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Compare 310 hotels in Santa Cruz with room rates, reviews, and availability. Most hotels are fully refundable.

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 star property
Santa Cruz
9.0 out of 10, Wonderful, (346)
"Wonderful staff with beautiful pool area and amenities. Great restaurant too."
Canada
Jay
The price is ₩192,418
₩192,418 total
Jan 9 - Jan 10, 2026
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Marriott Santa Cruz de la Sierra Hotel

5.0 star property
Santa Cruz
9.0 out of 10, Wonderful, (210)
"Great hotel, food and location albeit a little expensive "
United States
Reinaldo
The price is ₩163,335
₩163,335 total
Dec 19 - Dec 20
Marriott Santa Cruz de la Sierra Hotel

Ibis Santa Cruz DE LA Sierra

3.0 star property
Santa Cruz
9.6 out of 10, Exceptional, (73)
"Great Spot"
United States
Jose
The price is ₩56,210
₩56,210 total
Dec 23 - Dec 24
Ibis Santa Cruz DE LA Sierra

Camino Real Hotel

4.5 star property
Santa Cruz
8.8 out of 10, Excellent, (407)
"The parrots. Unique"
United States
Juan P
The price is ₩264,979
₩264,979 total
Jan 4 - Jan 5, 2026
Camino Real Hotel

Sun Hotel

3.5 star property
Santa Cruz
8.4 out of 10, Very Good, (329)
"Staff spoke English. Airport pickup beat any US hotel. Rooms nice. Restaurant was ok"
United States
Peter
The price is ₩131,667
₩131,667 total
Dec 13 - Dec 14
Sun Hotel

Hotel Cortez

3.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (122)
"The staff and property are second to none! "
United States
Cynthia
The price is ₩185,599
₩185,599 total
Dec 23 - Dec 24
Hotel Cortez

HOTEL OSHO

3.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (34)
"Hot tub worked well and room was very comfortable! 24 hr market across the street came in handy. The best hotel I've stayed at in Bolivia!"
United States
Robert
The price is ₩73,765
₩73,765 total
Dec 10 - Dec 11
HOTEL OSHO

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

4.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (253)
"Nice hotel "
United States
Narciso Lorenzo
The price is ₩94,006
₩94,006 total
Jan 8 - Jan 9, 2026
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

Apart Hotel Premium Suites Santa Cruz

3.5 star property
Santa Cruz
8.6 out of 10, Excellent, (93)
"Come and go easily, intellectual and kind owners who are working hard to make the property improvements that will bring this hotel up to the next level. A family friendly environment with easy walking distance to everything you need. Bed was not the best, but I know they are upgrading so I appreciate the ongoing process. For a few nights stay, the deals are very fair prices. "
United States
Andrew
Apart Hotel Premium Suites Santa Cruz

Novotel Santa Cruz De La Sierra

5.0 star property
Santa Cruz
9.2 out of 10, Wonderful, (103)
"Great location and very clean hotel. Will stay again soon."
United States
William
The price is ₩146,884
₩146,884 total
Jan 7 - Jan 8, 2026
Novotel Santa Cruz De La Sierra

TRYP by Wyndham Santa Cruz

4.0 star property
Santa Cruz
9.2 out of 10, Wonderful, (145)
"Nice stay with good service "
United States
Jianyuan
The price is ₩145,415
₩145,415 total
Dec 11 - Dec 12
TRYP by Wyndham Santa Cruz

Chairú Eco Hotel

3.5 star property
Santa Cruz
9.6 out of 10, Exceptional, (47)
"Nice property. Would definitely stay there again and again. Only negative was on our last night there was a really noisy party next door that lasted until 2am. "
United States
Andrew
Chairú Eco Hotel

Premium Suites Deluxe Aparthotel Equipetrol

3.5 star property
Santa Cruz
9.0 out of 10, Wonderful, (81)
"Good price, great hotel!"
United States
James
The price is ₩57,285
₩57,285 total
Jan 6 - Jan 7, 2026
Premium Suites Deluxe Aparthotel Equipetrol

Delfines Collection Hotel By Mercure

3.5 star property
Santa Cruz
9.0 out of 10, Wonderful, (71)
"Clean comfortable rooms "
United States
mary
The price is ₩62,176
₩62,176 total
Dec 19 - Dec 20
Delfines Collection Hotel By Mercure

Swissôtel Santa Cruz De La Sierra

4.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (81)
"Beautiful hotel"
Australia
Joanna
The price is ₩217,388
₩217,388 total
Jan 1 - Jan 2, 2026
Swissôtel Santa Cruz De La Sierra

Lido Hotel

3.0 star property
Santa Cruz
9.0 out of 10, Wonderful, (30)
"Very helpful and nice staff. Quiet location. near the central plaza. Great value "
United Kingdom
David
The price is ₩67,467
₩67,467 total
Dec 14 - Dec 15
Lido Hotel

Alfonsina Hotel Boutique by Inboccaluppo

3.5 star property
Santa Cruz
9.4 out of 10, Exceptional, (40)
"Love it. Will stay again!!"
United States
Juan
The price is ₩155,634
₩155,634 total
Jan 8 - Jan 9, 2026
Alfonsina Hotel Boutique by Inboccaluppo

Hotel LP Santa Cruz Centro

3.0 star property
Santa Cruz
8.0 out of 10, Very Good, (280)
"Clean, friendly staff"
United States
Giovanna
Hotel LP Santa Cruz Centro

Hotel LP Equipetrol

3.5 star property
Santa Cruz
8.2 out of 10, Very Good, (201)
"Nice place to stay"
United States
Ricardo
Hotel LP Equipetrol

Hotel Las Américas

3.0 star property
Santa Cruz
6.0 out of 10, (1)
"O chuveiro foi impossível tomar um.banho de qualidade "
Brazil
Jean
The price is ₩56,448
₩56,448 total
Dec 11 - Dec 12
Hotel Las Américas
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Top Santa Cruz Hotel Reviews

Frequently asked questions

How much do hotels in Santa Cruz cost?
The season and factors like school holidays, Christmas and Easter can influence the price of a hotel in Santa Cruz. You can find cheap options from ₩56,210 in a few different ways on Expedia. First, key in the dates you'd like to go on vacation, then use the filters such as property type and amenities to refine your search. You can also sort by price, so the most inexpensive options appear at the top.
When is the best time to go to Santa Cruz?
If you're thinking of visiting in summer, reserve your Santa Cruz hotel between December and February. Temperatures during the summer here range from 22ºC to 31ºC. Santa Cruz has an oceanic climate, so pack appropriately.
Are there any luxury hotels in Santa Cruz?
Expedia has got some terrific stays for an indulgent escape in Santa Cruz, Santa Cruz, such as Hampton by Hilton Santa Cruz/Equipetrol, Bolivia. Check in and make use of amenities like concierge services, a garden and complimentary breakfast. Alternatively, treat yourself at Radisson Hotel Santa Cruz.
What are the top all-inclusive hotels in Santa Cruz?
If you're looking for a relaxed and worry-free escape, throw your bags down at Prince Hotel. Generally including your drinks, food and some recreational activities in the flat upfront rate, it's one of the best options for an all-inclusive retreat in Santa Cruz.
How can I find cheap hotels in Santa Cruz?
Discover inexpensive hotels with minimal effort by making use of our filter tool. Choose the "Price per night" box to view low-cost options in Santa Cruz. Another way is to take a look at our cheap hotels in Santa Cruz page. The lowest price available starts from ₩56,210 per night.
What are the best hotels in Santa Cruz for families?
Cosmopolitano Hotel Boutique is one of the top-rated hotels for families, located in Santa Cruz, Santa Cruz. Book here and take advantage of conveniences such as complimentary breakfast and a cafe. Hampton by Hilton Santa Cruz/Equipetrol, Bolivia is another favorite where kiddos are welcome. For more hotel options, fine-tune your search results by selecting "Family friendly" under the "Traveler experience" filter heading.
Why should I book my Santa Cruz hotel with Expedia?
Book your Santa Cruz hotel with Expedia and enjoy a world of options at unbeatable prices. Use our search filters to help you find exactly what you want, whether that's a 5-star escape or something a little more unique, like a houseboat, log cabin or villa! Join Expedia Rewards and you'll save 10% or more on over 100,000 hotels worldwide when you're signed in. Collect points on eligible bookings, which you can use to save on your next epic adventure. Plus, many of our hotels come with flexible cancellation policies, so you can rest easy if your plans happen to change.