Southern Indiana Vacations

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

    • payments icon

    Better together

    Save up to ₩234,741 when you book a flight and hotel together*
    lob hotels icon

    Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
    lob packages icon

    Rest easy

    Plan, book, and manage your trip all in one place

Where to stay in Southern Indiana

Find the best Southern Indiana areas and neighborhoods for the activities you enjoy most. Learn more about Southern Indiana
Louisville Science Center featuring outdoor art

West Main Historic District

Boasting the largest collection of cast iron façades outside New York's SoHo district, this historic area features "Museum Row" with attractions like the Louisville Slugger Museum and Muhammad Ali Center.

Find hotels in West Main Historic District

Find the Best Southern Indiana Vacation Packages

Southern Indiana Hotel Deals

Radisson Hotel Louisville North

Radisson Hotel Louisville North

3 out of 5
505 Marriott Drive, Clarksville, IN
Fully refundableReserve now, pay when you stay
The price is ₩78,427 per night from Aug 8 to Aug 9
₩78,427
₩88,624 total
Aug 8 - Aug 9
includes taxes & fees
6.8/10 (2,241 reviews)
"Great place for the price!"

Reviewed on Aug 4, 2025

Radisson Hotel Louisville North
Hyatt Place Evansville

Hyatt Place Evansville

3 out of 5
202 Se 2nd St, Evansville, IN
Fully refundableReserve now, pay when you stay
The price is ₩159,321 per night from Aug 16 to Aug 17
₩159,321
₩183,219 total
Aug 16 - Aug 17
includes taxes & fees
9.4/10 Exceptional! (1,006 reviews)
"The room was clean and comfortable. The staff were friendly and helpful. The parking was convenient. There' were a number of seating areas inside and out."

Reviewed on Aug 3, 2025

Hyatt Place Evansville
Quality Inn & Suites

Quality Inn & Suites

2.5 out of 5
440 South Main St, Ferdinand, IN
Fully refundableReserve now, pay when you stay
The price is ₩118,452 per night from Aug 18 to Aug 19
₩118,452
₩132,665 total
Aug 18 - Aug 19
includes taxes & fees
7/10 Good! (596 reviews)
"Nice property, stayed when we went to Holiday World. Staff was great and helpful."

Reviewed on Jul 29, 2025

Quality Inn & Suites
See all 1,443 properties in Southern Indiana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Southern Indiana

Holiday World and Splashin\' Safari featuring a waterpark as well as a small group of people

Holiday World and Splashin' Safari

5/5(100 reviews)

Every day is a holiday at this fun-filled combination theme park and water park, where visitors of all ages can explore roller coasters, raft rides and wave pools.

Holiday World and Splashin' Safari
Louisville Slugger Museum showing interior views

Louisville Slugger Museum

4.5/5(606 reviews)

Baseball is part of the American fabric. See where one important tool for this sport is produced in the factory that makes ball games possible.

Louisville Slugger Museum

Frequently asked questions

How much does a Southern Indiana vacation package cost?
We make it simple to travel somewhere new, with Southern Indiana vacation packages starting from just . You'll have the flexibility to combine your preferred airlines, hotels and car rental. For the ultimate escape, why not add a few activities and tours to your itinerary?
How do I get a cheap travel package to Southern Indiana?
If you love bargains, combine your bookings into a Southern Indiana vacation package. Whether you're looking for flights, hotels, day tours or rental cars, you can book everything in one place. You'll have plenty of choice at your fingertips too. Expedia has over 550 airlines and 1,000,000 hotels around the globe to take your pick of. Fly with who you want, stay where you like and save a packet — now that's the ideal getaway!
Where should I stay in Southern Indiana?
Louisville is a fantastic place to explore. It draws in many travelers who come to see its top sights, like Churchill Downs and Muhammad Ali Center.
What are the top hotels in Southern Indiana?
When it comes to properties in Louisville, Galt House Hotel Trademark Collection by Wyndham and Radisson Hotel Louisville Jeffersonville are two fantastic options. If you're also spending time in Jeffersonville - Clarksville, Radisson Hotel Louisville Jeffersonville and JW Marriott Indianapolis look forward to welcoming you.
How far in advance should I book my Southern Indiana vacation?
It all depends on the airline, but you can normally browse through international airfares on Expedia up to a year in advance. While it's a good idea to book ahead of time, lucky travelers will sometimes score a cheaper seat only weeks before the date of departure.
What does an Expedia Southern Indiana travel package include?
With Expedia, you can select any combination of flights, car rentals and hotels to create your ideal Southern Indiana travel package. Once you've made your booking, you can add on all the fun stuff like sightseeing tours and activities. Remember — the more you bundle, the greater the savings!
What should I know before booking a Southern Indiana travel package?
You'll save plenty with an Expedia travel package. Combine your airfares, rental cars and hotels and land fabulous discounts. Hotels aren't your only choice, though. Book with us and select from island resorts, rural cottages and everything in between!
Can I choose my airline with a Southern Indiana Expedia vacation package?
Expedia offers access to more than 550 partner airlines globally, so you certainly can. Simply select the carrier that suits you and create the perfect Southern Indiana trip.
If I'm not able to travel, can I cancel my Southern Indiana vacation package?
Yes, you can. We understand that even the best-laid plans can go awry, so we're here to help if you have to make changes to your Southern Indiana vacation package. You may be able to amend or cancel your itinerary at no cost if you've booked in the last 24 hours. Your hotel, airline or car rental company may impose a fee if your booking was made more than 24 hours ago. Have a look at our Customer Service Portal for more information. Also, be sure to check your itinerary for the finer details on change fees.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.