A calm river with boats, lush greenery, and a clear blue sky.

Big Pine Key 5 Stars Hotels

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Our top choices for Big Pine Key 5-star hotels

On the beach, sun loungers, beach umbrellas, beach towels

Isla Bella Beach Resort & Spa

Isla Bella Beach Resort & Spa
5.0 star property
Marathon
9.2 out of 10, Wonderful, (1,188 reviews)
"Beautiful resort will.be going back"
United States
Robert
The price is ₩382,394
₩522,652 total
includes taxes & fees
Jul 19 - Jul 20
Isla Bella Beach Resort & Spa
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Big Pine Key.
Faro Blanco Resort Marathon Florida Keys, Curio by Hilton

Faro Blanco Resort Marathon Florida Keys, Curio by Hilton

1996 Overseas Highway Marathon FL
The price is ₩233,454 per night from Jul 21 to Jul 22
₩233,454
₩319,254 total
Jul 21 - Jul 22
includes taxes & fees
8.6/10 Excellent! (1,171 reviews)
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Big Pine Key

Snorkel crystal-clear waters teeming with colorful fish, then spot adorable Key deer at the National Key Deer Refuge. Unwind on pristine beaches like Calusa or Sandspur, where soft sand meets turquoise waves.

See all hotels in Big Pine Key
A beach with clear turquoise water, a red umbrella, and a bridge in the background.

Top Big Pine Key Hotel Reviews

Isla Bella Beach Resort & Spa

Isla Bella Beach Resort & Spa

10/10 Excellent
"Beautiful stay for our honeymoon, very worth it!"
Kobe 4-night trip
Posted 13 hours ago
Isla Bella Beach Resort & Spa

Frequently asked questions

How much does it cost to stay in a 5-star hotel in Big Pine Key?
You'll find a variety of pricing options for 5-star hotels in Big Pine Key on Expedia. The amount you pay will depend on when you want to travel, trip length and other factors. Compare all of the available accommodations for your chosen dates and make use of our pricing and other filters to find the ideal high-end stay.

  • Search for the lowest price per night from ₩319,254

What makes a hotel 5 stars in Big Pine Key?
Flawless guest service characterizes every 5-star hotel in Big Pine Key. From the moment you enter the lobby, staff attend to your every whim, whether recommending activities or providing a turn-down service. Also, hotels have to offer superior conveniences to obtain a 5-star rating. These can include luxury bath products, saunas or spas, swimming pools, gastronomic restaurants and knowledgeable concierge.
Are there any 5-star all-inclusive resorts in Big Pine Key?
Use our handy filters to find an upscale retreat in Big Pine Key where most of what you need is included. Next, narrow your results for properties that have 5 stars and are described as "All inclusive." The most important thing on the agenda at these stays? Pure enjoyment and indulgence.