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Top Adventure Southeast Minnesota Hotels

Kahler Grand Hotel

20 2nd Ave Sw Rochester MN

2 min walk from Mayo Clinic

Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the helpful staff and ...

8.4/10 Very Good! (2,139 reviews)

"The close proximity to the mail Campus was extremely helpful for doctors appointments."

Reviewed on Jun 8, 2026

Willow Inn Suites Rochester

4323 Highway 52 North, West Frontage Rd Rochester MN

10 min drive from Mayo Clinic

Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff in our ...

7.4/10 Good! (1,000 reviews)

"Safe, clean, friendly and great price."

Reviewed on Apr 17, 2026

Hotel Indigo Rochester – Mayo Clinic Area by IHG

220 S Broadway Rochester MN

6 min walk from Mayo Clinic

Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the restaurant and ...

8.8/10 Excellent! (1,010 reviews)

"Very clean & comfortable and the staff were super helpful in shipping my lost items!"

Reviewed on Jun 7, 2026

See all 926 properties in Southeast Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.