Booking a rental car for your escape to Orange is easy with Expedia. About 5 kilometers from UC Irvine Medical Center, Enterprise is one of multiple car rental companies that are close by. Also check out the offers at National Car Rental and Alamo. Even if you want a car today, you can key in your pick-up and drop-off locations to view amazing deals from a wide range of suppliers. Select the one that suits you best, or check the “Great Deal” filter for more exclusive prices.