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Top Luxury Eastern Tennessee Hotels

Carnegie Hotel & Spa

1216 W State Of Franklin Rd Johnson City TN

2 hours drive from Great Smoky Mountains National Park

Treat yourself to upscale accommodations at Carnegie Hotel & Spa, where you'll enjoy amenities like premium channels and more. Notable amenities include a spa, ...

9.6/10 Exceptional! (1,326 reviews)

Great old vibe. Quality characterized most aspects.

Reviewed on Jan 21, 2026

THE TENNESSEAN Hotel

531 Henley Street Knoxville TN

55 min drive from Great Smoky Mountains National Park

Treat yourself to a luxury stay at THE TENNESSEAN Hotel, where you can enjoy amenities like pillowtop beds, designer toiletries, and more. The restaurant, fitness ...

9.4/10 Exceptional! (1,004 reviews)

Wonderful stay

Reviewed on Jan 16, 2026

The Read House Hotel

107 West Martin Luther King Blvd Chattanooga TN

4 hours drive from Great Smoky Mountains National Park

Go for a luxurious stay at The Read House Hotel, where you can enjoy amenities like Champagne service, plush bedding, and more. The indoor pool, restaurant, ...

9.4/10 Exceptional! (2,348 reviews)

Room was spotless, old but nice. Staff was wonderful

Reviewed on Jan 20, 2026

See all 25,824 properties in Eastern Tennessee

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.