Southeast Missouri Pet-friendly Vacations
Book a Pet-friendly Hotel + Flight or Car together to unlock savings
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- Better togetherSave up to ₩1,660,000 when you book a flight and hotel together*
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Top Pet-friendly Southeast Missouri Hotels
Motel 6 Poplar Bluff, MO
4101 Highway 67 N Poplar Bluff MO
- 3 hours drive from Mark Twain National Forest
Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
Microtel Inn & Suites by Wyndham Sainte Genevieve
21958 Hwy 32 Ste Genevieve MO
- 4 hours drive from Mark Twain National Forest
Book a stay at this business-friendly hotel in Ste Genevieve. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
8.8/10 Excellent! (665 reviews)
"The Breakfast items were a bit stale. Staff was not super helpful."
Reviewed on Aug 11, 2026
La Quinta Inn & Suites by Wyndham Festus - St. Louis South
1001 Veterans Blvd Festus MO
- 3 hours drive from Mark Twain National Forest
This hotel is pet-friendly, allowing dogs and cats with an additional fee. If you're going for a walk during your stay, swing by nearby Jorkerst Memorial ...
7.8/10 Good! (1,002 reviews)
"The pool was completely green. The flooring in the room was broken in a bunch of spots and the shower was yellow on almost all the walls. The air conditioner barely worked and had a lot of dust built up on the vents."
Reviewed on Aug 14, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
