La Mesa Vacation Rentals

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
Jan 9 - Jan 11
In two months
Feb 20 - Feb 22
In three months
Mar 20 - Mar 22
In four months
Apr 17 - Apr 19

Our top choices for La Mesa vacation rentals

Apartment, 1 Bedroom, Balcony | Property grounds
Swette Love 10 Minutes From the Airport Tocumen

Swette Love 10 Minutes From the Airport Tocumen

Swette Love 10 Minutes From the Airport Tocumen
2.0 star property
Las Mañanitas
The price is ₩110,556
₩138,621 total
includes taxes & fees
Jan 7 - Jan 8, 2026
Swette Love 10 Minutes From the Airport Tocumen
50-inch LED TV with satellite channels
Arcadia Condo Suites

Arcadia Condo Suites

Arcadia Condo Suites
2.5 star property
Costa del Este
9.4 out of 10, Exceptional, (170)
"Was a great buy. Beautiful views and spacious rooms. Great amenities. "
United States
Lesley
The price is ₩119,566
₩198,237 total
includes taxes & fees
Jan 25 - Jan 26, 2026
Arcadia Condo Suites
Apartment | 2 bedrooms
Relaxing 2BR Apt at Coco del mar

Relaxing 2BR Apt at Coco del mar

Relaxing 2BR Apt at Coco del mar
2.0 star property
San Francisco
The price is ₩363,485
₩399,834 total
includes taxes & fees
Jan 13 - Jan 14, 2026
Relaxing 2BR Apt at Coco del mar
Outdoor pool
Boutique Apartments Atlapa

Boutique Apartments Atlapa

Boutique Apartments Atlapa
3.0 star property
San Francisco
8.0 out of 10, Very Good, (28)
"I had an excellent stay here ! It was a very amazing the host is an amazing person thank you for making My stay great❤️"
United States
Shamia
Boutique Apartments Atlapa
Lobby sitting area
San Francisco by Wynwood House

San Francisco by Wynwood House

San Francisco by Wynwood House
3.0 star property
San Francisco
9.2 out of 10, Wonderful, (56)
"Clean and walkable location"
United States
Tamera
The price is ₩175,876
₩229,674 total
includes taxes & fees
Jan 4 - Jan 5, 2026
San Francisco by Wynwood House
Living area
Living 73 Panamá by Boutique Apartments

Living 73 Panamá by Boutique Apartments

Living 73 Panamá by Boutique Apartments
3.0 star property
San Francisco
The price is ₩55,427
₩273,346 total
includes taxes & fees
Jan 10 - Jan 11, 2026
Living 73 Panamá by Boutique Apartments
Apartment, 3 Bedrooms, Accessible, Pool View | Children's area
Charming 3 Bedroom Apartment in San Miguelito, Panama City

Charming 3 Bedroom Apartment in San Miguelito, Panama City

Charming 3 Bedroom Apartment in San Miguelito, Panama City
2.0 star property
José Domingo Espinar
The price is ₩104,093
₩114,502 total
includes taxes & fees
Jan 7 - Jan 8, 2026
Charming 3 Bedroom Apartment in San Miguelito, Panama City
Apartment | 2 bedrooms
Brand New 2BR apt w Gym and Pool

Brand New 2BR apt w Gym and Pool

Brand New 2BR apt w Gym and Pool
2.0 star property
San Francisco
The price is ₩363,485
₩449,543 total
includes taxes & fees
Jan 8 - Jan 9, 2026
Brand New 2BR apt w Gym and Pool
Apartment | 2 bedrooms
Comfortable 2BR City Apartment

Comfortable 2BR City Apartment

Comfortable 2BR City Apartment
2.0 star property
San Francisco
The price is ₩363,485
₩399,834 total
includes taxes & fees
Jan 8 - Jan 9, 2026
Comfortable 2BR City Apartment
Apartment | 2 bedrooms
Lovely 2BR Apt Close to Shops

Lovely 2BR Apt Close to Shops

Lovely 2BR Apt Close to Shops
2.0 star property
San Francisco
The price is ₩363,485
₩399,834 total
includes taxes & fees
Jan 13 - Jan 14, 2026
Lovely 2BR Apt Close to Shops
Apartment | 1 bedroom
Dovle 510 in Ciudad de Panam

Dovle 510 in Ciudad de Panam

Dovle 510 in Ciudad de Panam
2.0 star property
San Francisco
The price is ₩314,358
₩345,794 total
includes taxes & fees
Jan 9 - Jan 10, 2026
Dovle 510 in Ciudad de Panam
Apartment | 2 bedrooms
Stylish 2BR Apt Near the Park Omar

Stylish 2BR Apt Near the Park Omar

Stylish 2BR Apt Near the Park Omar
2.0 star property
San Francisco
The price is ₩294,725
₩373,907 total
includes taxes & fees
Jan 13 - Jan 14, 2026
Stylish 2BR Apt Near the Park Omar
Apartment | 2 bedrooms
Urban 2BR Apt in Central Area

Urban 2BR Apt in Central Area

Urban 2BR Apt in Central Area
2.0 star property
San Francisco
The price is ₩294,725
₩324,198 total
includes taxes & fees
Jan 8 - Jan 9, 2026
Urban 2BR Apt in Central Area
Apartment | 1 bedroom
Elegant Loft Pool Gym and Workspaces

Elegant Loft Pool Gym and Workspaces

Elegant Loft Pool Gym and Workspaces
2.0 star property
San Francisco
The price is ₩314,358
₩395,503 total
includes taxes & fees
Jan 10 - Jan 11, 2026
Elegant Loft Pool Gym and Workspaces
Apartment | 2 bedrooms
Cozy 2BR Close to Panama Old Town

Cozy 2BR Close to Panama Old Town

Cozy 2BR Close to Panama Old Town
2.0 star property
San Francisco
Cozy 2BR Close to Panama Old Town
Apartment | 2 bedrooms
Spacious 2BR w Terrace Lounge

Spacious 2BR w Terrace Lounge

Spacious 2BR w Terrace Lounge
2.0 star property
San Francisco
The price is ₩294,725
₩415,331 total
includes taxes & fees
Jan 13 - Jan 14, 2026
Spacious 2BR w Terrace Lounge
Apartment | 1 bedroom
Two-level Apt by Panama old Town

Two-level Apt by Panama old Town

Two-level Apt by Panama old Town
2.0 star property
San Francisco
Two-level Apt by Panama old Town
Apartment | 1 bedroom
Dovle 509 in Ciudad de Panam

Dovle 509 in Ciudad de Panam

Dovle 509 in Ciudad de Panam
2.0 star property
San Francisco
The price is ₩314,358
₩345,794 total
includes taxes & fees
Jan 8 - Jan 9, 2026
Dovle 509 in Ciudad de Panam
Apartment | 1 bedroom
Smart Loft-style 1BR Apt Near to Shops

Smart Loft-style 1BR Apt Near to Shops

Smart Loft-style 1BR Apt Near to Shops
2.0 star property
San Francisco
The price is ₩314,358
₩345,794 total
includes taxes & fees
Jan 8 - Jan 9, 2026
Smart Loft-style 1BR Apt Near to Shops
Apartment | 1 bedroom
4 Guests 1 Bedroom Shared Pool

4 Guests 1 Bedroom Shared Pool

4 Guests 1 Bedroom Shared Pool
2.0 star property
San Francisco
4 Guests 1 Bedroom Shared Pool
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top La Mesa Hotel Reviews

Courtyard by Marriott Panama Metromall

Courtyard by Marriott Panama Metromall

10/10 Excellent
"It was clean and nice. "
Gabriel 1-night trip
Posted 22 hours ago
Courtyard by Marriott Panama Metromall

Find out more about La Mesa

Search for Vacation rentals in La Mesa on Expedia.co.uk! You can easily find your home rentals, villas, Vacation apartments in La Mesa using one of the methods below:

  • View our selection of featured Vacation rentals in La Mesa
  • Use the map to find apartments and other Vacation homes in the La Mesa neighbourhood you prefer
  • Enter your travel dates to view the best deals on Vacation rentals in La Mesa while they last

Look no further and take a look at our great range of rental properties in La Mesa!

Frequently asked questions

Are there vacation rentals in La Mesa?

Yes, we offer vacation rentals close to well known sights in La Mesa, or you can choose a more secluded option if you're looking for a relaxing stay.

What’s there to see and do in La Mesa?

While exploring the area, visit family-friendly sights like Chepo Youth Recreation Center, or get outside and enjoy nature at Chagres National Park. In the larger area, you’ll find Metromall Panama and Los Pueblos Commercial Center.

What’s a vacation rental in La Mesa like?

A vacation rental is a private property you can stay in for short or long periods in La Mesa. Vacation rentals feature amenities such as hot tubs, fire pits, and patios so your stay will be comfortable. If you're concerned about a sanitized environment, vacation rentals can offer a sense of security away from public hotel elevators and busy concierge desks while still allowing you the enjoyment of travel. You'll also get more space in a vacation rental than in a traditional hotel, which is another reason why a vacation rental is a popular option for family trips or small group gatherings.