Find Pet-friendly Hotels in Cape Girardeau, MO

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Check prices for these dates

Tonight
Nov 12 - Nov 13
Tomorrow
Nov 13 - Nov 14
This weekend
Nov 13 - Nov 15
Next weekend
Nov 20 - Nov 22

Our top choices for Cape Girardeau pet-friendly hotels

A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.

1. Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1,002 reviews)
"Easy check in and room was very clean. The food for breakfast and dinner is the bomb."
United States
Melody
The price is ₩133,573
₩150,689 total
includes taxes & fees
Nov 15 - Nov 16
Drury Plaza Hotel Cape Girardeau Conference Center
A spacious dining area with high ceilings, large windows, and modern lighting fixtures.

2. Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (860 reviews)
"Staff was friendly and helpful. Rooms and facilities were clean."
United States
Britney
The price is ₩130,353
₩147,056 total
includes taxes & fees
Nov 22 - Nov 23
Hampton Inn Cape Girardeau I 55 East
A hotel room with a large bed, two bedside tables, a desk with a chair, and two lamps.

3. Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1,000 reviews)
"Clean, spacious suite, enjoyable kick back and breakfast!"
United States
Mary
The price is ₩120,214
₩135,619 total
includes taxes & fees
Nov 22 - Nov 23
Drury Inn & Suites Cape Girardeau
A Dear Tree Inn building with a covered entrance and a clear sky at dusk.

4. Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
2.5 star property
Cape Girardeau
9.2 out of 10, Wonderful, (1,001 reviews)
"The lady's that works there are wonderful, and of course the breakfast was amazing!!"
United States
Livia
The price is ₩96,169
₩108,491 total
includes taxes & fees
Nov 22 - Nov 23
Pear Tree Inn Cape Girardeau West
A modern lounge area with seating options including sofas, chairs, and a hanging chair, with large windows providing a view of the outdoors.

5. Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (201 reviews)
"Had a great stay friendly staff very clean facilities!"
United States
Shannon
The price is ₩113,922
₩129,659 total
includes taxes & fees
Nov 19 - Nov 20
Tru By Hilton Cape Girardeau
A hotel room with a kitchenette, a bed, a desk, and a TV.

6. Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
2.5 star property
Cape Girardeau
8.0 out of 10, Very good, (1,000 reviews)
"Nice clean room"
United States
James
The price is ₩94,846
₩114,347 total
includes taxes & fees
Nov 22 - Nov 23
Candlewood Suites Cape Girardeau by IHG
A motel with multiple floors, a parking lot, and a staircase leading to the upper floors.

7. Town House Inn Cape Giradreau

Town House Inn Cape Giradreau
2.5 star property
Cape Girardeau
6.2 out of 10, (244 reviews)
"Room was clean, bed was comfortable, staff was friendly, parking was easy. It was an older hotel and could use some renovation but would definitely stay again."
United States
Jaime
The price is ₩93,510
₩109,233 total
includes taxes & fees
Nov 14 - Nov 15
Town House Inn Cape Giradreau
A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.

8. Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
3.0 star property
Jackson
9.6 out of 10, Exceptional, (1,000 reviews)
"The hotel was clean, comfortable and the breakfast was good."
United States
Leonardo
The price is ₩106,855
₩112,972 total
includes taxes & fees
Nov 22 - Nov 23
Drury Inn & Suites Jackson MO
A brick building with a sign reading "Mercantile & Hotel".

9. EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
3.0 star property
Marble Hill
9.4 out of 10, Exceptional, (118 reviews)
"Awesome hotel and staff was first rate, everything was fantastic. If you are in the area, stay at this hotel and eat in!!"
United States
Jan
The price is ₩140,449
₩152,877 total
includes taxes & fees
Nov 15 - Nov 16
EC Reed's Mercantile and Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Cape Girardeau Hotel Reviews

A spacious dining area with high ceilings, large windows, and modern lighting fixtures.
Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
Cape Girardeau

10/10 Excellent

Staff was friendly and helpful. Rooms and facilities were clean.
United States
Britney
Reviewed November 9, 2026
Hampton Inn Cape Girardeau I 55 East

Frequently Asked Questions

How many hotels that welcome pets are there in Cape Girardeau?

Stay with your furry friend at one of Expedia's 7 Cape Girardeau accommodations that accept pets.

What's the best time of year to travel to Cape Girardeau with my pet?

When you travel with your pet, keeping track of the weather can make the trip safe and fun for everyone. The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 40°F. Average annual precipitation for Cape Girardeau is 59 inches.

What is there to see and do with your pet in Cape Girardeau?

Known for its riverfront and university life, Cape Girardeau has lots to offer visitors. See the local sights and visit Century Casino & Hotel Cape Girardeau and Show Me Center. While you're there, make sure you don't miss Hunter Valley Winery and Trail of Tears State Park.

What's the best pet-friendly accommodation in Cape Girardeau?

Drury Plaza Hotel Cape Girardeau Conference Center is a top hotel for people traveling with their pets, and offers a restaurant and free WiFi for its human guests. Other good choices to stay with your pet include Candlewood Suites Cape Girardeau by IHG and Pear Tree Inn Cape Girardeau West.