South Main Vacations
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Where to stay in South Main
Find the best South Main areas and neighborhoods for the activities you enjoy most. Learn more about South Main
Downtown Memphis
4 out of top 10 points of interest in this area
Home to the Memphis Redbirds and Grizzlies NBA team, this central business district offers entertainment, dining, and attractions like Beale Street, FedExForum, and AutoZone Park. Easily accessible via major highways and public transit options.
East Memphis
2 out of top 10 points of interest in this area
East Memphis is beloved for its popular shops. Take some time to explore sights in the area like Theatre Memphis and Memphis Botanic Garden.
Midtown
1 out of top 10 points of interest in this area
Immerse yourself in the arts scene with institutions like Playhouse on the Square and Brooks Museum of Art, or explore Overton Park's Memphis Zoo. Enjoy live music at Cooper-Young's vibrant bars and restaurants, and easily navigate via bike lanes and trolley lines.
Whitehaven
1 out of top 10 points of interest in this area
Graceland mansion, a major tourist attraction, and the renovated David Carnes Park await visitors in this South Memphis neighborhood. Do some shopping at Southland Mall or explore along Elvis Presley Boulevard.
Medical District
If you're spending some time in Medical District, Sun Studio and Hunt-Phelan Home are top sights worth seeing.
South Main Hotel Deals
ARRIVE Memphis
477 S Main St Memphis TN
Fully refundableReserve now, pay when you stay
₩186,870
₩224,739 total
Sep 13 - Sep 14
includes taxes & fees
9.6/10 Exceptional! (1,056 reviews)
"A must stay in Memphis! From staff to stay this place was charming! Bravo to the interior designer!!!"
Reviewed on Aug 16, 2026
The Central Station Memphis, Curio Collection by Hilton
545 South Main Memphis TN
Fully refundableReserve now, pay when you stay
₩184,576
₩222,015 total
Aug 28 - Aug 29
includes taxes & fees
Hu. Hotel
79 Madison Avenue Memphis TN
Fully refundableReserve now, pay when you stay
₩102,626
₩127,747 total
Aug 23 - Aug 24
includes taxes & fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
How much does a South Main vacation package cost?
Choose from any combination of car rentals, flights and hotels, and you can be vacationing in South Main from just . And the more you bundle, the more you save. The getaway of your dreams has never been so affordable.
How do I get a cheap travel package to South Main?
Crafting your own South Main vacation package with Expedia is a great way to save. We have access to more than 550 airlines and 1,000,000 hotel options throughout the world. With such a fabulous range to select from, you'll have no worries pulling together your dream escape.
Where should I stay in South Main?
Make sightseeing easier by staying in a hotel just around the corner from South Main's terrific attractions. Graceland and Memphis Zoo are two traveler favorites.
What are the top hotels in South Main?
Sm 303 · Sophisticated Apartment With Historic Charm and Sm 204 · Historic Revival, Walking To Memphis' Best are two of the most well-known hotels in South Main. Why not check out the rates and amenities at each and then make a decision?
How far in advance should I book my South Main vacation?
Travelers are usually able to compare international flights on Expedia up to a year in advance of departure. Booking at the last minute? With a little bit of luck, it's still possible to nab a cheaper ticket only weeks before your journey.
What does an Expedia South Main travel package include?
Flights, hotels and a cool car for all your fun road trip adventures. Simply choose your preferred bundle and get access to incredible deals. Once you've made your booking, add on a few tours and experiences and watch your savings stack up. When it comes to organizing your South Main trip, you're in control!
What should I know before booking a South Main travel package?
So many places to go, so many things to see and do. With a travel package, you'll be able to check more of them off your list. Bundle your hotels, rental cars and flights and score big savings.
Can I choose my airline with a South Main Expedia vacation package?
Yes — and it's easy too. Expedia has access to more than 550 partner airlines globally. Our packages give you the flexibility to take your pick of available flights, hotels and activities that fit your needs.
If I'm not able to travel, can I cancel my South Main vacation package?
We totally get it — sometimes life doesn't go according to plan. If you've booked a South Main vacation package and need to change or cancel it, we can help. We recommend taking a look at our Customer Service Portal first for information. But generally, if you've taken out your package within 24 hours, you may be able to cancel or change your itinerary at no cost. If it's been more than 24 hours, your airline, hotel or car rental company may impose a charge.
Stay near popular South Main attractions
Blues Hall of Fame Museum
You can spend an afternoon studying the exhibits at Blues Hall of Fame Museum during your trip to Memphis. Wander the area's riverfront or simply enjoy one of its top-notch restaurants.
Railroad & Trolley Museum
You can spend time exploring the galleries in Railroad & Trolley Museum in Memphis. Stroll along the riverfront or attend a sporting event in this romantic area.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.