Eastern South Dakota Fishing Vacations

Book a Fishing Hotel + Flight or Car together to unlock savings

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    Save up to ₩234,741 when you book a flight and hotel together*
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Top Fishing Eastern South Dakota Hotels

Lewis and Clark Resort

Lewis and Clark Resort

2.5 out of 5
43496 Shore Drive, Yankton, SD
  • 2 hours drive from Denny Sanford Premier Center
Book a stay at this beach hotel in Yankton. Enjoy free WiFi, free parking, and an outdoor pool. Popular attractions Lewis and Clark Recreation Area and Midway ...
8.6/10 Excellent! (243 reviews)
"The resort is very nice although it’s a tad bit “dated.”"

Reviewed on Aug 20, 2025

Lewis and Clark Resort
Comfort Inn Yankton SD

Comfort Inn Yankton SD

2.5 out of 5
611 W 23rd Street, Yankton, SD
  • 2 hours drive from Denny Sanford Premier Center
Book a stay at this business-friendly hotel in Yankton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.8/10 Excellent! (616 reviews)
"It was very quiet in the hotel at night. No noise. Room was very clean."

Reviewed on Aug 20, 2025

Comfort Inn Yankton SD
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.