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Top Luxury Central Missouri Hotels

Ramada by Wyndham Columbia

901 Conley Rd Columbia MO

2 hours drive from Lake of the Ozarks

Ramada by Wyndham Columbia awaits for a deluxe vacation. Popular amenities include an outdoor pool and a fitness center.

7.6/10 Good! (1,007 reviews)

"I have stayed here before. It is a clean, quiet place to stay for a reasonable price. It is not 5 star, so if you want luxury it's not for you. The food was fine. The room had working AC and the staff was helpful. There was plenty of parking and this hotel is in a location that is easy to ..."

Reviewed on Jul 19, 2026

voco The Tiger Hotel Columbia, MO by IHG

23 S 8th St Columbia MO

2 hours drive from Lake of the Ozarks

Pamper yourself with a luxury stay at voco The Tiger Hotel Columbia, MO by IHG, where you can enjoy amenities like 24-hour room service, pillowtop beds, and ...

9/10 Wonderful! (1,001 reviews)

"Classy, old world hotel with a rich history and solid reputation that’s simply losing its luster. Have stayed here a few times in the past and this time was the worst by far!"

Reviewed on Jul 21, 2026

Lodge Of Four Seasons Golf Resort, Marina & Spa

315 Four Seasons Dr. Lake Ozark MO

20 min drive from Lake of the Ozarks

Pamper yourself with a luxe vacation at Lodge Of Four Seasons Golf Resort, Marina & Spa. Popular amenities include a spa, a golf course, and 5 bars.

7.4/10 Good! (1,239 reviews)

"It’s unfortunate we had a bad experience, but we were fully refunded."

Reviewed on Jul 21, 2026

See all 5,187 properties in Central Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.