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Our top choices for Buffalo Museum of Science hotels

A grand staircase with ornate woodwork and a chandelier, leading to a room with a large wooden door and a stained glass window.

1. InnBuffalo off Elmwood

InnBuffalo off Elmwood
2.5 star property
Elmwood Village, 3 km from Buffalo Museum of Science
10.0 out of 10, Exceptional, (225 reviews)
"Friendly staff, clean and amazing breakfast"
Germany
Terese
The price is ₩178,990
₩205,381 total
includes taxes & fees
Nov 10 - Nov 11
InnBuffalo off Elmwood
A spacious room with a wooden floor, a fireplace, a dining table, and several chairs.

2. Buffalo Harmony House

Buffalo Harmony House
4.5 star property
Allentown, 3.2 km from Buffalo Museum of Science
10.0 out of 10, Exceptional, (58 reviews)
"Beautiful place. Great breakfasts. Wonderful staff."
United States
John
The price is ₩442,645
₩514,762 total
includes taxes & fees
Nov 11 - Nov 12
Buffalo Harmony House
A spacious dining area with a long table, multiple chairs, a chandelier, and a fireplace.

3. The Edward Hotel

The Edward Hotel
3.0 star property
Elmwood Village, 2.4 km from Buffalo Museum of Science
9.6 out of 10, Exceptional, (270 reviews)
"This place was quiet and clean and soooo comfortable."
United States
Grace
The price is ₩203,428
₩280,119 total
includes taxes & fees
Nov 15 - Nov 16
The Edward Hotel
A two-story building with a white exterior, a red door, and large windows.

4. Buffalo Guesthouse

Buffalo Guesthouse
4.0 star property
Allentown, 2.4 km from Buffalo Museum of Science
9.4 out of 10, Exceptional, (231 reviews)
"Excellent location and service."
United States
Jose
The price is ₩237,560
₩272,600 total
includes taxes & fees
Nov 9 - Nov 10
Buffalo Guesthouse
A grand entrance with a staircase leading to a door, surrounded by lush greenery and a well-maintained garden.

5. The Mansion On Delaware Ave

The Mansion On Delaware Ave
4.0 star property
Allentown, 3 km from Buffalo Museum of Science
9.4 out of 10, Exceptional, (1,003 reviews)
"Great place to stay!"
United States
Marilyn
The price is ₩269,099
₩308,791 total
includes taxes & fees
Nov 12 - Nov 13
The Mansion On Delaware Ave
A modern hotel lobby with a bar area, seating, and a large TV screen.

6. Residence Inn by Marriott Buffalo Downtown

Residence Inn by Marriott Buffalo Downtown
3.0 star property
Allentown, 2.6 km from Buffalo Museum of Science
9.2 out of 10, Wonderful, (390 reviews)
"Spacious room, friendly staff, and great location in Buffalo."
United States
Karen
The price is ₩254,149
₩296,718 total
includes taxes & fees
Nov 24 - Nov 25
Residence Inn by Marriott Buffalo Downtown
A spacious lobby with a large sofa, a coffee table, and potted plants. There is a decorative wall with a painting and a large window providing natural light.

7. Wyndham Garden Buffalo Downtown

Wyndham Garden Buffalo Downtown
3.0 star property
Downtown Buffalo, 1.9 km from Buffalo Museum of Science
9.0 out of 10, Wonderful, (1,897 reviews)
"Was a great stay"
United States
Sara
The price is ₩207,729
₩242,524 total
includes taxes & fees
Nov 9 - Nov 10
Wyndham Garden Buffalo Downtown
A hotel room with a bed, desk, chair, TV, and a bathroom with a sink and mirror.

8. Best Western on the Avenue

Best Western on the Avenue
2.5 star property
Allentown, 2.8 km from Buffalo Museum of Science
8.8 out of 10, Excellent, (1,011 reviews)
"Great place to stay."
United States
James
The price is ₩207,674
₩242,460 total
includes taxes & fees
Nov 23 - Nov 24
Best Western on the Avenue
A hotel lobby with seating areas, a coffee table, and a lamp.

9. Holiday Inn Express & Suites Buffalo Downtown - Medical CTR by IHG

Holiday Inn Express & Suites Buffalo Downtown - Medical CTR by IHG
2.5 star property
Buffalo Theater District, 3.1 km from Buffalo Museum of Science
8.6 out of 10, Excellent, (1,010 reviews)
"We liked our stay."
United States
Daniel
The price is ₩165,200
₩192,871 total
includes taxes & fees
Dec 8 - Dec 9
Holiday Inn Express & Suites Buffalo Downtown - Medical CTR by IHG
A dining area with a wooden table and chairs, a fireplace, and large windows with a view of greenery outside.

10. Summer Street Guest House

Summer Street Guest House
3.0 star property
Bryant, 3 km from Buffalo Museum of Science
9.6 out of 10, Exceptional, (4 reviews)
"Charles greeted us upon arrival and took us on a tour of his beautiful house. It was magnificent. Spacious and well-appointed. A terrific stay!"
Canada
Anthony
The price is ₩490,276
₩719,260 total
includes taxes & fees
Nov 22 - Nov 23
Summer Street Guest House
A lobby with a staircase, seating area, and a view of the outdoors.

11. Lenox Hotel and Suites

Lenox Hotel and Suites
2.5 star property
Allentown, 2.6 km from Buffalo Museum of Science
8.2 out of 10, Very good, (133 reviews)
"Enjoyed our stay"
United States
Thomas
The price is ₩142,438
₩163,448 total
includes taxes & fees
Dec 6 - Dec 7
Lenox Hotel and Suites
A rooftop terrace with wicker furniture, a bar area, and a view of the cityscape.

12. Aloft by Marriott Buffalo Downtown

Aloft by Marriott Buffalo Downtown
3.0 star property
Buffalo Theater District, 3 km from Buffalo Museum of Science
8.2 out of 10, Very good, (369 reviews)
"Run don’t walk from this hotel. Three hundred dollars for a Motel 6 room."
United States
Anthony T
The price is ₩244,660
₩285,640 total
includes taxes & fees
Nov 29 - Nov 30
Aloft by Marriott Buffalo Downtown
A buffet setup with various food items and utensils.

13. Salvatores Grand Hotel

Salvatores Grand Hotel
3.0 star property
13.1 km from Buffalo Museum of Science
9.6 out of 10, Exceptional, (1,009 reviews)
"Loved this place! It was very unique, clean, and the staff was very helpful. Definitely will stay again next time in Buffalo."
United States
Mary
The price is ₩230,734
₩262,463 total
includes taxes & fees
Nov 22 - Nov 23
Salvatores Grand Hotel
A hotel with a prominent entrance, a clock tower, and the name "REIKART HOUSE" displayed above the entrance.

14. Reikart House, Buffalo, a Tribute Portfolio Hotel

Reikart House, Buffalo, a Tribute Portfolio Hotel
4.0 star property
8.3 km from Buffalo Museum of Science
9.6 out of 10, Exceptional, (755 reviews)
"Great stay"
United States
Jonathon
The price is ₩305,825
₩347,877 total
includes taxes & fees
Nov 15 - Nov 16
Reikart House, Buffalo, a Tribute Portfolio Hotel
Breakfast area

15. Hampton Inn Buffalo - Amherst, NY

Hampton Inn Buffalo - Amherst, NY
2.5 star property
10.6 km from Buffalo Museum of Science
9.4 out of 10, Exceptional, (2,085 reviews)
"The location is convenient for dining."
United States
Lee
The price is ₩149,704
₩170,289 total
includes taxes & fees
Nov 29 - Nov 30
Hampton Inn Buffalo - Amherst, NY
A patio area with outdoor seating, a barbecue grill, and a stone wall.

16. Tru by Hilton Williamsville Buffalo Airport

Tru by Hilton Williamsville Buffalo Airport
2.5 star property
13 km from Buffalo Museum of Science
9.0 out of 10, Wonderful, (1,002 reviews)
"Nice place convenient clean"
United States
Stephen P
The price is ₩149,704
₩170,288 total
includes taxes & fees
Nov 30 - Dec 1
Tru by Hilton Williamsville Buffalo Airport
A modern kitchen with a central island, wooden cabinets, and a bar area with stools.

17. Springhill Suites Buffalo Airport

Springhill Suites Buffalo Airport
2.5 star property
13 km from Buffalo Museum of Science
9.0 out of 10, Wonderful, (946 reviews)
"All around nice experience at this hotel with a decent breakfast and good coffee."
United States
Matthias
The price is ₩195,373
₩222,237 total
includes taxes & fees
Dec 7 - Dec 8
Springhill Suites Buffalo Airport
A modern hotel room with a large window, a sofa, a coffee table, and a TV.

18. Buffalo Marriott at LECOM HARBORCENTER

Buffalo Marriott at LECOM HARBORCENTER
3.5 star property
Downtown Buffalo, 4.4 km from Buffalo Museum of Science
9.4 out of 10, Exceptional, (991 reviews)
"Great stay"
United States
Stephen
The price is ₩323,779
₩378,012 total
includes taxes & fees
Nov 19 - Nov 20
Buffalo Marriott at LECOM HARBORCENTER
A parking lot with cars and a covered walkway.

19. Hyatt Place Buffalo/Amherst

Hyatt Place Buffalo/Amherst
3.0 star property
8.4 km from Buffalo Museum of Science
9.0 out of 10, Wonderful, (1,157 reviews)
"Great location"
United States
Gifford
The price is ₩195,373
₩222,238 total
includes taxes & fees
Nov 16 - Nov 17
Hyatt Place Buffalo/Amherst
A hotel pool area with a hot tub, lounge chairs, and a seating area with tables.

20. Courtyard Buffalo Airport

Courtyard Buffalo Airport
3.0 star property
9.6 km from Buffalo Museum of Science
9.0 out of 10, Wonderful, (1,001 reviews)
"Clean room, nice fitness room, convenient airport shuttle, staff exceptionally helpful and accommodating. Will stay here again."
United States
Tracy
The price is ₩213,531
₩249,296 total
includes taxes & fees
Nov 15 - Nov 16
Courtyard Buffalo Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels close to Buffalo Museum of Science

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
A grand staircase with ornate woodwork and a chandelier, leading to a room with a large wooden door and a stained glass window.
InnBuffalo off Elmwood
2.5 star property
10.0
Exceptional
225 reviews
View
A spacious room with a wooden floor, a fireplace, a dining table, and several chairs.
Buffalo Harmony House
4.5 star property
10.0
Exceptional
58 reviews
View
A spacious dining area with a long table, multiple chairs, a chandelier, and a fireplace.
The Edward Hotel
3.0 star property
9.6
Exceptional
270 reviews
View
A two-story building with a white exterior, a red door, and large windows.
Buffalo Guesthouse
4.0 star property
9.4
Exceptional
231 reviews
View
A grand entrance with a staircase leading to a door, surrounded by lush greenery and a well-maintained garden.
The Mansion On Delaware Ave
4.0 star property
9.4
Exceptional
1,003 reviews
View

Hotels recommended for families near Buffalo Museum of Science

A spacious lobby with a large sofa, a coffee table, and potted plants. There is a decorative wall with a painting and a large window providing natural light.

Wyndham Garden Buffalo Downtown

Wyndham Garden Buffalo Downtown
3.0 star property
Downtown Buffalo
9.0 out of 10, Wonderful, (1,897)
The price is ₩207,729
₩242,524 total
includes taxes & fees
Nov 9 - Nov 10
Wyndham Garden Buffalo Downtown

Other attractions near Buffalo Museum of Science

Buffalo Central Terminal

You can find out about the history of Buffalo when you stop by Buffalo Central Terminal. Experience the entertainment choices and great live music in this vibrant area.
See properties

Top Buffalo Museum of Science Hotel Reviews

A grand staircase with ornate woodwork and a chandelier, leading to a room with a large wooden door and a stained glass window.
InnBuffalo off Elmwood

InnBuffalo off Elmwood

InnBuffalo off Elmwood
Elmwood Village

10/10 Excellent

This property surpassed our expectations. Very comfortable and clean. Everything we needed was available. The available snacks and drinks were a fantastic touch. The house has been preserved beautifully. The outside yard/patio space and front porch were covered and perfect for relaxing. By far one of my favorite stays amongst my travels. Highly recommend.
United States
Lerran
Reviewed August 8, 2026
InnBuffalo off Elmwood

Frequently Asked Questions

What's the area like around Buffalo Museum of Science?

Buffalo Museum of Science is located in a historic area of Buffalo known for its great live music scene. If you're looking for a convenient place to stay, check out the 14 hotels and other accommodations you'll find within a mile.

What's the best hotel to stay near Buffalo Museum of Science?

Wyndham Garden Buffalo Downtown is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and a 24-hour fitness center. It's located 1.2 mi (1.9 km) from Buffalo Museum of Science. Other good choices within 5 miles include Hyatt Regency Buffalo / Hotel and Conference Center and Buffalo Guesthouse.

How many hotels will I be able to find close to Buffalo Museum of Science?

Expedia has 14 hotels and other accommodations within a mile from Buffalo Museum of Science.

If I need to cancel the hotel reservation for my stay near Buffalo Museum of Science, will I receive a refund?

Yes, most hotel room reservations are refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and receive a refund within 24 hours of your booking. Plug in your dates, click on "Search", then filter by "fully refundable" to review the top deals on offer near Buffalo Museum of Science.

Where can I learn more about changing or cancelling my trip in the area near Buffalo Museum of Science?

For more information about picking new dates or cancelling your stay near Buffalo Museum of Science, go to https://www.expedia.com/service/.

What can I see and do near Buffalo Museum of Science?

Study the collections at Buffalo AKG Art Museum, Buffalo History Museum, or Buffalo and Erie County Naval and Military Park. Some landmarks that you won't want to miss include Buffalo Central Terminal, Statler Tower, and Richardson Olmsted Complex. You can watch performances at Kleinhans Music Hall, Town Ballroom, and Road Less Traveled Productions if you're interested in local theater.