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Top Luxury Florida Keys Hotels

Oceans Edge Key West Resort, Hotel & Marina

5950 Peninsular Avenue Key West FL

26 min drive from Florida Keys Beaches

Pamper yourself with a luxury stay at Oceans Edge Key West Resort, Hotel & Marina, where you can enjoy amenities like Egyptian cotton sheets, plush bedding, ...

9/10 Wonderful! (1,865 reviews)

"Fabulous ocean views! Bright and airy rooms. Staff was pleasant and helpful. I did not like the Excessive fees at checkout!! We paid for the trip in advance and was charged an additional $375.00 in fees!!!! I feel it was extremely exorbitant and unfair!!! We should be Warned !!!"

Reviewed on Jun 22, 2026

The Marker Key West Harbor Resort

200 William Street Key West FL

36 min drive from Florida Keys Beaches

Be treated to a grand stay at The Marker Key West Harbor Resort, where you'll find deep soaking bathtubs and premium bedding. The 3 outdoor pools, poolside bar, ...

9.2/10 Wonderful! (1,006 reviews)

"Great location. Room overlooking the harbor was great, as spent mornings and evenings on balcony watching all the activities."

Reviewed on Jun 22, 2026

Cheeca Lodge & Spa

81801 Overseas Highway, Mile Marker 82 Islamorada FL

3 hours drive from Florida Keys Beaches

Cheeca Lodge & Spa is a Islamorada luxury 5-star beach property where you can treat yourself to Champagne service, massage services, and more. The 2 poolside ...

9.2/10 Wonderful! (1,329 reviews)

"The decor was updated a bit but then dated in other areas. The balcony cushions had stains and the carpet needed to be replaced."

Reviewed on Jun 23, 2026

See all 8,301 properties in Florida Keys

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.