, 9.4 km from South Main

wanda

₩160,677 total

includes taxes & fees

Feb 22 - Feb 23

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Where to stay in South Main

Find the best South Main areas and neighborhoods for the activities you enjoy most.

Discovery Green showing a high rise building, a garden and street scenes

Downtown Houston

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

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The Galleria

Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.

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Houston_TexasChildrensHospital_553248635389801905_9

Texas Medical Center

Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.

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Taken in front of apartments.

#UrbanJungle

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.

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Menil Collection which includes interior views

Montrose

Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

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Top South Main Hotel Reviews

Blossom Hotel Houston, Curio Collection by Hilton

10/10 Excellent

"I had a great stay overall, and the hotel was very nice and clean. However, there was a lack of urgency when it came to meeting certain requests. I had to call multiple times for extra towels, and no one came, so I eventually had to step into the hallway to ask housekeeping directly. Aside from that, I would definitely consider staying here again."