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Top Luxury San Luis Obispo Wine Country Hotels

Madonna Inn

100 Madonna Road San Luis Obispo CA

6 min drive from California Polytechnic State University

Madonna Inn delivers luxe lodging where you'll enjoy pillowtop beds and more. Notable amenities include a spa, 2 outdoor tennis courts, and an outdoor pool.

9.2/10 Wonderful! (1,319 reviews)

We love this place!

Reviewed on Dec 5, 2025

Avenue Inn Downtown San Luis Obispo

345 Marsh St San Luis Obispo CA

4 min drive from California Polytechnic State University

Be treated to luxurious accommodations at Avenue Inn Downtown San Luis Obispo, where you can enjoy amenities like premium channels, flat-screen TVs, and ...

9/10 Wonderful! (1,134 reviews)

Clean and the staff was awesome and reservation folks were very helpful

Reviewed on Nov 19, 2025

Avila La Fonda Hotel

101 San Miguel St Avila Beach CA

22 min drive from California Polytechnic State University

Enjoy a posh stay at Avila La Fonda Hotel, where you'll find private hot tubs and pillowtop beds.

9.4/10 Exceptional! (1,000 reviews)

Incredible place. Will definitely come back.

Reviewed on Nov 21, 2025

See all 1,861 properties in San Luis Obispo Wine Country

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.