A bench, a bicycle, and a lake surrounded by trees.

Find Resorts & Hotels with Spas in Upstate South Carolina, SC

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Upstate South Carolina Resorts & Hotels with Spas

Tonight
Sep 22 - Sep 23
Tomorrow
Sep 23 - Sep 24
This weekend
Sep 25 - Sep 27
Next weekend
Oct 2 - Oct 4

Our top choices for Upstate South Carolina hotels with a spa

A modern hotel lobby with a chandelier, wooden shelving, a reception desk, and a view of the outdoors.
A restaurant with a bar area, green upholstered seating, and a view of trees through large windows.
A large, two-story house with a symmetrical facade, large windows, and a central entrance.
A cozy lounge area with leather armchairs, a central table, and a fireplace.

1. Hotel Hartness

Hotel Hartness
Greenville
  • Indulge in rejuvenating treatments at this upscale hotel with six couples spa rooms and scenic hiking trails for a peaceful escape.
₩209,061
₩282,201 total
includes taxes & fees
Oct 4 - Oct 5
Hotel Hartness
A spa room with two beds, a mural, and a reception desk.
A large, multi-story house with a prominent waterfall in the foreground, surrounded by lush greenery.
A modern interior with a stone fireplace, leather sofas, and a wooden ceiling.
A modern interior with a fireplace, plush seating, and a stone accent wall.

2. Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection
Greenville Downtown
  • Escape to a Tudor retreat with a full-service spa and rooftop garden overlooking the scenic river in Greenville.
₩527,212
₩597,322 total
includes taxes & fees
Sep 27 - Sep 28
Grand Bohemian Lodge Greenville, Autograph Collection
A two-story house with a tiled roof, a stone fire pit, and outdoor seating.
A bar with a large window view of mountains and a chandelier.
A spacious room with wooden beams, a large chandelier, and a cozy seating area with orange chairs and a white sofa.
A reception area with a wooden reception desk, a large abstract painting, and a potted plant.

3. Hotel Domestique

Hotel Domestique
Travelers Rest
  • Retreat to this mountain hotel with therapeutic massage treatments, sauna, and seasonal outdoor pool for deep relaxation.
₩575,601
₩633,161 total
includes taxes & fees
Sep 24 - Sep 25
Hotel Domestique

4. Bed & Breakfast on Tiffany Hill

Bed & Breakfast on Tiffany Hill
Mills River
₩370,913
₩418,204 total
includes taxes & fees
Sep 27 - Sep 28
Bed & Breakfast on Tiffany Hill
A large, two-story building with a stone facade and a spacious lawn with lounge chairs.
A bedroom with a stone fireplace, a ceiling fan, a large window with a view, and two red upholstered chairs.
A covered porch with wicker furniture, a ceiling fan, and potted plants.
A cozy living room with a fireplace, comfortable seating, and a dining area.

5. Echo Mountain Inn

Echo Mountain Inn
Hendersonville
  • Experience mountain tranquility at this charming bed and breakfast, where spa services and garden views create a serene wellness retreat.
₩208,852
₩235,482 total
includes taxes & fees
Sep 29 - Sep 30
Echo Mountain Inn
A hotel room with two beds, a desk, a chair, a mirror, and a window with curtains.
A modern bathroom with a glass shower enclosure, a white toilet, and a sink with a mirror above it.
A bedroom with a bed, a ceiling fan, a bedside table, and a nightstand.
A covered porch with a view of a street, two potted plants, and an American flag.

6. 1898 Waverly Inn

1898 Waverly Inn
Hendersonville
  • Experience spa bliss at this charming B&B with relaxing massage treatment rooms and attentive staff who ensure a rejuvenating stay.
₩204,689
₩230,788 total
includes taxes & fees
Sep 28 - Sep 29
1898 Waverly Inn
A reception desk with a logo, a Buddha statue, a vase, and a door labeled 'EMPLOYEES ONLY'.
A modern kitchen with white cabinets, a stainless steel sink, and a wooden staircase leading to a balcony.
A bedroom with a large bed, a nightstand, a desk, a chair, a sofa, a window, and a door.
A bedroom with a bed, a nightstand, a lamp, and a view of a balcony with outdoor furniture.

7. SKYLARANNA Resort & Spa

SKYLARANNA Resort & Spa
Hendersonville
  • Rejuvenate in a mountain spa retreat with 3 dedicated treatment rooms, hot tubs, and aromatherapy services along a scenic river.
₩165,056
₩232,570 total
includes taxes & fees
Sep 24 - Sep 25
SKYLARANNA Resort & Spa
A round table set for four with wicker chairs, a white tablecloth, and a view of a forested area through large windows.
A bedroom with two beds, wooden headboard panels, and a window with a view.
A wooden bridge over a small water feature with a large water wheel in the background.
A bathroom with a shower area, a toilet, and a sink.

8. Sylvan Falls Mill B&B

Sylvan Falls Mill B&B
Rabun Gap
  • Serene mountain retreat offers restorative massages in a garden setting, steps away from Chattahoochee National Forest.
₩254,144
₩301,676 total
includes taxes & fees
Sep 27 - Sep 28
Sylvan Falls Mill B&B
A spacious living area with a leather sofa, wooden chairs, and a dining table.
A bar area with a long counter, multiple stools, and a stone wall.
An aerial view of a residential area with houses, a golf course, and a lake.
A spacious lobby with a central coffee table, seating area, and a reception desk.

9. Kingwood Resort

Kingwood Resort
Clayton
  • Mountain escape with a full-service spa and golf course offers soothing body treatments and steam room amenities.
₩162,221
₩211,218 total
includes taxes & fees
Oct 7 - Oct 8
Kingwood Resort
A two-story wooden cabin with a balcony, a swimming pool, and a deck area.
A two-story wooden house with a porch, surrounded by dense forest.
A wooden interior with tables and chairs, a fireplace, and a stone wall.
A cozy room with a bed, a chair, a tray with snacks and wine, and a view of the outdoors.

10. Glen-Ella Springs Hotel & Restaurant

Glen-Ella Springs Hotel & Restaurant
Clarkesville
  • Relaxing country retreat with in-room massages and a serene garden setting for a rejuvenating spa experience.
₩313,902
₩358,453 total
includes taxes & fees
Sep 27 - Sep 28
Glen-Ella Springs Hotel & Restaurant
View all properties

Choose what matters most at spa hotels in Upstate South Carolina

Pool
Breakfast included
Hot tub
4 stars
5 stars

Top Upstate South Carolina Hotel Reviews

Explore a world of travel with Expedia