Islamorada Adults Only Vacations

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Top Adults Only Islamorada Hotels

Casa Morada

Casa Morada

3.5 out of 5
136 Madeira Road Islamorada FL
  • 22 min drive from Anne's Beach
Book a stay at this beach hotel in Islamorada. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular ...
9.4/10 Exceptional! (416 reviews)
Yes

Reviewed on Dec 30, 2025

Casa Morada
Cheeca Lodge & Spa

Cheeca Lodge & Spa

5 out of 5
81801 Overseas Highway, Mile Marker 82 Islamorada FL
  • 21 min drive from Anne's Beach
Book a stay at this luxury resort in Islamorada. Enjoy free parking, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff ...
9.2/10 Wonderful! (1,288 reviews)
For a five star hotel, the grounds should be kept up better

Reviewed on Jan 14, 2026

Cheeca Lodge & Spa
See all 2,224 properties in Islamorada
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.