Find hotels in Southern Minnesota, MN from ₩107,948

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Compare 1,186 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Kahler Grand Hotel

3.0 star property
8.2 out of 10, Very Good, (1645)
"Great location, beautiful hotel!"
Kahler Grand Hotel

AmericInn by Wyndham Rochester Near Mayo Clinic

3.0 star property
8.2 out of 10, Very Good, (1059)
"Good place to stay "
AmericInn by Wyndham Rochester Near Mayo Clinic

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

3.0 star property
7.2 out of 10, Good, (1003)
"well kept great staff "
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

EVEN Hotel Rochester - Mayo Clinic Area by IHG

4.0 star property
9.4 out of 10, Exceptional, (914)
"Always stay here for my mayo visits "
EVEN Hotel Rochester - Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG

3.5 star property
8.8 out of 10, Excellent, (835)
"Very convenient to Mayo clinic and good restaurants. "
Hotel Indigo Rochester – Mayo Clinic Area by IHG

Aspen Suites

3.0 star property
9.0 out of 10, Wonderful, (660)
"Staff were very friendly, property was nice and clean."
Aspen Suites

AmericInn by Wyndham Lake City

2.5 star property
9.0 out of 10, Wonderful, (609)
"Nice area, friendly and efficient staff and the rooms were very nice and were clean."
AmericInn by Wyndham Lake City

Spark by Hilton Rochester South

3.0 star property
9.4 out of 10, Exceptional, (198)
"Check in was easy and staff was extremely helpful! We'll definitely stay here again. "
Spark by Hilton Rochester South

The Berkman

3.0 star property
9.6 out of 10, Exceptional, (349)
"Perfect place to stay, very clean and easy access. "
The Berkman

Microtel Inn & Suites by Wyndham Rochester North Mayo Clinic

2.0 star property
7.8 out of 10, Good, (1006)
"Was a nice hotel for the money. Breakfast was great. "
Microtel Inn & Suites by Wyndham Rochester North Mayo Clinic

AmericInn by Wyndham Winona

2.5 star property
9.0 out of 10, Wonderful, (851)
"We love the pet friendly aspect "
AmericInn by Wyndham Winona

Country Inn & Suites Rochester South Mayo Clinic

3.0 star property
8.4 out of 10, Very Good, (1002)
"A good place to stay."
Country Inn & Suites Rochester South Mayo Clinic

St James Hotel, a Historic Hotel of America

3.5 star property
9.2 out of 10, Wonderful, (1001)
"Love the historical hotel. Very clean and the staff was great. "
St James Hotel, a Historic Hotel of America

Days Inn by Wyndham Winona

2.0 star property
7.8 out of 10, Good, (1003)
"The room was very nice, bed was very comfortable, and the staff friendly."
Days Inn by Wyndham Winona

Brentwood Inn & Suites

2.5 star property
8.8 out of 10, Excellent, (1001)
"This hotel is very convenient and affordable for appointments at Mayo. "
Brentwood Inn & Suites

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

3.0 star property
8.6 out of 10, Excellent, (1003)
"We stay here every year for the dog show. It's pet friendly and in a great location "
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

2.5 star property
8.2 out of 10, Very Good, (740)
"staff was great no complaints room was phenomenal."
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Residence Inn by Marriott Rochester Mayo Clinic Area South

3.0 star property
9.6 out of 10, Exceptional, (225)
"Great place"
Residence Inn by Marriott Rochester Mayo Clinic Area South

Med City Inn & Suites - Mayo Clinic Area

2.5 star property
7.8 out of 10, Good, (1001)
"Good location "
Med City Inn & Suites - Mayo Clinic Area

Aspen Select

3.5 star property
8.4 out of 10, Very Good, (1003)
"Clean room | Staff was helpful and friendly"
Aspen Select
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Discover the family-friendly area of Southern Minnesota—an opera house, a college vibe, and sights from Mount Kato Ski Area to Blakeslee Stadium.

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