Find hotels near Odessa Regional Medical Center South Campus, Odessa from ₩99,623

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Dec 26 - Dec 27
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Dec 27 - Dec 28
This weekend
Dec 26 - Dec 28
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Jan 2 - Jan 4

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Our top choices for Odessa Regional Medical Center South Campus hotels

Outdoor pool, open 10:00 AM to 10:00 PM, cabanas (surcharge)
Odessa Marriott Hotel & Conference Center

Odessa Marriott Hotel & Conference Center

Odessa Marriott Hotel & Conference Center
4.0 star property
0.7 km from Odessa Regional Medical Center South Campus
9.2 out of 10, Wonderful, (466)
"Rooms and hotel were great"
United States
John
The price is ₩272,301
₩313,145 total
includes taxes & fees
Jan 9 - Jan 10, 2026
Odessa Marriott Hotel & Conference Center
Lobby
Motel 6 Odessa, TX - 2nd Street

Motel 6 Odessa, TX - 2nd Street

Motel 6 Odessa, TX - 2nd Street
2.0 star property
1.3 km from Odessa Regional Medical Center South Campus
7.8 out of 10, Good, (501)
"Clean, quiet and a good price. The management here is quat"
United States
Ronald
The price is ₩86,627
₩99,623 total
includes taxes & fees
Jan 26 - Jan 27, 2026
Motel 6 Odessa, TX - 2nd Street
Free breakfast
Holiday Inn Express & Suites Odessa I-20 by IHG

Holiday Inn Express & Suites Odessa I-20 by IHG

Holiday Inn Express & Suites Odessa I-20 by IHG
2.5 star property
3 km from Odessa Regional Medical Center South Campus
8.8 out of 10, Excellent, (470)
"Room was nicely cleaned & staff was very polite. "
United States
Mariano
The price is ₩143,393
₩166,568 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Holiday Inn Express & Suites Odessa I-20 by IHG
Desk, laptop workspace, blackout drapes, iron/ironing board
MainStay Suites Odessa I-20

MainStay Suites Odessa I-20

MainStay Suites Odessa I-20
2.5 star property
2.9 km from Odessa Regional Medical Center South Campus
8.2 out of 10, Very Good, (300)
"Very clean very spacious rooms friendly staff loved it"
United States
Jamayea
The price is ₩114,424
₩131,588 total
includes taxes & fees
Dec 27 - Dec 28
MainStay Suites Odessa I-20
Suite, 1 King Bed, Jetted Tub, Pool View (with Sofabed) | View from room
SureStay Plus Hotel by Best Western Odessa

SureStay Plus Hotel by Best Western Odessa

SureStay Plus Hotel by Best Western Odessa
3.0 star property
2.6 km from Odessa Regional Medical Center South Campus
7.4 out of 10, Good, (77)
"Very nice place to stay "
United States
Jerry
The price is ₩121,666
₩139,915 total
includes taxes & fees
Dec 27 - Dec 28
SureStay Plus Hotel by Best Western Odessa
Room, Non Smoking | Rollaway beds, free WiFi
Villa West Inn

Villa West Inn

Villa West Inn
2.0 star property
2.6 km from Odessa Regional Medical Center South Campus
7.4 out of 10, Good, (178)
"Clean room, clean toilet and good staffs."
United States
Francis
The price is ₩86,642
₩99,638 total
includes taxes & fees
Dec 29 - Dec 30
Villa West Inn
Living area
DELUX INN

DELUX INN

DELUX INN
2.5 star property
2.5 km from Odessa Regional Medical Center South Campus
6.8 out of 10, (24)
"Best hotel "
United States
Poncho
The price is ₩93,862
₩107,941 total
includes taxes & fees
Dec 29 - Dec 30
DELUX INN
Blackout drapes, free WiFi, bed sheets
Motel 6 Odessa, TX

Motel 6 Odessa, TX

Motel 6 Odessa, TX
2.0 star property
2.7 km from Odessa Regional Medical Center South Campus
6.8 out of 10, (553)
"The room was very clean. And management was very helpful."
United States
Bonnie
The price is ₩92,403
₩106,266 total
includes taxes & fees
Jan 26 - Jan 27, 2026
Motel 6 Odessa, TX
Children's area
Staybridge Suites Odessa - Interstate HWY 20 by IHG

Staybridge Suites Odessa - Interstate HWY 20 by IHG

Staybridge Suites Odessa - Interstate HWY 20 by IHG
3.0 star property
4 km from Odessa Regional Medical Center South Campus
8.8 out of 10, Excellent, (144)
"Excellent "
United States
Jeannette
The price is ₩114,424
₩131,587 total
includes taxes & fees
Dec 29 - Dec 30
Staybridge Suites Odessa - Interstate HWY 20 by IHG
Seasonal outdoor pool, open 7:00 AM to 10:00 PM, sun loungers
Hawthorn Extended Stay by Wyndham Odessa

Hawthorn Extended Stay by Wyndham Odessa

Hawthorn Extended Stay by Wyndham Odessa
3.5 star property
4.1 km from Odessa Regional Medical Center South Campus
8.6 out of 10, Excellent, (269)
"Clean room, reasonable price and restaurant on site which was perfect after a long day of driving"
United States
Kimberly
The price is ₩129,053
₩148,411 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Hawthorn Extended Stay by Wyndham Odessa
Property amenity
Candlewood Suites Odessa by IHG

Candlewood Suites Odessa by IHG

Candlewood Suites Odessa by IHG
2.5 star property
3.9 km from Odessa Regional Medical Center South Campus
8.6 out of 10, Excellent, (190)
"It was a smaller place than i have stayed before, it does not have a pool, but still great place to stay."
United States
Alice
The price is ₩121,666
₩139,915 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Candlewood Suites Odessa by IHG
Desk, laptop workspace, blackout drapes, iron/ironing board
Sleep Inn & Suites Odessa near University

Sleep Inn & Suites Odessa near University

Sleep Inn & Suites Odessa near University
2.5 star property
4.6 km from Odessa Regional Medical Center South Campus
8.6 out of 10, Excellent, (466)
"Very good"
United States
Sharmin
The price is ₩92,336
₩106,186 total
includes taxes & fees
Jan 16 - Jan 17, 2026
Sleep Inn & Suites Odessa near University
Lobby
Sonesta Essential Hotels Odessa

Sonesta Essential Hotels Odessa

Sonesta Essential Hotels Odessa
2.0 star property
3.7 km from Odessa Regional Medical Center South Campus
7.8 out of 10, Good, (752)
"Nice place"
United States
Jose
The price is ₩108,341
₩124,607 total
includes taxes & fees
Jan 15 - Jan 16, 2026
Sonesta Essential Hotels Odessa
Full-size fridge, microwave, stovetop, coffee/tea maker
Studio 6 Odessa, TX

Studio 6 Odessa, TX

Studio 6 Odessa, TX
2.5 star property
4 km from Odessa Regional Medical Center South Campus
8.0 out of 10, Very Good, (242)
"This property puts several others. I’ve stayed in Odessa to shame. This is a nice property. The rooms are clean and spacious that I’ve been in. There was a door that didn’t open particularly easy in room 102 but that didn’t really interfere with my trip at all. I would stay at this facility again."
United States
JIMMY
The price is ₩108,616
₩124,911 total
includes taxes & fees
Dec 27 - Dec 28
Studio 6 Odessa, TX
Lobby
TownePlace Suites by Marriott Odessa

TownePlace Suites by Marriott Odessa

TownePlace Suites by Marriott Odessa
3.0 star property
5.1 km from Odessa Regional Medical Center South Campus
9.0 out of 10, Wonderful, (513)
"Great service and breakfast was very good."
United States
Iris
The price is ₩139,047
₩159,904 total
includes taxes & fees
Dec 31 - Jan 1, 2026
TownePlace Suites by Marriott Odessa
Full-size fridge, microwave
Parkway Inn

Parkway Inn

Parkway Inn
2.0 star property
4.4 km from Odessa Regional Medical Center South Campus
8.4 out of 10, Very Good, (34)
"The cleanliness, tv and bed was awesome "
United States
Ellie
The price is ₩104,286
₩119,929 total
includes taxes & fees
Dec 27 - Dec 28
Parkway Inn
Exterior
Fairfield Inn & Suites Odessa

Fairfield Inn & Suites Odessa

Fairfield Inn & Suites Odessa
2.5 star property
4.9 km from Odessa Regional Medical Center South Campus
8.8 out of 10, Excellent, (411)
"We had a great stay! The staff was very friendly and helpful, especially Nizhoni at the front desk-she was amazing. The facility and rooms were clean, the beds were comfortable, and the complimentary breakfast had plenty of options. Would definitely stay here again. "
United States
Karinna
The price is ₩121,884
₩143,196 total
includes taxes & fees
Dec 31 - Jan 1, 2026
Fairfield Inn & Suites Odessa
View from room
MCM Elegante Hotel and Conference Center Odessa

MCM Elegante Hotel and Conference Center Odessa

MCM Elegante Hotel and Conference Center Odessa
3.5 star property
5.5 km from Odessa Regional Medical Center South Campus
9.0 out of 10, Wonderful, (1000)
"incredible stay at a 5 star hotel in Odessa Texas. Room was clean; Staff was excellent; Food was delicious. was pleasantly surprised. will stay out there again while visiting family & friends!"
United States
Patricia
The price is ₩144,928
₩166,654 total
includes taxes & fees
Dec 27 - Dec 28
MCM Elegante Hotel and Conference Center Odessa
Lobby
Comfort Inn & Suites, Odessa I-20

Comfort Inn & Suites, Odessa I-20

Comfort Inn & Suites, Odessa I-20
2.5 star property
4 km from Odessa Regional Medical Center South Campus
7.8 out of 10, Good, (570)
"Room was clean and comfortable "
United States
Dolores
The price is ₩109,572
₩126,008 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Comfort Inn & Suites, Odessa I-20
Outdoor pool
Hampton Inn by Hilton Odessa

Hampton Inn by Hilton Odessa

Hampton Inn by Hilton Odessa
2.5 star property
4.9 km from Odessa Regional Medical Center South Campus
8.6 out of 10, Excellent, (367)
"Always a great place to stay!!!"
United States
Xavier
The price is ₩129,488
₩150,388 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Hampton Inn by Hilton Odessa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Odessa Regional Medical Center South Campus Hotel Reviews

MCM Grande Hotel FunDome Odessa

MCM Grande Hotel FunDome Odessa

10/10 Excellent
"Everything seems great"
shawn 1-night trip
Posted 6 days ago
MCM Grande Hotel FunDome Odessa

Hotels near other Odessa Regional Medical Center South Campus attractions

White-Pool House

4.3/5 (20 reviews)
You can find out about the history of Odessa with a visit to White-Pool House. Experience the area's entertainment venues or attend a sporting event.
See properties

Parker House Museum

3.9/5 (53 reviews)
You can spend time browsing the exhibits at Parker House Museum in Odessa. While in this family-friendly area, you can savor the top-notch restaurants.
See properties

Frequently asked questions

What's the area like around Odessa Regional Medical Center South Campus?
Odessa Regional Medical Center South Campus is located in Odessa. This family-friendly area is known for its array of dining options. If you're looking for a convenient place to stay, check out the 9 hotels and other accommodations you'll find within a mile.
What's the best place to stay close to Odessa Regional Medical Center South Campus?
Odessa Marriott Hotel & Conference Center is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and an outdoor pool. It's located just a short 0.5 mi (0.7 km) from Odessa Regional Medical Center South Campus. Another good option is Motel 6 Odessa, TX - 2nd Street, located just 0.8 mi (1.3 km) away.
How many hotels will I be able to find close to Odessa Regional Medical Center South Campus?
Expedia has 9 hotels and other accommodations within a mile from Odessa Regional Medical Center South Campus.
If I need to cancel the hotel reservation for my stay near Odessa Regional Medical Center South Campus, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable if cancelled before the hotel's cancellation deadline, which often is within 24-48 hours of check in. If your reservation is non-refundable, it might still be possible to cancel it and get a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to review the best deals near Odessa Regional Medical Center South Campus.
Where can I learn more about changing or cancelling my trip in the area near Odessa Regional Medical Center South Campus?
To find more details about changing or cancelling your stay near Odessa Regional Medical Center South Campus, head over to our customer service page.
What can I see and do near Odessa Regional Medical Center South Campus?
White-Pool House, Ellen Noel Art Museum, and Parker House Museum feature a variety of fascinating exhibits to see while you're in town. Create some family memories at Altitude Trampoline Park and Fun City. Attractions like Globe of the Great Southwest and Presidential Museum and Leadership Library highlight the local culture.