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Top Romantic Upstate South Carolina Hotels

Greenville Marriott

One Parkway E Greenville SC

2 hours drive from Clemson University

Rekindle the romance with your special someone. Consider booking a getaway at this hotel where you're sure to love the premium mattresses and luxury bedding. ...

8.6/10 Excellent! (631 reviews)

The staff was ABSOLUTELY, ABSOLUTELY AMAZING!!! They were very courteous and helpful when we first walked through the main entrance and throughout our stay!!! Will definitely stay at this location again!!💕💕

Reviewed on Mar 3, 2026

Hotel Domestique

10 Road of Vines Travelers Rest SC

2 hours drive from Clemson University

Indulge in a romantic getaway at this boutique hotel, where you'll find spa services, in-room massages, and a garden. Couples will love the lobby fireplace and ...

See all 2,946 properties in Upstate South Carolina

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.