Central Missouri Luxury Vacations
Book a Luxury Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to ₩1,660,000 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
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Top Luxury Central Missouri Hotels
Ramada by Wyndham Columbia
901 Conley Rd Columbia MO
- 2 hours drive from Lake of the Ozarks
Ramada by Wyndham Columbia awaits for a deluxe vacation. Popular amenities include an outdoor pool and a fitness center.
7.4/10 Good! (1,000 reviews)
"Smelled like smoke."
Reviewed on Sep 27, 2026
voco The Tiger Hotel Columbia, MO by IHG
23 S 8th St Columbia MO
- 2 hours drive from Lake of the Ozarks
Pamper yourself with a luxury stay at voco The Tiger Hotel Columbia, MO by IHG, where you can enjoy amenities like 24-hour room service, pillowtop beds, and ...
9/10 Wonderful! (1,001 reviews)
"Beautiful 98 year old hotel. Wonderful amenities..very comfortable room & spacious bathroom. Wonderful toiletries too. Great drinks in the bar too! Would highly recommend this hotel!"
Reviewed on Oct 2, 2026
Lodge Of Four Seasons Golf Resort, Marina & Spa
315 Four Seasons Dr. Lake Ozark MO
- 20 min drive from Lake of the Ozarks
Pamper yourself with a luxe vacation at Lodge Of Four Seasons Golf Resort, Marina & Spa. Popular amenities include a spa, a golf course, and 5 bars.
7.4/10 Good! (1,338 reviews)
"It was ok"
Reviewed on Sep 30, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
