Photo by Southernmost Illinois Tourism Bureau

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Top Pet-friendly Southwest Illinois Hotels

La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis

136 Regency Park O'Fallon IL

3 hours drive from Southern Illinois University

This pet-friendly hotel welcomes dogs and cats (fees apply).

5.8/10 (1,003 reviews)

Everything was really good.

Reviewed on Jan 18, 2026

Red Roof Inn St Louis - Troy, IL

2030 Formosa Road Troy IL

3 hours drive from Southern Illinois University

Make it a pet-friendly trip and bring along your four-legged friend. Dogs and cats are welcome (fees apply) at this city-center hotel.

7.6/10 Good! (1,001 reviews)

Would stay ahain

Reviewed on Jan 18, 2026

La Quinta Inn & Suites by Wyndham Collinsville - St. Louis

6 Gateway Dr Collinsville IL

3 hours drive from Southern Illinois University

Make it a pet-friendly trip and bring along your four-legged friend. Dogs and cats are welcome (fees apply) at this city-center hotel.

7.2/10 Good! (1,004 reviews)

The room seemed claen. The bed was great, everything was great. Except for the shower, when they did a remodel they made the shower door slide the wrong way. There is zero chance of turning the water on without getting blast of cold sprayed on you! So that made me think, i see the cleaners in the ...

Reviewed on Jan 12, 2026

See all 740 properties in Southwest Illinois

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.