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Top Luxury Northeast Ohio Hotels

InterContinental Cleveland by IHG

9801 Carnegie Ave Cleveland OH

4 min walk from Cleveland Clinic

Discover luxurious lodging at InterContinental Cleveland by IHG, where you can enjoy amenities like massage services, 24-hour room service, and more. Deluxe ...

9/10 Wonderful! (883 reviews)

It’s nice place to go to and relax

Reviewed on Apr 26, 2026

The Ritz-Carlton, Cleveland

1515 West Third Street Cleveland OH

10 min drive from Cleveland Clinic

Discover luxurious lodging at The Ritz-Carlton, Cleveland, where you can enjoy amenities like 24-hour room service, plush bedding, and more. The restaurant, ...

Drury Plaza Hotel Cleveland Downtown

1380 East 6th Street Cleveland OH

9 min drive from Cleveland Clinic

Visit Drury Plaza Hotel Cleveland Downtown for a relaxing stay in Cleveland. Popular amenities include an indoor pool, a restaurant, and a fitness center.

9.4/10 Exceptional! (2,743 reviews)

Honestly the best service we have ever had. Amazing hotel.

Reviewed on May 5, 2026

See all 4,283 properties in Northeast Ohio

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.