Find hotels in Medicine Lake, Minneapolis - St. Paul

Start date: Check-in selected.
To Date
End date: Check-out
  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
In two weeks

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Medicine Lake hotels

Holiday Inn Express & Suites Mall of America - MSP Airport by IHG

Holiday Inn Express & Suites Mall of America - MSP Airport by IHG
2.5 star property
19.9 km from Medicine Lake
9.0 out of 10, Wonderful, (2887)
"Great place to stay!!! "
United States
Tamera
The price is ₩121,099
₩140,506 total
includes taxes & fees
Dec 30 - Dec 31
Holiday Inn Express & Suites Mall of America - MSP Airport by IHG

Hilton Garden Inn Minneapolis Airport Mall of America

Hilton Garden Inn Minneapolis Airport Mall of America
3.5 star property
20.3 km from Medicine Lake
8.4 out of 10, Very Good, (2186)
"Great staff great rooms "
United States
Mathew
The price is ₩104,564
₩121,319 total
includes taxes & fees
Jan 25 - Jan 26, 2026
Hilton Garden Inn Minneapolis Airport Mall of America

Hampton Inn & Suites Minneapolis University Area

Hampton Inn & Suites Minneapolis University Area
2.5 star property
16.3 km from Medicine Lake
9.4 out of 10, Exceptional, (1002)
"Everything was very efficient at check in, nice place"
United States
Michael
The price is ₩109,898
₩130,799 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Hampton Inn & Suites Minneapolis University Area

Baymont by Wyndham Bloomington MSP Airport

Baymont by Wyndham Bloomington MSP Airport
2.5 star property
19.8 km from Medicine Lake
8.0 out of 10, Very Good, (2096)
"Great stay and great hotel!"
United States
Dillon
The price is ₩91,906
₩102,959 total
includes taxes & fees
Jan 26 - Jan 27, 2026
Baymont by Wyndham Bloomington MSP Airport

Hilton Garden Inn Minneapolis Downtown

Hilton Garden Inn Minneapolis Downtown
3.5 star property
12.2 km from Medicine Lake
8.4 out of 10, Very Good, (1005)
"Everything was wonderful... just like the last time I stayed here. "
United States
Jessie
The price is ₩132,099
₩154,589 total
includes taxes & fees
Dec 29 - Dec 30
Hilton Garden Inn Minneapolis Downtown

The Westin Minneapolis

The Westin Minneapolis
4.0 star property
11.9 km from Medicine Lake
8.4 out of 10, Very Good, (1002)
"Always a great stay at the Westin! "
United States
gabby
The price is ₩157,141
₩183,895 total
includes taxes & fees
Dec 29 - Dec 30
The Westin Minneapolis

Hyatt Regency Bloomington - Minneapolis

Hyatt Regency Bloomington - Minneapolis
4.0 star property
21.9 km from Medicine Lake
9.0 out of 10, Wonderful, (2069)
"Clean room, great breakfast, convenient "
United States
Joanne
The price is ₩128,669
₩149,288 total
includes taxes & fees
Dec 30 - Dec 31
Hyatt Regency Bloomington - Minneapolis

The Marquette Hotel, Curio Collection by Hilton

The Marquette Hotel, Curio Collection by Hilton
4.0 star property
11.9 km from Medicine Lake
9.4 out of 10, Exceptional, (1004)
"Clean, helpful staff and location. "
United States
Sheena Martina
The price is ₩154,301
₩180,571 total
includes taxes & fees
Jan 6 - Jan 7, 2026
The Marquette Hotel, Curio Collection by Hilton

Hampton Inn & Suites Minneapolis / Downtown

Hampton Inn & Suites Minneapolis / Downtown
3.0 star property
11.5 km from Medicine Lake
9.4 out of 10, Exceptional, (1934)
"Courteous staff and great location. "
United States
Darren
The price is ₩109,898
₩128,608 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Hampton Inn & Suites Minneapolis / Downtown

The Lofton Hotel, Tapestry Collection by Hilton

The Lofton Hotel, Tapestry Collection by Hilton
4.5 star property
11.6 km from Medicine Lake
9.4 out of 10, Exceptional, (1001)
"Friendly staff, comfortable beds, beautiful views, great location "
United States
Julia
The price is ₩165,402
₩193,562 total
includes taxes & fees
Jan 9 - Jan 10, 2026
The Lofton Hotel, Tapestry Collection by Hilton

Fairfield Inn & Suites by Marriott Minneapolis Shakopee

Fairfield Inn & Suites by Marriott Minneapolis Shakopee
2.5 star property
24.1 km from Medicine Lake
9.0 out of 10, Wonderful, (764)
"The desk clerk was very friendly, polite and responsive. Love staying here."
United States
Craig
The price is ₩121,964
₩135,837 total
includes taxes & fees
Dec 30 - Dec 31
Fairfield Inn & Suites by Marriott Minneapolis Shakopee

Hilton Minneapolis

Hilton Minneapolis
4.0 star property
11.8 km from Medicine Lake
8.8 out of 10, Excellent, (1005)
"It was a nice stay "
Canada
Shannon
The price is ₩143,200
₩167,580 total
includes taxes & fees
Jan 26 - Jan 27, 2026
Hilton Minneapolis

Hyatt Place Minneapolis Downtown

Hyatt Place Minneapolis Downtown
3.0 star property
12.4 km from Medicine Lake
8.4 out of 10, Very Good, (2069)
"excellent fast check in, room is great. Very nice hotel"
Canada
Rob
The price is ₩142,724
₩167,024 total
includes taxes & fees
Jan 8 - Jan 9, 2026
Hyatt Place Minneapolis Downtown

InterContinental Saint Paul Riverfront by IHG

InterContinental Saint Paul Riverfront by IHG
4.0 star property
26.4 km from Medicine Lake
8.4 out of 10, Very Good, (1002)
"It was a very nice stay."
United States
Nathaniel
The price is ₩139,841
₩163,455 total
includes taxes & fees
Jan 11 - Jan 12, 2026
InterContinental Saint Paul Riverfront by IHG

Sheraton Minneapolis Downtown Convention Center

Sheraton Minneapolis Downtown Convention Center
3.5 star property
11.6 km from Medicine Lake
8.8 out of 10, Excellent, (120)
"Very nice rooms and convenient location "
United States
Tiffany
The price is ₩145,824
₩170,650 total
includes taxes & fees
Dec 30 - Dec 31
Sheraton Minneapolis Downtown Convention Center

Hilton Garden Inn Minneapolis - Maple Grove

Hilton Garden Inn Minneapolis - Maple Grove
3.0 star property
8.2 km from Medicine Lake
9.2 out of 10, Wonderful, (1004)
"Nice hotel, and nice options for activities in the area! "
United States
Jessica
The price is ₩120,999
₩135,549 total
includes taxes & fees
Jan 23 - Jan 24, 2026
Hilton Garden Inn Minneapolis - Maple Grove

Hyatt Centric Downtown Minneapolis

Hyatt Centric Downtown Minneapolis
4.5 star property
12.1 km from Medicine Lake
9.0 out of 10, Wonderful, (1003)
"The rooms are nice and the hotel is walkable to so many venues and restaurants in downtown. "
United States
Kamilla
The price is ₩141,283
₩165,336 total
includes taxes & fees
Jan 8 - Jan 9, 2026
Hyatt Centric Downtown Minneapolis

The Royal Sonesta Minneapolis Downtown

The Royal Sonesta Minneapolis Downtown
4.5 star property
11.7 km from Medicine Lake
9.0 out of 10, Wonderful, (1779)
"Beautiful hotel, great staff! "
United States
Katie
The price is ₩155,022
₩181,414 total
includes taxes & fees
Dec 30 - Dec 31
The Royal Sonesta Minneapolis Downtown

Hampton Inn by Hilton Minneapolis/Eagan

Hampton Inn by Hilton Minneapolis/Eagan
2.5 star property
26.7 km from Medicine Lake
8.8 out of 10, Excellent, (1007)
"Great staff…great place!"
United States
Mark
The price is ₩140,677
₩156,326 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Hampton Inn by Hilton Minneapolis/Eagan

Embassy Suites by Hilton Minneapolis Airport

Embassy Suites by Hilton Minneapolis Airport
4.0 star property
21.9 km from Medicine Lake
9.0 out of 10, Wonderful, (1867)
"Nice rooms and great breakfast!"
United States
Jose
The price is ₩149,861
₩173,876 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Embassy Suites by Hilton Minneapolis Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Medicine Lake

Find the best Medicine Lake areas and neighborhoods for the activities you enjoy most.

Downtown Minneapolis

Known for its fantastic nightlife and popular shops, there's plenty to explore in Downtown Minneapolis. Check out top attractions like Nicollet Mall and Foshay Tower, and jump on the metro at Nicollet Mall Station or Warehouse - Hennepin Station to see more of the city.

Downtown St. Paul

Spend some time visiting places like Fitzgerald Theater while getting to know Downtown St. Paul, and be sure to check out the live music. You can hop aboard the metro at 10th Street Station or Central Station to see more of the area.

South Minneapolis

If you're spending time in South Minneapolis, check out sights like Parkway Theater or Lake Nokomis and hop on the metro to see more the city at 38th Street Station or 46th Street Station.

Downtown West

Heart of downtown Minneapolis, Downtown West boasts high-rise office buildings and notable landmarks like Foshay Tower and IDS Center. A bustling urban hub for business and architecture enthusiasts.

South Loop

While you're in South Loop, take in top sights like Mall of America or Sea Life Minnesota Aquarium, and hop on the metro to see more the city at 28th Avenue Station or Mall of America Station.

Top Medicine Lake Hotel Reviews

Frequently asked questions

What is Medicine Lake like?
Travelers are sure to enjoy a stay in Plymouth's Medicine Lake neighborhood.
If I need to cancel my hotel reservation in Medicine Lake, will I receive a refund?
Yes, the majority of hotel room reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you booked a non-refundable reservation, you might still have the option to cancel and get a refund within 24 hours of booking. Enter dates in and click on "Search", then you can use the "fully refundable" filter to review top deals in Medicine Lake.
Where can I learn more about changing or cancelling my trip to Medicine Lake?
To access more information about picking new dates or cancelling your trip to Medicine Lake, head over to our customer service page.
What can I see and do in this Plymouth neighborhood?
A few places to visit in the area around Medicine Lake include French Park Beach, Sky Zone Indoor Trampoline Park, and Plymouth Playhouse. When you're sightseeing in Plymouth, Brookview Golf Course and Ridgedale Center are also worth a stop.