Our top choices for Upstate South Carolina hotels

Egyptian cotton sheets, premium bedding, pillowtop beds, in-room safe

1. Days Inn by Wyndham Greenville South/Mauldin

Mauldin

Scott

₩112,680 total

includes taxes & fees

Jul 19 - Jul 20

2. Embassy Suites Greenville Golf Resort & Conference Center

Greenville

Bonita

₩184,524 total

includes taxes & fees

Aug 2 - Aug 3

3. Best Western Plus Greenville I-385 Inn & Suites

Greenville

Shabana

₩170,196 total

includes taxes & fees

Aug 2 - Aug 3

4. Drury Inn & Suites Greenville

Greenville

Aaron

₩188,182 total

includes taxes & fees

Aug 17 - Aug 18

5. Comfort Suites Greenville Airport

Greenville

Cecilia

₩165,659 total

includes taxes & fees

Aug 9 - Aug 10

6. Clarion Greenville Airport Inn

Greenville

Gladys

₩114,064 total

includes taxes & fees

Aug 8 - Aug 9

7. Clemson University's James F. Martin Inn

Clemson

Jesse

₩237,799 total

includes taxes & fees

Jul 19 - Jul 20

8. Lakeside Lodge Clemson

Seneca

JEFFREY

₩201,305 total

includes taxes & fees

Jul 20 - Jul 21

9. SpringHill Suites by Marriott Greenville Downtown

Greenville Downtown

Samir

₩202,436 total

includes taxes & fees

Aug 16 - Aug 17

Single Room, 1 King Bed, Non Smoking | Desk, laptop workspace, WiFi (free)

10. Deluxe Inn

Mauldin

Diane

₩109,908 total

includes taxes & fees

Jul 21 - Jul 22

11. The Inn at Patrick Square

Clemson

Karyn

₩246,056 total

includes taxes & fees

Jul 19 - Jul 20

12. Fairfield Inn & Suites by Marriott Greenville Simpsonville

Simpsonville

Carole

₩137,704 total

includes taxes & fees

Jul 26 - Jul 27

13. La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

Greenville

Anthony

₩133,509 total

includes taxes & fees

Aug 13 - Aug 14

14. Hampton Inn Anderson/ Alliance Business Park

Anderson

meagan

₩187,465 total

includes taxes & fees

Aug 1 - Aug 2

Suite, 1 King Bed with Sofa bed, Non Smoking (Efficiency) | Premium bedding, desk, laptop workspace, blackout drapes

15. Comfort Inn & Suites Clemson - University Area

Clemson

Lon

₩174,055 total

includes taxes & fees

Aug 17 - Aug 18

16. Best Western Plus Clemson Hotel & Conference Center

Clemson

Tammy

₩181,072 total

includes taxes & fees

Aug 17 - Aug 18

17. Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG

Anderson

Edna

₩158,740 total

includes taxes & fees

Aug 2 - Aug 3

18. Hampton Inn & Suites Greenville Airport, SC

Greenville

Dianna

₩183,931 total

includes taxes & fees

Aug 15 - Aug 16

19. La Quinta by Wyndham Haywood Mall-Near Greenville Downtown

Greenville

Wade

₩125,191 total

includes taxes & fees

Jul 22 - Jul 23

Outdoor pool, open 9:00 AM to 9:00 PM, sun loungers

20. Fairfield Inn & Suites by Marriott Anderson Clemson

Anderson

Malerion

₩162,000 total

includes taxes & fees

Aug 3 - Aug 4

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Vacation Rentals in Upstate South Carolina

Aparthotel

Coffee/tea maker, full-size fridge, microwave, oven

stayAPT Suites Greenville-Haywood Mall

Greenville

"This is a great hotel for the price!!"

Apartment

Deluxe Two Bedroom (Self Check-in with Virtual Front Desk) | Living area | 55-inch flat-screen TV with digital channels, TV, streaming services

Mint House Greenville Downtown by Kasa

Greenville Downtown

"Love the location. Room was great."

Cottage

< 3 Mi to Dtwn: Modern Cottage in Greenville!

Greenville

Cabin

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

"Awesome place "

Mobile Home

Cabin, 2 Bedrooms, Non Smoking (No Pets, Linens Included) | In-room dining

Carolina Landing RV Resort - Caravan Park

Fair Play

"Very nice stay with friendly staff"

Cottage

Cozy Home in Historic Area ~ 2 Mi to Main St!

Greenville

"Absolutely adorable property. Little bit of an interesting part of town. We weren’t spending a bunch of time on property so it didn’t mater. Super close to down town and the house is well kept. "

Cottage

Claires Cottage ~ 4 Mi to Downtown Greenville!

Greenville

"Great trip. The small cottage was perfect for my wife and I and the owner was very responsive."

Cottage

2 Mi to Downtown: Luxe Greenville Retreat!

Greenville

"Great house! Very clean and comfortable. Outstanding amenities. Conveniently located. "

Cottage

Cozy Greenville Bungalow ~ 2 Mi to Downtown!

Greenville

"Amazing place. Great host. "

Cottage

Stay at Jos Taylor Retreat: 9 Mi to Greenville!

Taylors

"This rental is a time capsule that takes you back to Grandma and Grandpa's home. The owner is great to communicate with, as well as their property manager. Quaint older furniture, complete with blankets on the couches. There's all you need to cook and even a great cast-iron frying pan. I wish we had stayed here longer."

Cottage

Families Welcome, Fenced Yard: Inviting Greer Home

Greer

"This property is such an amazing find. Three large bedrooms, very clean and well maintained. Close to town of Greer and all amenities. Very easy check-in. Beds very comfortable. Kitchen well equipped for the week we were there."

Apartment

Serene Travelers Rest Apartment: 7 Mi to Downtown!

Travelers Rest

"The best time ever. My wife and I enjoyed our Honeymoon and stay here. We will come back every year for our Anniversary now and also to vacation here. The area was beautiful, quiet, and safe. We had everything we needed. No other vacation spot in South Carolina can compete. Thank you for our wonderful stay and perfect memories! "

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Stay near popular Upstate South Carolina attractions

A historic building with a clock tower, surrounded by a well-maintained lawn with a paw print design.

Clemson University

9.6/10 (1,439 reviews)

Walk around the campus of Clemson University, a top university in Clemson. Experience the area's theater scene or attend a football game.

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Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, restaurants, and sights from Discovery Island Water Park to Frankie's Fun Park.

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