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Top Luxury Northwest Alabama Hotels

Spark by Hilton Tuscumbia Muscle Shoals

712 Hwy 72 W Tuscumbia AL

17 min drive from University of North Alabama

Be treated to luxurious accommodations at Spark by Hilton Tuscumbia Muscle Shoals, where you can enjoy amenities like pillowtop beds, designer toiletries, and ...

8.8/10 Excellent! (825 reviews)

"Just overall comfortable"

Reviewed on Nov 7, 2026

Clarion Inn Sheffield Muscle Shoals

4900 Hatch Blvd Sheffield AL

8 min drive from University of North Alabama

Pamper yourself with a luxe vacation at Clarion Inn Sheffield Muscle Shoals. Popular amenities include a nightclub, an outdoor pool, and a restaurant.

Baymont by Wyndham Florence/Muscle Shoals

115 Ana Drive Florence AL

9 min drive from University of North Alabama

Pamper yourself with an extravagant stay at Baymont by Wyndham Florence/Muscle Shoals, where you'll find deep soaking bathtubs and pillowtop beds. The outdoor ...

See all 868 properties in Northwest Alabama

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.