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Top Luxury San Luis Obispo Wine Country Hotels

Madonna Inn

100 Madonna Road San Luis Obispo CA

6 min drive from California Polytechnic State University

Madonna Inn delivers luxe lodging where you'll enjoy pillowtop beds and more. Notable amenities include a spa, 2 outdoor tennis courts, and an outdoor pool.

9.2/10 Wonderful! (1,368 reviews)

Fun and cheeky hotel! Expensive especially dinner.

Reviewed on Jan 23, 2026

Avenue Inn Downtown San Luis Obispo

345 Marsh St San Luis Obispo CA

4 min drive from California Polytechnic State University

Be treated to luxurious accommodations at Avenue Inn Downtown San Luis Obispo, where you can enjoy amenities like premium channels, flat-screen TVs, and ...

9/10 Wonderful! (1,158 reviews)

Yes, was very comfortable.

Reviewed on Jan 21, 2026

Avila La Fonda Hotel

101 San Miguel St Avila Beach CA

22 min drive from California Polytechnic State University

Enjoy a posh stay at Avila La Fonda Hotel, where you'll find private hot tubs and pillowtop beds.

9.4/10 Exceptional! (1,002 reviews)

This hotel is a gem if you are looking for a botique style stay. The design is colorful with a lot of attention to details. The rooms are spacious and comfortable. Everything is clean. The service is extremely friendly and welcoming. There are a number of complimentary food servings during the day ...

Reviewed on Jan 21, 2026

See all 1,861 properties in San Luis Obispo Wine Country

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.