Villa Murano is in a safe neighborhood, about 10 minutes walk down to Fira which is the city center. It is a bit of an uphill walk for half of it, so if you have mobility challenges, this might be hard for you. The front desk is very friendly but not 24 hours. They have a 24 hour phone number but my cell phone service was terrible in Santorini and I tried to call several times but couldn’t make a connection. They have a relationship with a driver which was nice, but we used the driver 3 times and he was late everytime: 10 minutes from picking us up at the airport, 20 minutes from Santo Winery, and 30 minutes from the hotel to the ferry port at 3am. I couldn’t call hime because I had bad cell phone service; wish I could’ve used a taxi so I didn’t have to worry that he would forget to pick us up. The room is small good sized and there’s a pool which is nice since beaches are hard to get to. The paint in the pool stuck to my skin and gave me an allergic reaction. Mary (front desk) was very friendly but there are so many hotels in the area, I’d recommend trying a different one.