Find hotels in Cairo, IL from ₩72,012

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Go beyond your typical stay in Cairo

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Check prices for these dates

Tonight
Nov 13 - Nov 14
Tomorrow
Nov 14 - Nov 15
This weekend
Nov 13 - Nov 15
Next weekend
Nov 20 - Nov 22

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Our top choices for Cairo hotels

A hotel lobby with a reception desk, two armchairs, a coffee table, and large windows with potted plants.

1. Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.4 out of 10, (297 reviews)
"Good service,nice stuff and no complaints"
United States
Santiago
The price is ₩93,615
₩103,894 total
includes taxes & fees
Dec 11 - Dec 12
Quality Inn Cairo I-57
A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.

2. Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.8 out of 10, (686 reviews)
"Friendly helpful check in, room was comfortable. we were travelling with our dog and it has a large area to walk him around. excellent Mexican restaurant next door we would definitely stay again"
Canada
Judith
The price is ₩78,213
₩87,588 total
includes taxes & fees
Dec 1 - Dec 2
Super 8 by Wyndham Charleston/Sikeston East MO
A reception desk with a computer, a framed picture on the wall, and a vase with flowers.

3. La Center Motel

La Center Motel
2.0 star property
La Center
8.0 out of 10, Very good, (25 reviews)
"Property is located just outside of town, so very convenient yet slightly off the beaten path."
United States
Carrie
The price is ₩72,012
₩84,241 total
includes taxes & fees
Nov 14 - Nov 15
La Center Motel
A hotel room with two beds, a nightstand, a lamp, and a window with curtains.

4. Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
Charleston
6.6 out of 10, (107 reviews)
"Great"
United States
Jackson
The price is ₩88,001
₩98,536 total
includes taxes & fees
Nov 27 - Nov 28
Eagle Inn Charleston
A building with a fountain and flower beds in front.

5. The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
2.5 star property
Charleston
6.8 out of 10, (443 reviews)
"Everything was great clean helpful Everything friendly."
United States
Kathleen
The price is ₩88,668
₩99,270 total
includes taxes & fees
Nov 21 - Nov 22
The Riverstone Hotel Charleston-Sikeston
A modern kitchen with white cabinetry, stainless steel appliances, and a window with a view of greenery.

6. Quiet Country Stay: Modern Home Near Paducah

Quiet Country Stay: Modern Home Near Paducah
3.0 star property
Cunningham
The price is ₩198,699
₩387,370 total
includes taxes & fees
Dec 11 - Dec 12
Quiet Country Stay: Modern Home Near Paducah
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Cairo attractions

Fort Defiance State Park

7.4/10 (15 reviews)
Where the mighty Mississippi and Ohio rivers converge, Fort Defiance Park offers a rare view of this natural phenomenon. Explore the historic grounds where Lewis and Clark once trained the Corps of Discovery in 1803.
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Learn more about Cairo

At the confluence of the Mississippi and Ohio rivers, explore Cairo's historic Fort Defiance Park with its sweeping water views. History buffs shouldn't miss the Custom House Museum, where you can discover artifacts from this once-thriving river port town.

See all hotels in Cairo
A steel bridge with a sunset in the background.

Frequently Asked Questions

If I need to cancel my hotel reservation in Cairo, will I receive a refund?

Yes! Most hotel room reservations are refundable if you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, you may still be able to cancel and receive a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in Cairo.

Where can I learn more about changing or cancelling my trip to Cairo?

For more information about updating your trip to Cairo or cancelling it, head over to our customer service page.

Where is the best hotel to stay close to Fort Defiance?

Quality Inn Cairo I-57 is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and free parking. It's located 4.9 mi (7.8 km) from Fort Defiance. Other good options around the area include Victorian Splendor in So. Illinois: wallmanor.com and Eagle Inn Charleston.

What's the best hotel for staying near Barkley Regional Airport (PAH)?

Drury Inn & Suites Paducah is one of the top choices for your stay and is a popular 3-star hotel featuring free breakfast and an indoor pool. It's located 4.7 mi (7.6 km) from Barkley Regional Airport. Other choices close to the airport include La Quinta Inn & Suites by Wyndham Paducah and Baymont by Wyndham Paducah.

What is staying in Cairo like?

Visitors can enjoy all that Cairo has to offer including the restaurants, entertainment choices, and riverfront. This city also attracts tourists with its small-town vibe. There are 29 hotels and other accommodations in the surrounding area. Find out more about Cairo.

What should I see while I'm in Cairo?

The picturesque setting of Mississippi River and Ohio River Valley exemplify the area's natural beauty. Additionally, you might want to add Fort Defiance State Park to your itinerary. Check out what more to see and do in Expedia's Cairo guide.

What's the seasonal weather like in Cairo?

The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Cairo is 61 inches.

Where is the best place for a stay in Cairo?

Based on our traveler data, Quality Inn Cairo I-57 is one of the top choices for your stay. This hotel offers free breakfast and free parking. Other good choices for your trip to the area are Super 8 by Wyndham Charleston/Sikeston East MO and The Riverstone Hotel Charleston-Sikeston. See all available top hotels, or vacation rentals in Cairo.