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Top Pet-friendly Eastern South Dakota Hotels

La Quinta Inn & Suites by Wyndham Sioux Falls

4521 W. 41st Street Sioux Falls SD

9 min drive from Denny Sanford Premier Center

Dogs and cats may join you (for a fee) during your stay at this pet-friendly hotel. Take the opportunity to stretch your legs on the nearby hiking or biking ...

9.2/10 Wonderful! (1,564 reviews)

Clean Quiet

Reviewed on May 10, 2026

Econo Lodge Sioux Falls Empire Mall

3500 Gateway Boulevard Sioux Falls SD

9 min drive from Denny Sanford Premier Center

This pet-friendly hotel welcomes dogs and cats (fees apply).

7/10 Good! (442 reviews)

Economy hotel, no thrills, but it's nice

Staff was really nice. Rooms are spacious. Good value and convenient to many stores/restaurants, etc. Rooms for clean.

Reviewed on Oct 18, 2022

Kelly Inn & Suites Mitchell South Dakota

1010 Cabela Drive Mitchell SD

3 hours drive from Denny Sanford Premier Center

This pet-friendly hotel welcomes dogs for free.

8/10 Very Good! (1,094 reviews)

Was a lot better then most places we have stayed at

Reviewed on May 10, 2026

See all 947 properties in Eastern South Dakota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.