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Top Luxury San Luis Obispo Wine Country Hotels

Madonna Inn

100 Madonna Road San Luis Obispo CA

6 min drive from California Polytechnic State University

Madonna Inn delivers luxe lodging where you'll enjoy pillowtop beds and more. Notable amenities include a spa, 2 outdoor tennis courts, and an outdoor pool.

9.2/10 Wonderful! (1,382 reviews)

Yes, the spa and pool were relaxing and wonderful

Reviewed on Mar 12, 2026

Avenue Inn Downtown San Luis Obispo

345 Marsh St San Luis Obispo CA

4 min drive from California Polytechnic State University

Be treated to luxurious accommodations at Avenue Inn Downtown San Luis Obispo, where you can enjoy amenities like premium channels, flat-screen TVs, and ...

9/10 Wonderful! (1,193 reviews)

The check in process was spot on. The lady behind the desk was very pleasant with a welcoming smile. The room was a king bed with seating a fridge and microwave. Check out was very friendly as well. The hotel is close to dining options and great for walking. Our stay was great.

Reviewed on Mar 13, 2026

Avila La Fonda Hotel

101 San Miguel St Avila Beach CA

22 min drive from California Polytechnic State University

Enjoy a posh stay at Avila La Fonda Hotel, where you'll find private hot tubs and pillowtop beds.

9.6/10 Exceptional! (1,001 reviews)

Always an awesome stay…thank you La Fonda

Reviewed on Mar 11, 2026

See all 1,867 properties in San Luis Obispo Wine Country

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.