A forested valley with autumn foliage, a rocky cliff, and a sunset.

Find Resorts & Hotels with Spas in Southern Illinois, IL

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Southern Illinois Resorts & Hotels with Spas

Tonight
Oct 24 - Oct 25
Tomorrow
Oct 25 - Oct 26
Next weekend
Oct 30 - Nov 1
In two weeks
Nov 6 - Nov 8

Our top choices for Southern Illinois hotels with a spa

A modern spa room with a large hot tub, a glass wall with a reflective pattern, and a ceiling with a skylight.
A hotel lobby with a marble floor, a reception area with a '12 & VINE' sign, and a dining area with orange chairs and chandeliers.
A hotel reception desk with a modern chandelier, a sign indicating 'SPA' coming soon, and two receptionists at their stations.
A hotel lobby with a marble floor, a reception desk, a sign for 'Restrooms', and a large chandelier.

1. Walker's Bluff Casino Resort

Walker's Bluff Casino Resort
Carterville
  • Luxurious spa retreat with hot stone massages, sauna, and seasonal pools awaits at this casino resort with attentive staff and fine dining.
₩165,519
₩183,693 total
includes taxes & fees
Oct 26 - Oct 27
Walker's Bluff Casino Resort
A couple relaxing by a window overlooking a bridge and water.
A modern dining area with a long table set for a meal, large windows offering a view of a bridge, and a stone accent wall.
A modern hotel lobby with a glass facade, seating area, and a staircase.
A room with large windows overlooking a bridge and water, featuring wooden chairs and a small table.

2. Four Seasons Hotel St Louis

Four Seasons Hotel St Louis
Downtown St. Louis
  • Discover a tranquil haven with 12 treatment rooms, outdoor pool, and breathtaking views at this rejuvenating spa retreat.
₩496,159
₩580,149 total
includes taxes & fees
Oct 26 - Oct 27
Four Seasons Hotel St Louis
A modern spa with a curved reception desk, a large mirror, and a decorative water feature.
A modern tavern with a large sign, glass doors, and indoor seating visible through the windows.
An indoor swimming pool with clear glass walls, metal railings, and a tiled floor.
A bakery display case with various pastries and cakes.

3. Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa
St. Charles
  • Riverside wellness oasis offers full-service spa with aromatherapy and hydrotherapy for a restorative retreat.
₩210,637
₩268,122 total
includes taxes & fees
Nov 16 - Nov 17
Ameristar Casino Resort and Spa
A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.
An indoor swimming pool with a clear view of the pool area, including the pool's edge, a set of stairs leading into the pool, and a few lounge chairs and tables around the pool.
A hotel room with a bed, seating area, kitchenette, and a bathroom.
A buffet with labeled containers of turkey sausage and cookies.

4. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Cape Girardeau
  • Luxurious spa sanctuary awaits with full-service treatments and indoor pool in this centrally located hotel.
₩125,694
₩143,058 total
includes taxes & fees
Nov 22 - Nov 23
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
A reception desk with a wooden finish and the name "IDOL WOLF" on it.
A modern lobby with a large glass sphere, seating areas, and a reception desk.
A multi-story building with a symmetrical facade, large windows, and a central entrance with a canopy.
A hotel room with two beds, a large padded headboard, a flat-screen TV, a window with a city view, and a small side table with a plant.

5. 21C Museum Hotel St Louis

21C Museum Hotel St Louis
Downtown West
  • Discover spa services, a steam room, and an Olympic-sized indoor pool at this modern hotel, all designed for rejuvenating getaways.
₩190,062
₩228,853 total
includes taxes & fees
Nov 15 - Nov 16
21C Museum Hotel St Louis
A modern kitchen with wooden cabinets, a central island, and framed artwork on the walls.
A couple standing on a balcony with a cityscape view.
An indoor dining area with a long table, chairs, hanging plants, and a view of a brick building through large windows.
An outdoor seating area with modern furniture, a bar, and large windows offering views of a cityscape.

6. The Ritz-Carlton, St. Louis

The Ritz-Carlton, St. Louis
Clayton
  • Revel in a rejuvenating spa retreat with aromatherapy treatments and hot stone massages at this luxury St. Louis hotel.
₩766,069
₩894,290 total
includes taxes & fees
Nov 1 - Nov 2
The Ritz-Carlton, St. Louis
A two-story building with a dark entrance, large windows, and a brick facade.
A bar area with a neon sign, a lamp, and various food and drink items.
A room with a green armchair, a round table, a lamp, and a mirror on the wall.
A bathroom with a white sink, dark wooden door, and a shower area with striped glass walls.

7. Truitt Hotel

Truitt Hotel
Lafayette Square
₩222,279
₩269,831 total
includes taxes & fees
Oct 25 - Oct 26
Truitt Hotel
A two-story house with a front porch, a brick foundation, and a gabled roof.
A kitchen with white cabinets, granite countertops, a stainless steel sink, a stove, and a microwave.
A traditional interior with a wooden staircase, a desk with a computer, and a red chair.
A porch with two wicker chairs, a potted plant, and a wooden door.

8. 1895 Washington Hotel

1895 Washington Hotel
Paducah
  • Unwind in a Victorian sanctuary with relaxing reflexology and soothing hydrotherapy treatments for total rejuvenation.
₩89,454
₩121,036 total
includes taxes & fees
Oct 29 - Oct 30
1895 Washington Hotel
A dining area with a wooden table and chairs, a small Christmas tree, and a window with curtains.
A bedroom with a large bed, a nightstand with a lamp, a chair, and a framed picture on the wall.
A dining area with a red wall, a large quilt, and Christmas decorations. There is a window with a view of the outside.
Front of property

9. Arthur's Country Inn

Arthur's Country Inn
Arthur
₩156,125
₩173,272 total
includes taxes & fees
Nov 1 - Nov 2
Arthur's Country Inn
View all properties

Choose what matters most at spa hotels in Southern Illinois

Pool
Breakfast included
Hot tub
4 stars
5 stars

Top Southern Illinois Hotel Reviews

Best Western Marion Hotel

Best Western Marion Hotel

10/10 Excellent
"Overall stay and room conditions were acceptable. Only feedback to give was that the sink had low water pressure."
Niko 3-night trip
Posted 1 hour ago
Best Western Marion Hotel
Drury Inn & Suites Marion

Drury Inn & Suites Marion

10/10 Excellent
"Excellent very good High quality"
laurie 2-night trip
Posted 2 days ago
Drury Inn & Suites Marion
Drury Inn & Suites St. Louis O'Fallon, IL

Drury Inn & Suites St. Louis O'Fallon, IL

10/10 Excellent
"Staff was very friendly"
Karissa 3-night trip
Posted 2 days ago
Drury Inn & Suites St. Louis O'Fallon, IL
Quality Inn O'Fallon - St. Louis - Shiloh

Quality Inn O'Fallon - St. Louis - Shiloh

10/10 Excellent
"The only downfall was the indoor pool. I thought it would be heated. It wasn't. The kids still went in but we're shivering."
Michele 3-night trip
Posted 5 days ago
Quality Inn O'Fallon - St. Louis - Shiloh

Explore a world of travel with Expedia