Photo by Southernmost Illinois Tourism Bureau

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Top Pet-friendly Southwest Illinois Hotels

La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis

136 Regency Park O'Fallon IL

3 hours drive from Southern Illinois University

This pet-friendly hotel welcomes dogs and cats (fees apply).

6/10 (1,015 reviews)

Nice place, get what you pay for.

Reviewed on Nov 26, 2025

Red Roof Inn St Louis - Troy, IL

2030 Formosa Road Troy IL

3 hours drive from Southern Illinois University

Make it a pet-friendly trip and bring along your four-legged friend. Dogs and cats are welcome (fees apply) at this city-center hotel.

7.6/10 Good! (1,004 reviews)

Would have liked a better variety for breakfast but overall stay was great.

Reviewed on Nov 25, 2025

La Quinta Inn & Suites by Wyndham Collinsville - St. Louis

6 Gateway Dr Collinsville IL

3 hours drive from Southern Illinois University

Make it a pet-friendly trip and bring along your four-legged friend. Dogs and cats are welcome (fees apply) at this city-center hotel.

7.2/10 Good! (1,015 reviews)

The bed was super comfortable - I am a super traveler and hands down the best bed next to a cruise ship. Outside the room - meh. Nothing pretty. Easy in and out from the interstate. Breakfast is a very basic "hot breakfast." Again, nothing dazzling. The room HVAC - that was a mess - I had to turn ...

Reviewed on Dec 2, 2025

See all 734 properties in Southwest Illinois

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.