Upstate South Carolina 4 Stars Hotels

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Our top choices for Upstate South Carolina 4-star hotels

Exterior

Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection
4.0 star property
Greenville Downtown
9.6 out of 10, Exceptional, (472 reviews)
"Beautiful and comfortable! We loved it and wish we could have stayed longer than one night!"
United States
Nancy
The price is ₩473,138
₩534,646 total
includes taxes & fees
Apr 19 - Apr 20
Grand Bohemian Lodge Greenville, Autograph Collection
Restaurant

Hotel Hartness

Hotel Hartness
4.0 star property
Greenville
9.8 out of 10, Exceptional, (694 reviews)
"Great place"
United States
Helen
The price is ₩237,754
₩311,664 total
includes taxes & fees
Apr 26 - Apr 27
Hotel Hartness
Lobby

The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
4.0 star property
Clemson
9.8 out of 10, Exceptional, (784 reviews)
"Excellent stay, I highly recommend! Accommodations, location, overall vibe, great food and drinks! "
United States
Julie
The price is ₩295,155
₩327,622 total
includes taxes & fees
Apr 14 - Apr 15
The Shepherd Hotel Downtown Clemson
Deluxe Two Bedroom (Self Check-in with Virtual Front Desk) | Living area | 55-inch flat-screen TV with digital channels, TV, streaming services

Mint House Greenville Downtown by Kasa

Mint House Greenville Downtown by Kasa
4.0 star property
Greenville Downtown
9.2 out of 10, Wonderful, (810 reviews)
"Very clean, nice amenities. Plenty of space and a great location. "
United States
Dawn
The price is ₩165,524
₩182,077 total
includes taxes & fees
Apr 27 - Apr 28
Mint House Greenville Downtown by Kasa
Exterior

The Westin Poinsett Greenville

The Westin Poinsett Greenville
4.0 star property
Greenville Downtown
9.2 out of 10, Wonderful, (1,003 reviews)
"Great hotel Great location Great room Friendly and courteous staff"
United States
Charles
The price is ₩324,819
₩357,301 total
includes taxes & fees
Apr 26 - Apr 27
The Westin Poinsett Greenville
Bar (on property)

Greenville Marriott

Greenville Marriott
4.0 star property
Greenville
8.6 out of 10, Excellent, (637 reviews)
"The airport shuttle arrived within 10 minutes of dispatch and the hotel and restaurant staff were very friendly and accommodating. "
United States
Leslie
The price is ₩194,298
₩220,772 total
includes taxes & fees
Apr 18 - Apr 19
Greenville Marriott
Lobby lounge

The Abernathy of Clemson

The Abernathy of Clemson
4.0 star property
Clemson
9.6 out of 10, Exceptional, (587 reviews)
"Excellent location to visit Clemson. Staff is very friendly. Rooms are clean spacious. "
United States
Linda
The price is ₩225,593
₩250,408 total
includes taxes & fees
Apr 14 - Apr 15
The Abernathy of Clemson
Trailside Wedge Cottage | Terrace/patio

The Station by Compo Hotels

The Station by Compo Hotels
4.0 star property
Travelers Rest
10.0 out of 10, Exceptional, (19 reviews)
"great place perfect for more privacy vs. a standard hotel"
United States
John
The price is ₩336,187
₩492,168 total
includes taxes & fees
Apr 14 - Apr 15
The Station by Compo Hotels
Front of property

Liberty Hall Bed and Breakfast

Liberty Hall Bed and Breakfast
4.0 star property
Pendleton
10.0 out of 10, Exceptional, (87 reviews)
"The was by far one of the best bed and breakfast places that I have ever stayed in. The house is beautiful, the rooms and spotless and the breakfast is amazing. "
United States
Jennifer Ann
The price is ₩180,756
₩274,820 total
includes taxes & fees
May 10 - May 11
Liberty Hall Bed and Breakfast
Courtyard

Hotel Domestique

Hotel Domestique
4.0 star property
Travelers Rest
9.8 out of 10, Exceptional, (33 reviews)
"Overall it was an exceptional experience and would highly recommend to anyone looking for a quiet get away."
United States
Chuck
The price is ₩636,289
₩699,918 total
includes taxes & fees
May 12 - May 13
Hotel Domestique
Lobby

Landing Apartments Greer - Sugar Creek

Landing Apartments Greer - Sugar Creek
4.0 star property
Greer
Landing Apartments Greer - Sugar Creek
Apartment (2 Bedrooms) | Interior

Luxe Keowee Key Living: Golf Views & Resort Pool

Luxe Keowee Key Living: Golf Views & Resort Pool
4.0 star property
Salem
Luxe Keowee Key Living: Golf Views & Resort Pool
Apartment, 1 Bedroom | Private kitchen | Full-size fridge, microwave, oven, stovetop

Park Place Apartments by Landing

Park Place Apartments by Landing
4.0 star property
Greenville
7.6 out of 10, Good, (46 reviews)
"Loved the apartment! Very spacious, clean, brand new. Access to bike paths. Seemed like a quirky location but everything is close by car or bike. "
United States
Kathie
Park Place Apartments by Landing
Apartment (2 Bedrooms) | Interior

Private Balcony: Lake Keowee Home w/ Pool Access

Private Balcony: Lake Keowee Home w/ Pool Access
4.0 star property
Salem
Private Balcony: Lake Keowee Home w/ Pool Access
Apartment (1 Bedroom) | Interior

Designer Retreat w/ Pool, Golf + Beach Access!

Designer Retreat w/ Pool, Golf + Beach Access!
4.0 star property
Salem
10.0 out of 10, Exceptional, (1 review)
"Property is in a great community, and it was very clean and beautifully decorated."
United States
Anonymous traveler
Designer Retreat w/ Pool, Golf + Beach Access!
Apartment (3 Bedrooms) | Interior

Keowee Key Condo w/ Lake Access & Community Pools!

Keowee Key Condo w/ Lake Access & Community Pools!
4.0 star property
Salem
Keowee Key Condo w/ Lake Access & Community Pools!
Apartment (2 Bedrooms) | Interior

Views, Pools & Marina: Lake Keowee Condo!

Views, Pools & Marina: Lake Keowee Condo!
4.0 star property
Salem
Views, Pools & Marina: Lake Keowee Condo!
Apartment (3 Bedrooms) | Interior

5 Mi to Memorial Stadium & Beach: Modern Townhome

5 Mi to Memorial Stadium & Beach: Modern Townhome
4.0 star property
Central
5 Mi to Memorial Stadium & Beach: Modern Townhome
Apartment (2 Bedrooms) | Interior

Lake Keowee Condo: Resort Pools & Lake Access!

Lake Keowee Condo: Resort Pools & Lake Access!
4.0 star property
Salem
10.0 out of 10, Exceptional, (1 review)
Lake Keowee Condo: Resort Pools & Lake Access!
Apartment (4 Bedrooms) | Interior

Salem Vacation Rental w/ Lake Keowee Access!

Salem Vacation Rental w/ Lake Keowee Access!
4.0 star property
Salem
Salem Vacation Rental w/ Lake Keowee Access!
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Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, restaurants, and sights from Discovery Island Water Park to Frankie's Fun Park.

See all hotels in Upstate South Carolina
Photo by Visit Greenville, South Carolina
Open Photo by Visit Greenville, South Carolina

Top Upstate South Carolina Hotel Reviews

Hotel Hartness

Hotel Hartness

10/10 Excellent
"The BEST hotel experience. My husband and I lived in Greenville years ago and decided to visit. From the very minute you pull up until you leave, it’s an excellent experience. "
Adrienne 2-night trip
Posted 2 days ago
Hotel Hartness

Frequently asked questions

What are the best 4-star hotels in Upstate South Carolina?
Stay at Greenville Marriott and get ready for upscale comfort and plenty of handy amenities. This 4-star hotel in Greer, Upstate South Carolina, is highly recommended by Expedia guests.
How much does it cost to stay in a 4-star hotel in Upstate South Carolina?
Expedia can help you quickly locate the perfect 4-star hotel for your getaway in Upstate South Carolina. Use our handy filter tool to tailor your search by things like amenities, budget and property star rating and get access to fabulous deals in a few clicks.

  • Search for the lowest price from ₩182,077

What's the difference between 5-star and 4-star hotels in Upstate South Carolina?
Offering a friendly guest experience and upmarket décor, 4-star hotels are a wonderful option for your Upstate South Carolina trip. These kinds of accommodations generally come with loads of handy amenities that make it simple to kick back and relax — think large beds, bathrobes, restaurants and pools. Or live the high life at a 5-star hotel designed to pamper with exclusive perks and amenities. Full-service health clubs, premium toiletries and fine dining are typically featured at these deluxe retreats.