Panama Canal Zone 5 Stars Hotels

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Panama Canal Zone 5 Star Hotels

Tonight
Dec 30 - Dec 31
Tomorrow
Dec 31 - Jan 1
This weekend
Jan 2 - Jan 4
Next weekend
Jan 9 - Jan 11

Our top choices for Panama Canal Zone 5-star hotels

Outdoor pool, sun loungers
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama
5.0 star property
Bella Vista
9.0 out of 10, Wonderful, (4744)
"The rooms were nice and the food was great..great staff!!"
United States
Tffany
The price is ₩175,075
₩192,583 total
includes taxes & fees
Jan 12 - Jan 13, 2026
Hotel Riu Plaza Panama
View from property
Waldorf Astoria Panama

Waldorf Astoria Panama

Waldorf Astoria Panama
5.0 star property
Bella Vista
9.0 out of 10, Wonderful, (1002)
"Lovely stay and lovely price. Luxury in Panama "
United States
Kelinde
The price is ₩315,359
₩346,895 total
includes taxes & fees
Jan 10 - Jan 11, 2026
Waldorf Astoria Panama
2 restaurants, local cuisine
W Panama

W Panama

W Panama
5.0 star property
Bella Vista
9.0 out of 10, Wonderful, (1000)
"staff and food are amazing "
Canada
Judy
The price is ₩268,851
₩295,736 total
includes taxes & fees
Jan 30 - Jan 31, 2026
W Panama
4 outdoor pools, free cabanas, pool umbrellas
JW Marriott Panama

JW Marriott Panama

JW Marriott Panama
5.0 star property
San Francisco
9.0 out of 10, Wonderful, (1005)
"Bedroom was very comfy, also the staff were very on point. I will definitely recommend this hotel and there services, there is so much to do at this hotel."
United States
Sarran
The price is ₩384,584
₩423,042 total
includes taxes & fees
Jan 30 - Jan 31, 2026
JW Marriott Panama
Exterior
Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City
5.0 star property
Casco Viejo
9.8 out of 10, Exceptional, (568)
"Amazing hotel , location , staff and amenities . Clean, elegant , great service. "
United States
Nicole
The price is ₩510,396
₩561,436 total
includes taxes & fees
Jan 13 - Jan 14, 2026
Sofitel Legend Casco Viejo, Panama City
Outdoor pool
Hilton Panama

Hilton Panama

Hilton Panama
5.0 star property
Bella Vista
8.8 out of 10, Excellent, (1003)
"The restaurant at the pool, Caio Lagazzi, was amazing. The Hilton breakfast was top notch, except that they were a little slow bringing drinks (but to be fair it was Christmas day and they may have been understaffed). "
United States
Elmer
The price is ₩288,052
₩316,857 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Hilton Panama
3 outdoor pools, pool umbrellas, sun loungers
The Westin Playa Bonita Panama

The Westin Playa Bonita Panama

The Westin Playa Bonita Panama
5.0 star property
Veracruz
8.0 out of 10, Very Good, (1004)
"Beautiful property and amazing staff"
United States
CARMEN
The price is ₩338,434
₩372,278 total
includes taxes & fees
Jan 9 - Jan 10, 2026
The Westin Playa Bonita Panama
40-inch Smart TV with cable channels, TV
Renaissance Panama City Hotel

Renaissance Panama City Hotel

Renaissance Panama City Hotel
5.0 star property
Bella Vista
9.0 out of 10, Wonderful, (102)
"I stayed for nine nights and I enjoyed my time at this hotel I recommend this hotel for several days staff is nice and the hotel is worth it. "
United States
Sharon Isoken
The price is ₩165,843
₩182,428 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Renaissance Panama City Hotel
Couples treatment rooms, sauna, steam room, body treatments
Bristol Panama, a Registry Collection Hotel

Bristol Panama, a Registry Collection Hotel

Bristol Panama, a Registry Collection Hotel
5.0 star property
Bella Vista
9.4 out of 10, Exceptional, (1004)
"Great staff, super accommodating. Best place to stay in Panama!"
United States
Sebastian
The price is ₩276,643
₩304,307 total
includes taxes & fees
Jan 31 - Feb 1, 2026
Bristol Panama, a Registry Collection Hotel
Suite, 1 Bedroom, Golf View (Terrace) | Premium bedding, minibar, in-room safe, desk
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
5.0 star property
Juan Diaz
9.6 out of 10, Exceptional, (644)
"As usual the stay was amazing in this hotel"
United States
Jose
The price is ₩320,606
₩352,666 total
includes taxes & fees
Jan 4 - Jan 5, 2026
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
View from property
Megapolis Hotel Panamá

Megapolis Hotel Panamá

Megapolis Hotel Panamá
5.0 star property
San Francisco
8.4 out of 10, Very Good, (1001)
"Great stay! Very safe!"
United States
MARVIN
Megapolis Hotel Panamá
Outdoor pool
Waymore Hotel Spa and Casino

Waymore Hotel Spa and Casino

Waymore Hotel Spa and Casino
5.0 star property
Bella Vista
6.2 out of 10, (1000)
"It has a nice casino and it's very conveniently located. Breakfast was very good as well. Staff very helpful and attention oriented. Good experience "
United States
Aldo
Waymore Hotel Spa and Casino
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Panama Canal Zone.
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

Ave. Domingo Diaz Tocumen Panama
The price is ₩157,265 per night from Jan 8 to Jan 9
₩157,265
₩172,991 total
Jan 8 - Jan 9, 2026
includes taxes & fees
8.4/10 Very Good! (2,324 reviews)
Still don't see what you're looking for?
See all properties in Panama Canal Zone.
You can also use these popular filters to refine your search.
PoolSpaHot tubBreakfast includedWaterpark
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Panama Canal Zone

Explore the relaxing area of Panama Canal Zone—natural beauty, golf courses, and popular sights like Albrook Shopping Mall.

See all hotels in Panama Canal Zone
0_BU000512

Top Panama Canal Zone Hotel Reviews

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

10/10 Excellent
"Great Staff. Wonderful berakfast. Pool guy worked very hard to straighten lounge chairs, bring freah towels, lower umbrella. Room was on 27th floor with fogged over window. So we requested a different room with a view. They accommodated and gave us 31st floor with a great view. Overall a great experience. We took Uber everywhere we needed to go. Was inexpensive to Uber. For day trips old town was our favorite, Anton Hill hike, and the Causway were fun. "
Jacque 5-night trip
Posted 15 hours ago
Hotel Riu Plaza Panama

Frequently asked questions

How much does it cost to stay in a 5-star hotel in Panama Canal Zone?
The amount you pay for a 5-star hotel in Panama Canal Zone depends on things like when you plan to go and the length of your vacation. Our insider tip for bagging an awesome deal? Use our pricing filters to compare all of the available accommodations for your selected dates.

  • Search for the lowest price per night from ₩172,991

What makes a hotel 5 stars in Panama Canal Zone?
In Panama Canal Zone, a hotel must offer a specific number of upscale features to earn 5 stars. These may include gourmet restaurants, saunas and spas, on-site gyms, premium bedding, complimentary luxury toiletries and more. What also sets 5-star hotels apart is their exceptional standard of service. You'll enjoy things like concierge services, nightly turn-down services and in-room massage. Some may even offer extra touches such as a welcome gift.
Are there any 5-star all-inclusive resorts in Panama Canal Zone?
Expedia's filters are the quickest way to narrow down what you're looking for. Check the "All inclusive" and "5-star" boxes to see the most luxurious hotels in Panama Canal Zone where your meals, room, entertainment and activities are included in the price. At these getaways, your vacation is pure extravagance from the moment you check in.