Best Western Hotels: Book Best Western Hotel Rooms & Suites in Upstate South Carolina, South Carolina

A bench, a bicycle, and a lake surrounded by trees.

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Our top choices for Upstate South Carolina Best Western

A modern lobby with a reception desk, seating area, and a television screen.

A hotel with a covered entrance, brick exterior, and a sign indicating it is a Best Western hotel.

A modern restaurant with high tables and chairs, a counter with a coffee machine, and a patterned wall.

A swimming pool with lounge chairs and tables, surrounded by brick buildings and a covered seating area.

1. Best Western Spartanburg I-26

Spartanburg

Santhosh

₩123,618

₩137,215 total

includes taxes & fees

Nov 1 - Nov 2

A modern living room with a fireplace, two sofas, and a coffee table.

A modern gym with various exercise equipment, motivational wall graphics, and a large window offering a view of the outdoors.

A hotel room with two beds, a desk, a TV, and a window with curtains.

A reception area with two wooden reception desks, a blue accent wall, and a mounted television.

2. Best Western Spartanburg Northwest

Spartanburg

Herbert

₩123,618

₩139,959 total

includes taxes & fees

Nov 8 - Nov 9

A fire pit with a bench on a concrete patio, surrounded by trees and a view of a body of water.

A reception area with a stone wall, wooden reception desk, and a potted plant.

A Best Western hotel with a modern design, multiple flags, and well-lit signage.

A hotel room with two beds, a desk, a chair, a desk lamp, a bathroom with a mirror, and a window with curtains.

3. Best Western Travelers Rest Greenville

Travelers Rest

Susan

₩129,142

₩142,055 total

includes taxes & fees

Oct 25 - Oct 26

A hotel room with a bed, a desk, a chair, a large window with curtains, a bathroom with a bathtub, and a flat-screen TV.

A multi-story hotel with a prominent entrance, parking area, and a car parked in front.

A reception area with a brick wall, a reception desk, and a glass door leading outside.

A breakfast bar with waffle makers, coffee machines, and a clock on the wall.

4. Best Western Seneca-Clemson

Seneca

Michelle

₩124,766

₩137,243 total

includes taxes & fees

Oct 21 - Oct 22

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Top Upstate South Carolina Hotel Reviews

Hotel Hartness

10/10 Excellent

"There is not one negative thing I could mention. We thoroughly enjoyed our visit and loved the accommodations immensely."

Hilton Greenville

8/10 Good

"I enjoy my vacation at the Hilton. Although the rooms were clean but dated. And I appreciated the security of having the room key to access the elevator it saw so what annoying when your hands were full to get the elevator to go to the floor you were on. Staff was friendly. and I didn’t check out any of the amenities, but I do know they were available."