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Top Romantic Upstate South Carolina Hotels

Greenville Marriott

One Parkway E Greenville SC

2 hours drive from Clemson University

Rekindle the romance with your special someone. Consider booking a getaway at this hotel where you're sure to love the premium mattresses and luxury bedding. ...

8.4/10 Very Good! (608 reviews)

Front desk was so pleasant and helpful! Rooms were clean. Housekeeping was great too!

Reviewed on Dec 7, 2025

Hotel Domestique

10 Road of Vines Travelers Rest SC

2 hours drive from Clemson University

Indulge in a romantic getaway at this boutique hotel, where you'll find spa services, in-room massages, and a garden. Couples will love the lobby fireplace and ...

9.6/10 Exceptional! (30 reviews)

Couples like: onsite spa services, bar, champagne service, romance packages available

Travelers say...

Overall it was an exceptional experience and would highly recommend to anyone looking for a quiet get away.

Reviewed on Jul 27, 2025

See all 2,909 properties in Upstate South Carolina

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.