The Best Resorts & Hotels with Spas in Hannibal, MO from ₩133,062 in 2026

A river with a bridge, a town, and a forested hillside.

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Our top choices for Hannibal hotels with a spa

In-room safe, desk, blackout drapes, iron/ironing board

1. Comfort Inn & Suites - Hannibal

Hannibal

Serene spa sanctuary awaits in the heart of Hannibal with rejuvenating hot tub, indoor pool, and hydromassage showers.

₩111,760

₩133,062 total

includes taxes & fees

Sep 20 - Sep 21

Suite, 1 King Bed with Sofa bed, Jetted Tub | Premium bedding, pillowtop beds, in-room safe, desk

2. Holiday Inn Quincy East by IHG

Quincy

Revitalizing spa treatments await at this hotel, where an indoor pool, cozy pillow menus, and attentive staff create a relaxing retreat.

₩168,976

₩192,599 total

includes taxes & fees

Sep 27 - Sep 28

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Choose what matters most at spa hotels in Hannibal

Pool

Breakfast included

Hot tub

4 stars

5 stars

Top Hannibal Hotel Reviews

Microtel Inn & Suites by Wyndham Quincy Downtown/River Area

8/10 Good

"The stay was good/very good. The breakfast was very nice and the Breakfast worker was VERY EFFICIENT. Bridget who I checked in with was good. The view of the river and two bridges was really nice too. My ONLY issue with the stay was I booked on hotels.com CLEARLY a room with two queens and one king bed. I even showed Brigit the worker at the front desk that was how I booked it and where it said that on the hotel page. She claimed there were NO ROOMS like that despite the website CLEARLY having me pay for 2 queens and 1 king. It forced me to sleep on the window ledge which clearly was not comfortable at all. I had a NON-REFUNDABLE reservation so nothing could be done despite being fraudulently advertised. I don’t know if that is on Microtel or the manager, but that is not right. The other 7 days of our vacation, we ALWAYS had 2 queens and a pullout king and that is what I paid for, expected, but did NOT get."

Stoney Creek Inn Quincy

10/10 Excellent

"Nice large room & very clean."

Quality Inn & Suites Hannibal West

10/10 Excellent

"Excellent service, I enjoyed, especially the free Breakfast"

Frequently asked questions

Looking to vacation at a spa hotel in Hannibal?

Forget the stress of everyday life and book yourself a hotel with a spa. Travelers recommend the gourmet restaurants in Hannibal. Enjoy the shopping and riverfront during your vacation. Spa hotels are a great way to break out of your routine and add a layer of luxury to your vacation.

What is the best spa hotel in Hannibal?

Comfort Inn & Suites - Hannibal is a top spa hotel featuring a 24-hour fitness center and an indoor pool. Kick back and relax in the hot tub.

How many spa hotels are there in Hannibal?

Among Expedia's 53 accommodation options in Hannibal, there is 1 spa hotel.

What's there to see and do in Hannibal?

Take in the sights and attractions that Hannibal offers with a visit to Rockcliffe Mansion, Big River Train Town, and Mark Twain Boyhood Home and Museum. If you have a little extra time during your trip, you might want to check out Lovers Leap and Mark Twain Cave.

What is a Hannibal spa hotel?

Spa hotels in Hannibal provide lodging and have an on-site spa offering services such as couples massages and beauty treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation, and relaxation.

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